SRD5A2 ELISA Kit for Human(Homo sapiens) | EIAab.comSRD5A2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SRD5A2(Gene name) > Human

SRD5A2 (Gene name),

3-oxo-5-alpha-steroid 4-dehydrogenase 2 (Protein name ), S5A2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SRD5A2;

Protein name:

3-oxo-5-alpha-steroid 4-dehydrogenase 2;

Alternative:

SR type 2;5 alpha-SR2;Type II 5-alpha reductase;Steroid 5-alpha-reductase 2(S5AR 2);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Subcellular Location:

Microsome membrane Multi-pass membrane protein Endoplasmic reticulum membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

254

Sequence:

50:

100:

150:

200:

250:

254:

PFIF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

264600

KEGG:

hsa:6716

Pfam:

PF02544

UniGene:

Hs.458345

STRING:

9606.ENSP00000233139

String:

P31213

Uniprot:

P31213

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ELISA Kit for Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Cat.:

E15128r

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96T

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ELISA Kit for Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Cat.:

E15128m

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Manual:

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96T

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ELISA Kit for Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Cat.:

E15128h

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96T

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ELISA Kit for Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Cat.:

E15128p

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Packing:

96T

CLIA Kit for Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Cat.:

U15128p

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Packing:

96T

CLIA Kit for Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Cat.:

U15128h

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MSDS:

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Packing:

96T

CLIA Kit for Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Cat.:

U15128r

Price:

Please sign in first.

MSDS:

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Packing:

96T

CLIA Kit for Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Cat.:

U15128m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Cat.:

P15128Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Cat.:

P15128Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Cat.:

P15128Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Monoclonal Antibody for Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Protein for Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism."
Andersson S. , Berman D.M. , Jenkins E.P. , Russell D.W.
Nature354:159-161(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Structure of human type II 5 alpha-reductase gene."
Labrie F. , Sugimoto Y. , Luu-The V. , Simard J. , Lachance Y. , Bachvarov D. , Leblanc G. , Durocher F. , Paquet N.
Endocrinology131:1571-1573(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

Schupp I.
Submitted (2007-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT LEU-89
tissue: Liver tumor.
4.

NIEHS SNPs program
Submitted (2005-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-49; LEU-89 AND VAL-113
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT LEU-89
8.

"Transcription of type II 5 alpha-reductase is up-regulated by SRY in human dermal papilla cells."
Nakanishi J. , Hibino T.
Submitted (2000-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-67
tissue: Placenta.
9.

"Molecular genetics of steroid 5 alpha-reductase 2 deficiency."
Thigpen A.E. , Davis D.L. , Milatovich A. , Mendonca B.B. , Imperato-Mcginley J. , Griffin J.E. , Francke U. , Wilson J.D. , Russell D.W.
J. Clin. Invest.90:799-809(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PPSH TRP-246
10.

"A new deletion of the 5-alpha-reductase type 2 gene in a Turkish family with 5-alpha-reductase deficiency."
Boudon C. , Lobaccaro J.-M. , Lumbroso S. , Ogur G. , Ocal G. , Belon C. , Sultan C.
Clin. Endocrinol. (Oxf.)43:183-188(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PPSH MET-157 DEL
11.

"5-alpha-reductase-2 gene mutations in the Dominican Republic."
Cai L.-Q. , Zhu Y.-S. , Katz M.D. , Herrera C. , Baez J. , DeFillo-Ricart M. , Shackleton C.H.L. , Imperato-McGinley J.
J. Clin. Endocrinol. Metab.81:1730-1735(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PPSH ASP-115; SER-183 AND TRP-246
12.

"Clinical, biochemical, and genetic findings in a large pedigree of male and female patients with 5-alpha-reductase 2 deficiency."
Hochberg Z. , Chayen R. , Reiss N. , Falik Z. , Makler A. , Munichor M. , Farkas A. , Goldfarb H. , Ohana N. , Hiort O.
J. Clin. Endocrinol. Metab.81:2821-2827(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PPSH GLN-55
13.

"Male pseudohermaphroditism resulting from a novel mutation in the human steroid 5 alpha-reductase type 2 gene (SRD5A2)."
Anwar R. , Gilbey S.G. , New J.P. , Markham A.F.
Mol. Pathol.50:51-52(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PPSH LYS-200
14.

"Homozygous mutation (A228T) in the 5-alpha-reductase type 2 gene in a boy with 5-alpha-reductase deficiency: genotype-phenotype correlations."
Nordenskjold A. , Magnus O. , Aagenaes O. , Knudtzon J.
Am. J. Med. Genet.80:269-272(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PPSH THR-228
15.

