Protein name:
Complement C3 ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
C3dg interacts with CR2 (via the N-terminal Sushi domains 1 and 2). Interacts with VSIG4 (By similarity). C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain).
Function:
Complement C3 alpha chain and neutrophil chemotactic factor-2 act as chemoattractants for neurophils.
Subcellular Location:
Secreted
Protein Attributes:
50:
MGPTSGSQLL | VLLLLLASSL | LALGSPMYSI | ITPNVLRLES | EETFILEAHD |
100:
AQGDVPVTVT | VQDFLKKQVL | TSEKTVLTGA | TGHLNRVFIK | IPASKEFNAD |
150:
KGHKYVTVVA | NFGATVVEKA | VLVSFQSGYL | FIQTDKTIYT | PGSTVFYRIF |
200:
TVDNNLLPVG | KTVVIVIETP | DGVPIKRDIL | SSHNQYGILP | LSWNIPELVN |
250:
MGQWKIRAFY | EHAPKQTFSA | EFEVKEYVLP | SFEVLVEPTE | KFYYIHGPKG |
300:
LEVSITARFL | YGKNVDGTAF | VIFGVQDEDK | KISLALSLTR | VLIEDGSGEA |
350:
VLSRKVLMDG | VRPSSPEALV | GKSLYVSVTV | ILHSGSDMVE | AERSGIPIVT |
400:
SPYQIHFTKT | PKFFKPAMPF | DLMVFVTNPD | GSPARRVPVV | TQGSDAQALT |
450:
QDDGVAKLSV | NTPNNRQPLT | ITVSTKKEGI | PDARQATRTM | QAQPYSTMHN |
500:
SNNYLHLSVS | RVELKPGDNL | NVNFHLRTDA | GQEAKIRYYT | YLVMNKGKLL |
550:
KAGRQVREPG | QDLVVLSLPI | TPEFIPSFRL | VAYYTLIGAN | GQREVVADSV |
600:
WVDVKDSCVG | TLVVKGDPRD | NRQPAPGHQT | TLRIEGNQGA | RVGLVAVDKG |
650:
VFVLNKKNKL | TQSKIWDVVE | KADIGCTPGS | GKNYAGVFMD | AGLTFKTNQG |
700:
LQTDQREDPE | CAKPAARRRR | SVQLMERRMD | KAGQYTDKGL | RKCCEDGMRD |
750:
IPMPYSCQRR | ARLITQGESC | LKAFMDCCNY | ITKLREQHRR | DHVLGLARSD |
800:
VDEDIIPEED | IISRSHFPES | WLWTIEELKE | PEKNGISTKV | MNIFLKDSIT |
850:
TWEILAVSLS | DKKGICVADP | YEITVMQDFF | IDLRLPYSVV | RNEQVEIRAV |
900:
LFNYREQEKL | KVRVELLHNP | AFCSMATAKK | RYYQTIEIPP | KSSVAVPYVI |
950:
VPLKIGLQEV | EVKAAVFNHF | ISDGVKKILK | VVPEGMRVNK | TVAVRTLDPE |
1000:
HLNQGGVQRE | DVNAADLSDQ | VPDTDSETRI | LLQGTPVAQM | AEDAVDGERL |
1050:
KHLIVTPSGC | GEQNMIGMTP | TVIAVHYLDQ | TEQWEKFGLE | KRQEALELIK |
1100:
KGYTQQLAFK | QPISAYAAFN | NRPPSTWLTA | MWSRSFSLAA | NLIAIDSQVL |
1150:
CGAVKWLILE | KQKPDGVFQE | DGPVIHQEMI | GGFRNTKEAD | VSLTAFVLIA |
1200:
LQEARDICEG | QVNSLPGSIN | KAGEYLEASY | LNLQRPYTVA | IAGYALALMN |
1250:
KLEEPYLTKF | LNTAKDRNRW | EEPGQQLYNV | EATSYALLAL | LLLKDFDSVP |
1300:
PVVRWLNDER | YYGGGYGSTQ | ATFMVFQALA | QYRADVPDHK | DLNMDVSLHL |
1350:
PSRSSPTVFR | LLWESGSLLR | SEETKQNEGF | SLTAKGKGQG | TLSVVTVYHA |
1400:
KVKGKTTCKK | FDLRVTIKPA | PETAKKPQDA | KSSMILDICT | RYLGDVDATM |
1450:
SILDISMMTG | FIPDTNDLEL | LSSGVDRYIS | KYEMDKAFSN | KNTLIIYLEK |
1500:
ISHSEEDCLS | FKVHQFFNVG | LIQPGSVKVY | SYYNLEESCT | RFYHPEKDDG |
1550:
MLSKLCHNEM | CRCAEENCFM | HQSQDQVSLN | ERLDKACEPG | VDYVYKTKLT |
1600:
TIELSDDFDE | YIMTIEQVIK | SGSDEVQAGQ | ERRFISHVKC | RNALKLQKGK |
1650:
QYLMWGLSSD | LWGEKPNTSY | IIGKDTWVEH | WPEAEERQDQ | KNQKQCEDLG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Pig
Rat
Bovine
Rabbit
ELISA Kit for Rat Complement C3
ELISA Kit for Rat Complement C3
ELISA Kit for Rat Complement C3
ELISA Kit for Rat Complement C3
ELISA Kit for Rat Complement C3
ELISA Kit for Rat Complement C3
CLIA Kit for Rat Complement C3
CLIA Kit for Rat Complement C3
CLIA Kit for Rat Complement C3
CLIA Kit for Rat Complement C3
CLIA Kit for Rat Complement C3
CLIA Kit for Rat Complement C3
Polyclonal Antibody for Rat Complement C3
Polyclonal Antibody for Rat Complement C3
Polyclonal Antibody for Rat Complement C3
Polyclonal Antibody for Rat Complement C3
Polyclonal Antibody for Rat Complement C3
Polyclonal Antibody for Rat Complement C3
Monoclonal Antibody for Rat Complement C3
Monoclonal Antibody for Rat Complement C3
Monoclonal Antibody for Rat Complement C3
Monoclonal Antibody for Rat Complement C3
Monoclonal Antibody for Rat Complement C3
Monoclonal Antibody for Rat Complement C3
Protein for Rat Complement C3
Protein for Rat Complement C3
Protein for Rat Complement C3
Protein for Rat Complement C3
Protein for Rat Complement C3
Protein for Rat Complement C3
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Wistar .
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 568-592 AND 671-687;IDENTIFICATION OF C3A ANAPHYLATOXIN AND C3-BETA-C;FUNCTION
tissue :
Neutrophil .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 671-748
4.
"Nucleotide and deduced amino acid sequence of rat complement component C3a derived from Sprague-Dawley strain."
Wahrmann M.
,
Krieger S.
,
Liewehr A.
Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 671-748
strain :
Sprague-Dawley .
tissue :
Liver .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 960-969;X-RAY CRYSTALLOGRAPHY (1.44 ANGSTROMS) OF 1010-1286
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1316-1595