Gene name:
Sgms1 (Tmem23) ;
Protein name:
Phosphatidylcholine:ceramide cholinephosphotransferase 1 ;
Alternative:
Sphingomyelin synthase 1 ;Protein Mob ;Transmembrane protein 23 ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase (By similarity). Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. Required for cell growth.
Subcellular Location:
Golgi apparatus membrane
Multi-pass membrane protein
Protein Attributes:
50:
MLSARTMKEV | VYWSPKKVAD | WLLENAMPEY | CEPLEHFTGQ | DLINLTQEDF |
100:
KKPPLYRVSS | DNGQRLLDMI | ETLKMEHHME | AHKNGHANGH | LSIGVDIPNP |
150:
DGSFSIKTKP | NGMPNGFRKE | MIKIPMPEPE | RSQYPMEWGK | TFLAFLYALS |
200:
CFVLTTVMIS | VVHERVPPKE | VQPPLPDTFF | DHFNRVQWAF | SICEINGMIL |
250:
VGLWLFQWLL | LKYKSIISRR | FFCIVGTLYL | YRCITMYVTT | LPVPGMHFNC |
300:
SPKLFGDWEA | QVRRIMKLIA | GGGLSITGSH | NMCGDYLYSG | HTVMLTLTYL |
350:
FIKEYSPRRL | WWYHWICWLL | SVVGIFCILL | AHDHYTVDVV | VAYYITTRLF |
400:
WWYHTMANQQ | VLKEASQMNL | LARVWWYRPF | QYFEKNVQGI | VPRSYHWPFP |
419:
WPVVHLSRQV | KYSRLVNDT
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Pig
Mouse
Chicken
ELISA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
ELISA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
ELISA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
ELISA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
ELISA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
CLIA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
CLIA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
CLIA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
CLIA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
CLIA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
Polyclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
Polyclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
Polyclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
Polyclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
Polyclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
Monoclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
Monoclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
Monoclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
Monoclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
Monoclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
Protein for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
Protein for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
Protein for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
Protein for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
Protein for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);TISSUE SPECIFICITY;INDUCTION
strain :
BALB/c .
2.
"The transcriptional landscape of the mammalian genome."
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
strain :
C57BL/6J .
tissue :
Bone marrow macrophage .
tissue :
Embryo .
tissue :
Embryonic heart .
tissue :
Embryonic spinal cord .
tissue :
Embryonic stem cell .
tissue :
Testis .
tissue :
Urinary bladder .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6 .
strain :
FVB/N .
tissue :
Kidney .
tissue :
Olfactory epithelium .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE;FUNCTION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 1-84