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Index > Protein center > PSPC1(Gene name) > Human
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  • PSPC1 (Gene name),
  • Paraspeckle component 1 (Protein name ),  PSPC1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PSPC1(PSP1);
    Protein name:
    Paraspeckle component 1;
    Alternative:
    Paraspeckle protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms heterodimers with NONO. Found in a RNP complex with CAT2 transcribed nuclear RNA (CTN-RNA). Interaction with NONO is required for its targeting to paraspeckles and perinucleolar caps. Interacts with SFPQ.
    Function:
    Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers.
    Subcellular Location:
    Nucleus nucleolus Nucleus matrix Cytoplasm In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in a RNA-dependent manner. May cycles between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps.
    Protein Attributes:
    Sequence length:
    523
    Sequence:
    50:
    MMLRGNLKQV | RIEKNPARLR | ALESAVGESE | PAAAAAMALA | LAGEPAPPAP | 
    100:
    APPEDHPDEE | MGFTIDIKSF | LKPGEKTYTQ | RCRLFVGNLP | TDITEEDFKR | 
    150:
    LFERYGEPSE | VFINRDRGFG | FIRLESRTLA | EIAKAELDGT | ILKSRPLRIR | 
    200:
    FATHGAALTV | KNLSPVVSNE | LLEQAFSQFG | PVEKAVVVVD | DRGRATGKGF | 
    250:
    VEFAAKPPAR | KALERCGDGA | FLLTTTPRPV | IVEPMEQFDD | EDGLPEKLMQ | 
    300:
    KTQQYHKERE | QPPRFAQPGT | FEFEYASRWK | ALDEMEKQQR | EQVDRNIREA | 
    350:
    KEKLEAEMEA | ARHEHQLMLM | RQDLMRRQEE | LRRLEELRNQ | ELQKRKQIQL | 
    400:
    RHEEEHRRRE | EEMIRHREQE | ELRRQQEGFK | PNYMENREQE | MRMGDMGPRG | 
    450:
    AINMGDAFSP | APAGNQGPPP | MMGMNMNNRA | TIPGPPMGPG | PAMGPEGAAN | 
    500:
    MGTPMMPDNG | AVHNDRFPQG | PPSQMGSPMG | SRTGSETPQA | PMSGVGPVSG | 
    523:
    GPGGFGRGSQ | GGNFEGPNKR | RRY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    String:
    MIM:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Paraspeckle component 1
    ELISA Kit for Human Paraspeckle component 1
    ELISA Kit for Human Paraspeckle component 1
    ELISA Kit for Human Paraspeckle component 1
    ELISA Kit for Human Paraspeckle component 1
    CLIA Kit for Human Paraspeckle component 1
    CLIA Kit for Human Paraspeckle component 1
    CLIA Kit for Human Paraspeckle component 1
    CLIA Kit for Human Paraspeckle component 1
    CLIA Kit for Human Paraspeckle component 1
    Polyclonal Antibody for Human Paraspeckle component 1
    Polyclonal Antibody for Human Paraspeckle component 1
    Polyclonal Antibody for Human Paraspeckle component 1
    Polyclonal Antibody for Human Paraspeckle component 1
    Polyclonal Antibody for Human Paraspeckle component 1
    Monoclonal Antibody for Human Paraspeckle component 1
    Monoclonal Antibody for Human Paraspeckle component 1
    Monoclonal Antibody for Human Paraspeckle component 1
    Monoclonal Antibody for Human Paraspeckle component 1
    Monoclonal Antibody for Human Paraspeckle component 1
    Protein for Human Paraspeckle component 1
    Protein for Human Paraspeckle component 1
    Protein for Human Paraspeckle component 1
    Protein for Human Paraspeckle component 1
    Protein for Human Paraspeckle component 1

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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);PROTEIN SEQUENCE OF 21-83; 105-124; 135-143; 185-194; 199-210; 252-259; 265-289; 327-345; 352-357; 366-374 AND 483-507;IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Placenta.
    3. 3.
      "The DNA sequence and analysis of human chromosome 13."
      Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
      Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Skin.
    6. 6.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-523 (ISOFORM 2)
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 192-523 (ISOFORM 2)
      tissue: Kidney.
    8. 8.
      "P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner."
      Fox A.H. , Bond C.S. , Lamond A.I.
      Mol. Biol. Cell16:5304-5315(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;INTERACTION WITH NONO;MUTAGENESIS OF PHE-119; PHE-121; LYS-198 AND PHE-200;SUBCELLULAR LOCATION
    9. 9.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    10. 10.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409; SER-473 AND SER-477;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation."
      Passon D.M. , Lee M. , Rackham O. , Stanley W.A. , Sadowska A. , Filipovska A. , Fox A.H. , Bond C.S.
      Proc. Natl. Acad. Sci. U.S.A.109:4846-4850(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 61-320 IN COMPLEX WITH NONO;FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF TYR-275 AND TRP-279
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