Protein S100-B (Protein name
), S100B_BOVIN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
S100B;
Protein name:
Protein S100-B;
Alternative:
S-100 protein subunit beta;S-100 protein beta chain;S100 calcium-binding protein B;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer interacts with two molecules of CAPZA1. Interacts with AGER (By similarity). The S100B dimer interacts with two molecules of STK38.
Function:
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
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Precision
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Recovery
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Linearity
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References
1.
"Cloning, molecular and biochemical characterization of S100B from bovine retina." Burczynska B.B.
,
Duda T.
,
Venkataraman V.
,
Sharma R.K.
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: STRUCTURE BY NMR;FUNCTION;INTERACTION WITH STK38
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