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Index > Protein center > Pja2(Gene name) > Mouse
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  • Pja2 (Gene name),
  • E3 ubiquitin-protein ligase Praja-2 (Protein name ),  PJA2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Pja2(Kiaa0438;Rnf131);
    Protein name:
    E3 ubiquitin-protein ligase Praja-2(Praja2);
    Alternative:
    RING finger protein 131;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Binds ubiquitin-conjugating enzymes (E2s). In vitro, interacts with the ubiquitin-conjugating enzyme, UBE2D2. The phosphorylated form interacts with PRKAR1A, PRKAR2A and PRKAR2B. Binds the catalytic subunits of cAMP-dependent protein kinase.
    Function:
    Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes.
    Subcellular Location:
    Cytoplasm Cell membrane Endoplasmic reticulum membrane Peripheral membrane protein Golgi apparatus membrane Peripheral membrane protein Cell junction synapse Cell junction synapse postsynaptic cell membrane postsynaptic density Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus. Expressed in the postsynaptic density region of synapses. Co-localizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane.
    Protein Attributes:
    Sequence length:
    707
    Sequence:
    50:
    MSQYTEKEPS | VMDQESSKAA | WPKPAGGYQT | ITGRRYGRRH | AYVSFKPCMT | 
    100:
    RHERSLGRAG | DDYEVLELDD | VPKENTSGSS | SLDQVHPALP | NEPTVEKSET | 
    150:
    EISTCGPALN | QSTESSPSIA | TVCHSEEVRE | TLESNTNLHN | RTETEHTPAV | 
    200:
    CNVSSVQNGI | MLVHTDSYDP | DSKHDENGSL | QLGAEAVEGG | RHQKGLGRAV | 
    250:
    FELENGEAEI | YADLSPSVPS | LNGEISEAFE | ELDSAPLEKS | STADAELVHQ | 
    300:
    NGQEFQRSSE | DGVVRKRRQD | DTDQGRQTEN | STEDADCAPG | HVEQNTSDRA | 
    350:
    NHHGSSPEQV | VRPKVRKVIS | SSQVDQEIGF | NRHEAKQRSV | QRWREALEVE | 
    400:
    ECSSDDPIIK | CDDYDGDHDC | MFLTPTYSRV | TQRETERNRV | TSENGATASG | 
    450:
    RQESRDNAFW | NACGEYYQLF | DKDEDSSECS | DGEWSASLPH | RFSGTEKDQS | 
    500:
    SSDDSWETLP | GKDENDPELQ | SDSSGPEEEN | QELSLQEGEQ | TSLEEGEIPW | 
    550:
    LQYNEVNESS | SDEGNEPANE | FAQPEAFMLD | GNNNLEDDSS | VSEDLDVDWS | 
    600:
    LFDGFADGLG | VAEAISYVDP | QFLTYMALEE | RLAQAMETAL | AHLESLAVDV | 
    650:
    EVANPPASKE | SIDGLPETLV | LEDHTAIGQE | QCCPICCSEY | IKDDIATELP | 
    700:
    CHHFFHKPCV | SIWLQKSGTC | PVCRRHFPPA | VIDASAAASS | DPDPDASPAN | 
    707:
    DNAEEAP
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Praja2
    ELISA Kit for Mouse Praja2
    ELISA Kit for Mouse Praja2
    CLIA Kit for Mouse Praja2
    CLIA Kit for Mouse Praja2
    CLIA Kit for Mouse Praja2
    Polyclonal Antibody for Mouse Praja2
    Polyclonal Antibody for Mouse Praja2
    Polyclonal Antibody for Mouse Praja2
    Monoclonal Antibody for Mouse Praja2
    Monoclonal Antibody for Mouse Praja2
    Monoclonal Antibody for Mouse Praja2
    Protein for Mouse Praja2
    Protein for Mouse Praja2
    Protein for Mouse Praja2

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    Precision
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    Linearity
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    References
    1. 1.
      "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain."
      Yu P. , Chen Y. , Tagle D.A. , Cai T.
      Genomics79:869-874(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
      strain: 129/SvJ.
    2. 2.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Aizawa H. , Yuasa S. , Nakajima D. , Nagase T. , Ohara O. , Koga H.
      DNA Res.10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      tissue: Heart.
      tissue: Lung.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 326-707 (ISOFORM 1)
      strain: FVB/N.
      tissue: Eye.
      tissue: Mammary tumor.
    5. 5.
      Lubec G. , Sunyer B. , Chen W.-Q.
      Submitted (2009-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 8-18;IDENTIFICATION BY MASS SPECTROMETRY
      strain: OF1.
      tissue: Hippocampus.
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