Cd8a Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comCd8a Polyclonal Antibody for Mouse(Mus musculus)

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Cd8a (Gene name),

T-cell surface glycoprotein CD8 alpha chain (Protein name ), CD8A_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cd8a(Lyt-2;Lyt2);

Protein name:

T-cell surface glycoprotein CD8 alpha chain;

Alternative:

T-cell surface glycoprotein Lyt-2;

CD:

CD8a;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers.

Function:

Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

247

Sequence:

50:

100:

150:

200:

247:

LAGICVALLL | SLIITLICYH | RSRKRVCKCP | RPLVRQEGKP | RPSEKIV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.1858

KEGG:

mmu:12525

Pfam:

PF00047

String:

P01731

SMR:

P01731

Uniprot:

P01731

FOR

ELISA Kit for Mouse T-cell surface glycoprotein CD8 alpha chain

Cat.:

E0953h

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96T

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ELISA Kit for Mouse T-cell surface glycoprotein CD8 alpha chain

Cat.:

E0953r

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96T

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ELISA Kit for Mouse T-cell surface glycoprotein CD8 alpha chain

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E0953d

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ELISA Kit for Mouse T-cell surface glycoprotein CD8 alpha chain

Cat.:

E0953b

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96T

ELISA Kit for Mouse T-cell surface glycoprotein CD8 alpha chain

Cat.:

E0953m

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96T

CLIA Kit for Mouse T-cell surface glycoprotein CD8 alpha chain

Cat.:

U0953m

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96T

CLIA Kit for Mouse T-cell surface glycoprotein CD8 alpha chain

Cat.:

U0953r

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Manual:

Looking for manual.

MSDS:

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96T

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CLIA Kit for Mouse T-cell surface glycoprotein CD8 alpha chain

Cat.:

U0953h

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Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse T-cell surface glycoprotein CD8 alpha chain

Cat.:

U0953b

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MSDS:

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Packing:

96T

CLIA Kit for Mouse T-cell surface glycoprotein CD8 alpha chain

Cat.:

U0953d

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96T

Polyclonal Antibody for Mouse T-cell surface glycoprotein CD8 alpha chain

Cat.:

P0953Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse T-cell surface glycoprotein CD8 alpha chain

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P0953Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse T-cell surface glycoprotein CD8 alpha chain

Cat.:

P0953Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse T-cell surface glycoprotein CD8 alpha chain

Protein for Mouse T-cell surface glycoprotein CD8 alpha chain

R&D Technical Data

Western blot-Anti-CD8A antibody

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤ 4.5%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤ 9.5%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	97	93-103
Plasma	98	91-105

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	90-104%	92-99%	95-102%	89-103%
EDTA plasma(n=5)	88-96%	90-101%	87-103%	93-107%
heparin plasma(n=5)	94-102%	95-105%	98-109%	92-105%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to its human counterpart, Leu-2/T8, and to immunoglobulin variable regions."
Nakauchi H. , Nolan G.P. , Hsu C. , Huang H.S. , Kavathas P. , Herzenberg L.A.
Proc. Natl. Acad. Sci. U.S.A.82:5126-5130(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BALB/c.
2.

"Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA."
Zamoyska R. , Vollmer A.C. , Sizer K.C. , Liaw C.W. , Parnes J.R.
Cell43:153-163(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Isolation and characterization of the gene for the murine T cell differentiation antigen and immunoglobulin-related molecule, Lyt-2."
Nakauchi H. , Tagawa M. , Nolan G.P. , Herzenberg L.A.
Nucleic Acids Res.15:4337-4347(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Nucleotide sequence analysis of the C.AKR Lyt-2a gene: structural polymorphism in alleles encoding the Lyt-2.1 T-cell surface alloantigen."
Youn H.J. , Harriss J.V. , Gottlieb P.D.
Immunogenetics28:345-352(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: C.AKR.
5.

"Structure, sequence, and polymorphism of the Lyt-2 T cell differentiation antigen gene."
Liaw C.W. , Zamoyska R. , Parnes J.R.
J. Immunol.137:1037-1043(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

"Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb."
Kern P.S. , Teng M.K. , Smolyar A. , Liu J.H. , Liu J. , Hussey R.E. , Spoerl R. , Chang H.-C. , Reinherz E.L. , Wang J.-H.
Immunity9:519-530(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 28-152 IN COMPLEX WITH H-2KB
7.

"The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I."
Shore D.A. , Issafras H. , Landais E. , Teyton L. , Wilson I.A.
J. Mol. Biol.384:1190-1202(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 28-151 IN COMPLEX WITH CD8B AND ANTIBODY;SUBUNIT;DISULFIDE BOND;GLYCOSYLATION AT ASN-69

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