SH3BP4 ELISA Kit for Human(Homo sapiens) | EIAab.comSH3BP4 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SH3BP4(Gene name) > Human

SH3BP4 (Gene name),

SH3 domain-binding protein 4 (Protein name ), SH3B4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SH3BP4(BOG25;EHB10;TTP);

Protein name:

SH3 domain-binding protein 4;

Alternative:

Transferrin receptor-trafficking protein;EH-binding protein 10;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer or homooligomer. Interacts with DNM2, EPS15, clathrin, the adapter protein complex 2/AP-2 and TFRC.

Function:

Functions in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis.

Subcellular Location:

Membrane clathrin-coated pit Cytoplasmic vesicle clathrin-coated vesicle Nucleus Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.

Protein Attributes:

Sequence length:

963

Sequence:

50:

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650:

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963:

AAFSPADQDD | FVI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:23677

Pfam:

PF07653

UniGene:

Hs.516777

String:

Q9P0V3

STRING:

9606.ENSP00000340237

Pfam:

PF00018

SMR:

Q9P0V3

MIM:

605611

Uniprot:

Q9P0V3

FOR

ELISA Kit for Human SH3 domain-binding protein 4

CLIA Kit for Human SH3 domain-binding protein 4

Polyclonal Antibody for Human SH3 domain-binding protein 4

Monoclonal Antibody for Human SH3 domain-binding protein 4

Protein for Human SH3 domain-binding protein 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning, chromosomal localization, and characterization of cDNA from a novel gene, SH3BP4, expressed by human corneal fibroblasts."
Dunlevy J.R. , Berryhill B.L. , Vergnes J.-P. , SundarRaj N. , Hassell J.R.
Genomics62:519-524(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: Corneal fibroblast.
2.

"TTP specifically regulates the internalization of the transferrin receptor."
Tosoni D. , Puri C. , Confalonieri S. , Salcini A.E. , De Camilli P. , Tacchetti C. , Di Fiore P.P.
Cell123:875-888(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION IN ENDOCYTOSIS;INTERACTION WITH AP-2; CLATHRIN; DNM2; EPS15 AND TFRC;OLIGOMERIZATION;PHOSPHORYLATION;SUBCELLULAR LOCATION;MUTAGENESIS OF TRP-92;VARIANTS THR-155 AND THR-197
tissue: Placenta.
3.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Eye.
5.

"Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module."
Salcini A.E. , Confalonieri S. , Doria M. , Santolini E. , Tassi E. , Minenkova O. , Cesareni G. , Pelicci P.G. , Di Fiore P.P.
Genes Dev.11:2239-2249(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-963 (ISOFORM 2);INTERACTION WITH EPS15
tissue: Fibroblast.
6.

"Nuclear and plasma membrane localization of SH3BP4 in retinal pigment epithelial cells."
Khanobdee K. , Kolberg J.B. , Dunlevy J.R.
Mol. Vis.10:933-942(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
7.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
8.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
9.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-637;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling."
Kim Y.M. , Stone M. , Hwang T.H. , Kim Y.G. , Dunlevy J.R. , Griffin T.J. , Kim D.H.
Mol. Cell46:833-846(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MTORC1 SIGNALING;INTERACTION WITH RRAGA; RRAGB; RRAGC AND RRAGD;MUTAGENESIS OF TRP-92

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