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Index > Protein center > Ptbp2(Gene name) > Mouse
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  • Ptbp2 (Gene name),
  • Polypyrimidine tract-binding protein 2 (Protein name ),  PTBP2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Ptbp2(Brptb;Nptb);
    Protein name:
    Polypyrimidine tract-binding protein 2;
    Alternative:
    Neural polypyrimidine tract-binding protein;Brain-enriched polypyrimidine tract-binding protein(Brain-enriched PTB);RRM-type RNA-binding protein brPTB;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Part of a ternary complex containing KHSRP and HNRPH1 (By similarity). Interacts with NOVA1; the interaction is direct. Interacts with NOVA2; the interaction is direct.
    Function:
    RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre-mRNA splicing, plays also a role in the regulation of translation.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    531
    Sequence:
    50:
    MDGIVTEVAV | GVKRGSDELL | SGSVLSSPNS | NMSGMVVTAN | GNDSKKFKGE | 
    100:
    DKMDGAPSRV | LHIRKLPGEV | TETEVIALGL | PFGKVTNILM | LKGKNQAFLE | 
    150:
    LATEEAAITM | VNYYSAVTPH | LRNQPIYIQY | SNHKELKTDN | TLNQRAQVVL | 
    200:
    QAVTAVQTAN | TPLSGTTVSE | SAVTPAQSPV | LRIIIDNMYY | PVTLDVLHQI | 
    250:
    FSKFGAVLKI | ITFTKNNQFQ | ALLQYGDPVN | AQQAKLALDG | QNIYNACCTL | 
    300:
    RIDFSKLVNL | NVKYNNDKSR | DYTRPDLPSG | DGQPALDPAI | AAAFAKETSL | 
    350:
    LAVPGALSPL | AIPNAAAAAA | AAAAGRVGMP | GVSAGGNTVL | LVSNLNEEMV | 
    400:
    TPQSLFTLFG | VYGDVQRVKI | LYNKKDSALI | QMADGNQSQL | AMNHLNGQKM | 
    450:
    YGKIIRVTLS | KHQTVQLPRE | GLDDQGLTKD | FGNSPLHRFK | KPGSKNFQNI | 
    500:
    FPPSATLHLS | NIPPSVAEED | LRTLFANTGG | TVKAFKFFQD | HKMALLQMAT | 
    531:
    VEEAIQALID | LHNYNLGENH | HLRVSFSKST | I
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Polypyrimidine tract-binding protein 2
    ELISA Kit for Mouse Polypyrimidine tract-binding protein 2
    ELISA Kit for Mouse Polypyrimidine tract-binding protein 2
    CLIA Kit for Mouse Polypyrimidine tract-binding protein 2
    CLIA Kit for Mouse Polypyrimidine tract-binding protein 2
    CLIA Kit for Mouse Polypyrimidine tract-binding protein 2
    Polyclonal Antibody for Mouse Polypyrimidine tract-binding protein 2
    Polyclonal Antibody for Mouse Polypyrimidine tract-binding protein 2
    Polyclonal Antibody for Mouse Polypyrimidine tract-binding protein 2
    Monoclonal Antibody for Mouse Polypyrimidine tract-binding protein 2
    Monoclonal Antibody for Mouse Polypyrimidine tract-binding protein 2
    Monoclonal Antibody for Mouse Polypyrimidine tract-binding protein 2
    Protein for Mouse Polypyrimidine tract-binding protein 2
    Protein for Mouse Polypyrimidine tract-binding protein 2
    Protein for Mouse Polypyrimidine tract-binding protein 2

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    Precision
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    Linearity
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    References
    1. 1.
      "A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing."
      Polydorides A.D. , Okano H.J. , Yang Y.Y.L. , Stefani G. , Darnell R.B.
      Proc. Natl. Acad. Sci. U.S.A.97:6350-6355(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INTERACTION WITH NOVA1 AND NOVA2;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;SUBCELLULAR LOCATION
      tissue: Brain.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 421-531 (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Cerebellum.
      tissue: Hippocampus.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: FVB/N.
      tissue: Mammary tumor.
    4. 4.
      "Evolutionary conservation of a 2-kb intronic sequence flanking a tissue-specific alternative exon in the PTBP2 gene."
      Rahman L. , Bliskovski V. , Kaye F.J. , Zajac-Kaye M.
      Genomics83:76-84(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 344-361
    5. 5.
      "Cell-specific proteins regulate viral RNA translation and virus-induced disease."
      Pilipenko E.V. , Viktorova E.G. , Guest S.T. , Agol V.I. , Roos R.P.
      EMBO J.20:6899-6908(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "Comparative expression analysis of the genes encoding polypyrimidine tract binding protein (PTB) and its neural homologue (brPTB) in prenatal and postnatal mouse brain."
      Lillevaeli K. , Kulla A. , Oerd T.
      Mech. Dev.101:217-220(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    7. 7.
      "Alternative splicing of brain-specific PTB defines a tissue-specific isoform pattern that predicts distinct functional roles."
      Rahman L. , Bliskovski V. , Reinhold W. , Zajac-Kaye M.
      Genomics80:245-249(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 2)
    8. 8.
      "Phosphoproteomic analysis of the developing mouse brain."
      Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
      Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-308;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic brain.
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