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Index > Protein center > HGF(Gene name) > Human
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  • HGF (Gene name),
  • Hepatocyte growth factor (Protein name ),  HGF_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    HGF(HPTA);
    Protein name:
    Hepatocyte growth factor;
    Alternative:
    Scatter factor(SF);Hepatopoietin-A;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Dimer of an alpha chain and a beta chain linked by a disulfide bond.
    Function:
    HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    728
    Sequence:
    50:
    MWVTKLLPAL | LLQHVLLHLL | LLPIAIPYAE | GQRKRRNTIH | EFKKSAKTTL | 
    100:
    IKIDPALKIK | TKKVNTADQC | ANRCTRNKGL | PFTCKAFVFD | KARKQCLWFP | 
    150:
    FNSMSSGVKK | EFGHEFDLYE | NKDYIRNCII | GKGRSYKGTV | SITKSGIKCQ | 
    200:
    PWSSMIPHEH | SFLPSSYRGK | DLQENYCRNP | RGEEGGPWCF | TSNPEVRYEV | 
    250:
    CDIPQCSEVE | CMTCNGESYR | GLMDHTESGK | ICQRWDHQTP | HRHKFLPERY | 
    300:
    PDKGFDDNYC | RNPDGQPRPW | CYTLDPHTRW | EYCAIKTCAD | NTMNDTDVPL | 
    350:
    ETTECIQGQG | EGYRGTVNTI | WNGIPCQRWD | SQYPHEHDMT | PENFKCKDLR | 
    400:
    ENYCRNPDGS | ESPWCFTTDP | NIRVGYCSQI | PNCDMSHGQD | CYRGNGKNYM | 
    450:
    GNLSQTRSGL | TCSMWDKNME | DLHRHIFWEP | DASKLNENYC | RNPDDDAHGP | 
    500:
    WCYTGNPLIP | WDYCPISRCE | GDTTPTIVNL | DHPVISCAKT | KQLRVVNGIP | 
    550:
    TRTNIGWMVS | LRYRNKHICG | GSLIKESWVL | TARQCFPSRD | LKDYEAWLGI | 
    600:
    HDVHGRGDEK | CKQVLNVSQL | VYGPEGSDLV | LMKLARPAVL | DDFVSTIDLP | 
    650:
    NYGCTIPEKT | SCSVYGWGYT | GLINYDGLLR | VAHLYIMGNE | KCSQHHRGKV | 
    700:
    TLNESEICAG | AEKIGSGPCE | GDYGGPLVCE | QHKMRMVLGV | IVPGRGCAIP | 
    728:
    NRPGIFVRVA | YYAKWIHKII | LTYKVPQS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    KEGG:
    SMR:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Hepatocyte growth factor
    Cat.:
    E0047h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Hepatocyte growth factor
    Cat.:
    E0047r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Hepatocyte growth factor
    Cat.:
    E0047m
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    MSDS:
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    96T
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    ELISA Kit for Human Hepatocyte growth factor
    Cat.:
    E0047b
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Hepatocyte growth factor
    Cat.:
    E0047d
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    MSDS:
    Please sign in first.
    Packing:
    96T
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    CLIA Kit for Human Hepatocyte growth factor
    Cat.:
    U0047d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Hepatocyte growth factor
    Cat.:
    U0047r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Hepatocyte growth factor
    Cat.:
    U0047m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Hepatocyte growth factor
    Cat.:
    U0047h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Hepatocyte growth factor
    Cat.:
    U0047b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Hepatocyte growth factor
    Cat.:
    P0047Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Hepatocyte growth factor
    Polyclonal Antibody for Human Hepatocyte growth factor
    Cat.:
    P0047Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Hepatocyte growth factor
    Cat.:
    P0047Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Hepatocyte growth factor
    Monoclonal Antibody for Human Hepatocyte growth factor
    Monoclonal Antibody for Human Hepatocyte growth factor
    Monoclonal Antibody for Human Hepatocyte growth factor
    Monoclonal Antibody for Human Hepatocyte growth factor
    Monoclonal Antibody for Human Hepatocyte growth factor
    Protein for Human Hepatocyte growth factor
    Protein for Human Hepatocyte growth factor
    Protein for Human Hepatocyte growth factor
    Protein for Human Hepatocyte growth factor
    Protein for Human Hepatocyte growth factor

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Placenta.
    2. 2.
      "Molecular cloning and expression of human hepatocyte growth factor."
      Nakamura T. , Nishizawa T. , Hagiya M. , Seki T. , Shimonishi M. , Sugimura A. , Tashiro K. , Shimizu S.
      Nature342:440-443(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 55-73 AND 495-520
      tissue: Liver.
    3. 3.
      "Isolation and expression of cDNA for different forms of hepatocyte growth factor from human leukocyte."
      Seki T. , Ihara I. , Sugimura A. , Shimonishi M. , Nishizawa T. , Asami O. , Hagiya M. , Nakamura T. , Shimizu S.
      Biochem. Biophys. Res. Commun.172:321-327(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Leukocyte.
    4. 4.
      "Organization of the human hepatocyte growth factor-encoding gene."
      Seki T. , Hagiya M. , Shimonishi M. , Nakamura T. , Shimizu S.
      Gene102:213-219(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    5. 5.
      "An alternatively processed mRNA generated from human hepatocyte growth factor gene."
      Miyazawa K. , Kitamura A. , Naka D. , Kitamura N.
      Eur. J. Biochem.197:15-22(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Placenta.
    6. 6.
      "A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor."
      Rubin J.S. , Chan A.M.-L. , Bottaro D.P. , Burgess W.H. , Taylor W.G. , Cech A.C. , Hirschfield D.W. , Wong J. , Miki T. , Finch P.W. , Aaronson S.A.
      Proc. Natl. Acad. Sci. U.S.A.88:415-419(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);PROTEIN SEQUENCE OF 583-592
      tissue: Lung fibroblast.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Embryonic fibroblast.
    8. 8.
      "Identification of a competitive HGF antagonist encoded by an alternative transcript."
      Chan A.M.-L. , Rubin J.S. , Bottaro D.P. , Hirschfield D.W. , Chedid M. , Aaronson S.A.
      Science254:1382-1385(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
    9. 9.
      "A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis."
      Hartmann G. , Naldini L. , Weidner K.M. , Sachs M. , Vigna E. , Comoglio P.M. , Birchmeier W.
      Proc. Natl. Acad. Sci. U.S.A.89:11574-11578(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);MUTAGENESIS OF ARG-494
    10. 10.
      "Hepatocyte growth factor (HGF)/NK1 is a naturally occurring HGF/scatter factor variant with partial agonist/antagonist activity."
      Cioce V. , Csaky K.G. , Chan A.M.-L. , Bottaro D.P. , Taylor W.G. , Jensen R. , Aaronson S.A. , Rubin J.S.
      J. Biol. Chem.271:13110-13115(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6)
    11. 11.
      NIEHS SNPs program
      Submitted (2003-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LYS-304 AND TYR-330
    12. 12.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    13. 14.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 5 AND 6)
      tissue: Brain.
    14. 15.
      "Structural organization and the transcription initiation site of the human hepatocyte growth factor gene."
      Miyazawa K. , Kitamura A. , Kitamura N.
      Biochemistry30:9170-9176(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 1-208 AND 249-695 (ISOFORM 1)
    15. 16.
      "Identification of the N-terminal residue of the heavy chain of both native and recombinant human hepatocyte growth factor."
      Yoshiyama Y. , Arakaki N. , Naka D. , Takahashi K. , Hirono S. , Kondo J. , Nakayama H. , Gohda E. , Kitamura N. , Tsubouchi H. , Ishii T. , Hishida T. , Daikuhara Y.
      Biochem. Biophys. Res. Commun.175:660-667(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SIGNAL SEQUENCE CLEAVAGE SITE;PYROGLUTAMATE FORMATION AT GLN-32
    16. 17.
      "Hepatocyte growth factor is linked by O-glycosylated oligosaccharide on the alpha chain."
      Shimizu N. , Hara H. , Sogabe T. , Sakai H. , Ihara I. , Inoue H. , Nakamura T. , Shimizu S.
      Biochem. Biophys. Res. Commun.189:1329-1335(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-476
    17. 18.
      "Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding."
      Lokker N.A. , Mark M.R. , Luis E.A. , Bennett G.L. , Robbins K.A. , Baker J.B. , Godowski P.J.
      EMBO J.11:2503-2510(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
    18. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN DFNB39
    19. 20.
      "SRPX2 is a novel chondroitin sulfate proteoglycan that is overexpressed in gastrointestinal cancer."
      Tanaka K. , Arao T. , Tamura D. , Aomatsu K. , Furuta K. , Matsumoto K. , Kaneda H. , Kudo K. , Fujita Y. , Kimura H. , Yanagihara K. , Yamada Y. , Okamoto I. , Nakagawa K. , Nishio K.
      PLoS ONE7:E27922-E27922(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SRPX2
    20. 21.
      "The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site."
      Zhou H. , Mazzulla M.J. , Kaufman J.D. , Stahl S.J. , Wingfield P.T. , Rubin J.S. , Bottaro D.P. , Byrd R.A.
      Structure6:109-116(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 31-127
    21. 22.
      "Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0-A resolution."
      Ultsch M. , Lokker N.A. , Godowski P.J. , de Vos A.M.
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