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Index > Protein center > Rbm25(Gene name) > Mouse
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  • Rbm25 (Gene name),
  • RNA-binding protein 25 (Protein name ),  RBM25_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Rbm25;
    Protein name:
    RNA-binding protein 25;
    Alternative:
    RNA-binding motif protein 25;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with LUC7L3 and SRRM1 (By similarity). Specifically associates with functional splicing complexes, including Sm proteins and U1, U2, U4, U5 and U6 snRNAs (By similarity). Associates with exon junction complex (EJC) proteins, including APEX1, BAT1, NCBP1, RBM8A and RNPS1. Interaction with NCBP1 is RNA-dependent.
    Function:
    RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA.
    Subcellular Location:
    Nucleus speckle Cytoplasm Colocalizes predominantly, with SFRS2 and LUC7L3 splicing factors, in nuclear speckles. Cytoplasmic localization is faint.
    Protein Attributes:
    Sequence length:
    841
    Sequence:
    50:
    MSFPPHLNRP | PMGIPALPPG | IPPPQFPGFP | PPVPPGTPMI | PVPMSIMAPA | 
    100:
    PTVLVPTVSM | VGKHLGARKD | HPGLKLKEND | ENCGPTTTVF | VGNISEKASD | 
    150:
    MLIRQLLAKC | GLVLSWKRVQ | GASGKLQAFG | FCEYKEPEST | LRALRLLHDL | 
    200:
    QIGEKKLLVK | VDAKTKAQLD | EWKAKKKANG | VFKNARPETV | TNDDEEALDE | 
    250:
    ETKRRDQMIK | GAIEVLIREY | SSELNAPSQE | SDSHPRKKKK | EKKEDIFRRF | 
    300:
    PVAPLIPYPL | ITKEDINAIE | MEEDKRDLIS | REISKFRDTH | KKLEEEKGKK | 
    350:
    EKERQEIEKE | RRERERERER | ERERRERERE | REREREREKE | KERERERERD | 
    400:
    RDRDRTKERD | RDRERDRDRD | RERSSDRNKD | RSRSREKSRD | RERERERERE | 
    450:
    RERERERERE | RERERERERE | REREKDKKRD | REEDEEDAYE | RRKLERKLRE | 
    500:
    KEAAYQERLK | NWEIRERKKT | REYEKEAERE | EERRREMAKE | AKRLKEFLED | 
    550:
    YDDDRDDPKY | YRGSALQKRL | RDREKEMEAD | ERDRKREKEE | LEEIRQRLLA | 
    600:
    EGHPDPDAEL | QRMEQEAERR | RQPQIKQEPE | SEEEEEEKQE | KEEKREEPVE | 
    650:
    EEEEPEQKPC | LKPTLRPISS | APSVSSASGN | ATPNTPGDES | PCGIIIPHEN | 
    700:
    SPDQQQPEEH | RPKIGLSLKL | GASNSPGQPN | SVKRKKLPVD | SVFNKFEDED | 
    750:
    SDDVPRKRKL | VPLDYGEDDK | NATKGTVNTE | EKRKHIKSLI | EKIPTAKPEL | 
    800:
    FAYPLDWSIV | DSILMERRIR | PWINKKIIEY | IGEEEATLVD | FVCSKVMAHS | 
    841:
    SPQSILDDVA | MVLDEEAEVF | IVKMWRLLIY | ETEAKKIGLV | K
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    UniGene:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse RNA-binding protein 25
    ELISA Kit for Mouse RNA-binding protein 25
    CLIA Kit for Mouse RNA-binding protein 25
    CLIA Kit for Mouse RNA-binding protein 25
    Polyclonal Antibody for Mouse RNA-binding protein 25
    Polyclonal Antibody for Mouse RNA-binding protein 25
    Monoclonal Antibody for Mouse RNA-binding protein 25
    Monoclonal Antibody for Mouse RNA-binding protein 25
    Protein for Mouse RNA-binding protein 25
    Protein for Mouse RNA-binding protein 25

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Embryo.
      tissue: Embryonic eye.
      tissue: Embryonic spinal ganglion.
      tissue: Macrophage.
      tissue: Testis.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Colon.
      tissue: Embryonic germ cell.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-672 AND SER-698;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    4. 4.
      "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H. , Ye M. , Dong J. , Han G. , Jiang X. , Wu R. , Zou H.
      J. Proteome Res.7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-672;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    5. 5.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-578; SER-672 AND SER-698;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    6. 6.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-672;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    7. 7.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-135;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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