"Molecular characterization of 5-alpha-reductase type 2 deficiency and fertility in a Swedish family."
Nordenskjold A. , Ivarsson S.-A.
J. Clin. Endocrinol. Metab.83:3236-3238(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PPSH SER-196 AND ARG-231
16.

"Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA."
Makridakis N.M. , Ross R.K. , Pike M.C. , Crocitto L.E. , Kolonel L.N. , Pearce C.L. , Henderson B.E. , Reichardt J.K.V.
Lancet354:975-978(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THR-49
17.

"Identification of missense mutations in the SRD5A2 gene from patients with steroid 5alpha-reductase 2 deficiency."
Vilchis F. , Mendez J.P. , Canto P. , Lieberman E. , Chavez B.
Clin. Endocrinol. (Oxf.)52:383-387(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PPSH ASP-85; ASP-115; ARG-212; TYR-245 AND GLN-246
18.

"Uniparental disomy in steroid 5-alpha-reductase 2 deficiency."
Chavez B. , Valdez E. , Vilchis F.
J. Clin. Endocrinol. Metab.85:3147-3150(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PPSH ASP-197 AND ARG-212
19.

"Steroid 5-alpha reductase type II V89L substitution is not associated with risk of prostate cancer in a multiethnic population study."
Pearce C.L. , Makridakis N.M. , Ross R.K. , Pike M.C. , Kolonel L.N. , Henderson B.E. , Reichardt J.K.V.
Cancer Epidemiol. Biomarkers Prev.11:417-418(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-89
20.

"Micropenis and the 5alpha-reductase-2 (SRD5A2) gene: mutation and V89L polymorphism analysis in 81 Japanese patients."
Sasaki G. , Ogata T. , Ishii T. , Kosaki K. , Sato S. , Homma K. , Takahashi T. , Hasegawa T. , Matsuo N.
J. Clin. Endocrinol. Metab.88:3431-3436(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MICROPENIS GLN-227;VARIANT LEU-89
21.

"Comprehensive evaluation of the association between prostate cancer and genotypes/haplotypes in CYP17A1, CYP3A4, and SRD5A2."
Loukola A. , Chadha M. , Penn S.G. , Rank D. , Conti D.V. , Thompson D. , Cicek M. , Love B. , Bivolarevic V. , Yang Q. , Jiang Y. , Hanzel D.K. , Dains K. , Paris P.L. , Casey G. , Witte J.S.
Eur. J. Hum. Genet.12:321-332(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THR-49;LACK OF ASSOCIATION WITH PROSTATE CANCER
22.

"Clinical, biochemical and morphologic diagnostic markers in an infant male pseudohermaphrodite patient with compound heterozygous mutations (G115D/R246W) in SRD5A2 gene."
Fernandez-Cancio M. , Rodo J. , Andaluz P. , Martinez de Osaba M.J. , Rodriguez-Hierro F. , Esteban C. , Carrascosa A. , Audi L.
Horm. Res.62:259-264(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PPSH ASP-115 AND TRP-246
23.

"SRD5A2 gene analysis in an Italian population of under-masculinized 46,XY subjects."
Nicoletti A. , Baldazzi L. , Balsamo A. , Barp L. , Pirazzoli P. , Gennari M. , Radetti G. , Cacciari E. , Cicognani A.
Clin. Endocrinol. (Oxf.)63:375-380(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PPSH TRP-145; LEU-181; SER-196; PHE-235 AND GLN-246;VARIANTS THR-49 AND LEU-89
24.

"New mutations, hotspots, and founder effects in Brazilian patients with steroid 5alpha-reductase deficiency type 2."
Hackel C. , Oliveira L.E. , Ferraz L.F. , Tonini M.M. , Silva D.N. , Toralles M.B. , Stuchi-Perez E.G. , Guerra-Junior G.
J. Mol. Med.83:569-576(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PPSH ARG-126; ARG-158; SER-183; SER-196; ASP-207 AND TRP-246;VARIANTS THR-49 AND LEU-89
25.

"A novel missense mutation of 5-alpha reductase type 2 gene (SRD5A2) leads to severe male pseudohermaphroditism in a Turkish family."
Bahceci M. , Ersay A.R. , Tuzcu A. , Hiort O. , Richter-Unruh A. , Gokalp D.
Urology66:407-410(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PPSH ARG-123

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