Protein name:
RNA-binding protein 25 ;
Alternative:
RNA-binding motif protein 25 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with LUC7L3 and SRRM1 (By similarity). Specifically associates with functional splicing complexes, including Sm proteins and U1, U2, U4, U5 and U6 snRNAs (By similarity). Associates with exon junction complex (EJC) proteins, including APEX1, BAT1, NCBP1, RBM8A and RNPS1. Interaction with NCBP1 is RNA-dependent.
Function:
RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA.
Subcellular Location:
Nucleus speckle
Cytoplasm
Colocalizes predominantly, with SFRS2 and LUC7L3 splicing factors, in nuclear speckles. Cytoplasmic localization is faint.
Protein Attributes:
50:
MSFPPHLNRP | PMGIPALPPG | IPPPQFPGFP | PPVPPGTPMI | PVPMSIMAPA |
100:
PTVLVPTVSM | VGKHLGARKD | HPGLKLKEND | ENCGPTTTVF | VGNISEKASD |
150:
MLIRQLLAKC | GLVLSWKRVQ | GASGKLQAFG | FCEYKEPEST | LRALRLLHDL |
200:
QIGEKKLLVK | VDAKTKAQLD | EWKAKKKANG | VFKNARPETV | TNDDEEALDE |
250:
ETKRRDQMIK | GAIEVLIREY | SSELNAPSQE | SDSHPRKKKK | EKKEDIFRRF |
300:
PVAPLIPYPL | ITKEDINAIE | MEEDKRDLIS | REISKFRDTH | KKLEEEKGKK |
350:
EKERQEIEKE | RRERERERER | ERERRERERE | REREREREKE | KERERERERD |
400:
RDRDRTKERD | RDRERDRDRD | RERSSDRNKD | RSRSREKSRD | RERERERERE |
450:
RERERERERE | RERERERERE | REREKDKKRD | REEDEEDAYE | RRKLERKLRE |
500:
KEAAYQERLK | NWEIRERKKT | REYEKEAERE | EERRREMAKE | AKRLKEFLED |
550:
YDDDRDDPKY | YRGSALQKRL | RDREKEMEAD | ERDRKREKEE | LEEIRQRLLA |
600:
EGHPDPDAEL | QRMEQEAERR | RQPQIKQEPE | SEEEEEEKQE | KEEKREEPVE |
650:
EEEEPEQKPC | LKPTLRPISS | APSVSSASGN | ATPNTPGDES | PCGIIIPHEN |
700:
SPDQQQPEEH | RPKIGLSLKL | GASNSPGQPN | SVKRKKLPVD | SVFNKFEDED |
750:
SDDVPRKRKL | VPLDYGEDDK | NATKGTVNTE | EKRKHIKSLI | EKIPTAKPEL |
800:
FAYPLDWSIV | DSILMERRIR | PWINKKIIEY | IGEEEATLVD | FVCSKVMAHS |
841:
SPQSILDDVA | MVLDEEAEVF | IVKMWRLLIY | ETEAKKIGLV | K
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse RNA-binding protein 25
ELISA Kit for Mouse RNA-binding protein 25
CLIA Kit for Mouse RNA-binding protein 25
CLIA Kit for Mouse RNA-binding protein 25
Polyclonal Antibody for Mouse RNA-binding protein 25
Polyclonal Antibody for Mouse RNA-binding protein 25
Monoclonal Antibody for Mouse RNA-binding protein 25
Monoclonal Antibody for Mouse RNA-binding protein 25
Protein for Mouse RNA-binding protein 25
Protein for Mouse RNA-binding protein 25
R&D Technical Data
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Precision
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Embryo .
tissue :
Embryonic eye .
tissue :
Embryonic spinal ganglion .
tissue :
Macrophage .
tissue :
Testis .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Colon .
tissue :
Embryonic germ cell .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-672 AND SER-698;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-672;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-578; SER-672 AND SER-698;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-672;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .
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Mol. Cell50:919-930(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-135;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .