Protein name:
Cytochrome P450 26B1 ;
Alternative:
Cytochrome P450 retinoic acid-inactivating 2 (Cytochrome P450RAI-2) ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.
Subcellular Location:
Endoplasmic reticulum membrane
Peripheral membrane protein
Microsome membrane
Peripheral membrane protein
Protein Attributes:
50:
MLFEGLELVS | ALATLAACLV | SVTLLLAVSQ | QLWQLRWAAT | RDKSCKLPIP |
100:
KGSMGFPLIG | ETGHWLLQGS | GFQSSRREKY | GNVFKTHLLG | RPLIRVTGAE |
150:
NVRKILLGEH | QLVSTEWPRS | ARVLLGPNTV | ANSIGDIHRN | KRKVFSKIFS |
200:
HEALESYLPK | IQLVIQDTLR | AWSSQPEAIN | VYQEAQRLTF | RMAVRVLLGF |
250:
SIPEEDLGHL | FEVYQQFVEN | VFSLPVDLPF | SGYRRGIQAR | QILQKGLEKA |
300:
IREKLQCTQG | KDYSDALDIL | IESSKEHGKE | MTMQELKDGT | LELIFAAYAT |
350:
TASASTSLIM | QLLKHPAVLE | KLREELRAQG | LLHGGGCPCE | GTLRLDTLSS |
400:
LRYLDCVIKE | VMRLFTPVSG | GYRTVLQTFE | LDGFQIPKGW | SVMYSIRDTH |
450:
DTAPVFKDVN | VFDPDRFSQA | RSEDKDGRFH | YLPFGGGVRT | CLGKHLAKLF |
500:
LKVLAVELAS | TSRFELATRT | FPRITLVPVL | HPVDGLSVKF | FGLDSNQNEI |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Rat
Human
Mouse
ELISA Kit for Mouse Cytochrome P450 26B1
ELISA Kit for Mouse Cytochrome P450 26B1
ELISA Kit for Mouse Cytochrome P450 26B1
ELISA Kit for Mouse Cytochrome P450 26B1
CLIA Kit for Mouse Cytochrome P450 26B1
CLIA Kit for Mouse Cytochrome P450 26B1
CLIA Kit for Mouse Cytochrome P450 26B1
CLIA Kit for Mouse Cytochrome P450 26B1
Polyclonal Antibody for Mouse Cytochrome P450 26B1
Polyclonal Antibody for Mouse Cytochrome P450 26B1
Polyclonal Antibody for Mouse Cytochrome P450 26B1
Polyclonal Antibody for Mouse Cytochrome P450 26B1
Monoclonal Antibody for Mouse Cytochrome P450 26B1
Monoclonal Antibody for Mouse Cytochrome P450 26B1
Monoclonal Antibody for Mouse Cytochrome P450 26B1
Monoclonal Antibody for Mouse Cytochrome P450 26B1
Protein for Mouse Cytochrome P450 26B1
Protein for Mouse Cytochrome P450 26B1
Protein for Mouse Cytochrome P450 26B1
Protein for Mouse Cytochrome P450 26B1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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C57BL/6 .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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C57BL/6J .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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C57BL/6J .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN SKELETAL DEVELOPMENT