Phlpp1 ELISA Kit for Mouse(Mus musculus) | EIAab.comPhlpp1 ELISA Kit for Mouse(Mus musculus)

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Phlpp1 (Gene name),

PH domain leucine-rich repeat-containing protein phosphatase 1 (Protein name ), PHLP1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Phlpp1(Kiaa0606;Phlpp;Plekhe1;Scop);

Protein name:

PH domain leucine-rich repeat-containing protein phosphatase 1;

Alternative:

Suprachiasmatic nucleus circadian oscillatory protein;Pleckstrin homology domain-containing family E member 1(PH domain-containing family E member 1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with the nucleotide free form of K-Ras (KRAS) via its LRR repeats. Interacts with AKT2, AKT3 and PRKCB.

Function:

Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB, and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. May act as a negative regulator of K-Ras signaling in membrane rafts.

Subcellular Location:

Cytoplasm Membrane Peripheral membrane protein Nucleus

Protein Attributes:

Sequence length:

1687

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1687:

PPPQPPQPQP | QPQPQPQPQP | QRHFQMDHLP | DCYDTPL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q8CHE4

KEGG:

mmu:98432

String:

Q8CHE4

Pfam:

PF00560

UniGene:

Mm.24115

Uniprot:

Q8CHE4

FOR

ELISA Kit for Mouse PH domain leucine-rich repeat-containing protein phosphatase 1

CLIA Kit for Mouse PH domain leucine-rich repeat-containing protein phosphatase 1

Polyclonal Antibody for Mouse PH domain leucine-rich repeat-containing protein phosphatase 1

Monoclonal Antibody for Mouse PH domain leucine-rich repeat-containing protein phosphatase 1

Protein for Mouse PH domain leucine-rich repeat-containing protein phosphatase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
2.

"Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Hara Y. , Nagase T. , Ohara O. , Koga H.
DNA Res.9:179-188(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 370-1687
tissue: Brain.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 424-1687
strain: C57BL/6.
strain: Czech II.
strain: FVB/N.
tissue: Brain.
tissue: Mammary tumor.
4.

"Changes in expression of the mouse homologues of KIAA genes after subchronic methamphetamine treatment."
Yamamoto H. , Imai K. , Takamatsu Y. , Kamegaya E. , Hara Y. , Shimada K. , Yamamoto T. , Shen H.W. , Hagino Y. , Kobayashi H. , Ide S. , Sora I. , Koga H. , Ikedaa K.
Ann. N. Y. Acad. Sci.1025:92-101(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION

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