KNSTRN ELISA Kit for Human(Homo sapiens) | EIAab.comKNSTRN ELISA Kit for Human(Homo sapiens) | EIAab.com

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KNSTRN (Gene name),

Small kinetochore-associated protein (Protein name ), SKAP_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

KNSTRN(HSD11;C15orf23;SKAP;TRAF4AF1);

Protein name:

Small kinetochore-associated protein(SKAP);

Alternative:

Kinetochore-localized astrin/SPAG5-binding protein;Kinetochore-localized astrin-binding protein(Kinastrin);TRAF4-associated factor 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGOL2. Interacts with SPAG5. Directly binds to microtubules, although at relatively low affinity. Interacts with CENPE; this interaction greatly favors microtubule-binding.

Function:

Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments.

Subcellular Location:

Nucleus Chromosome Centromere Kinetochore Cytoplasm Cytoskeleton Spindle pole Colocalizes with microtubules around centrosomes in prophase and with the mitotic spindle at prometaphase and metaphase. From late prometaphase to anaphase, is highly concentrated on kinetochores. Located at the kinetochore-microtubule interface. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends.

Protein Attributes:

Sequence length:

316

Sequence:

50:

MAAPEAPPLD | RVFRTTWLST | ECDSHPLPPS | YRKFLFETQA | ADLAGGTTVA |

100:

AGNLLNESEK | DCGQDRRAPG | VQPCRLVTMT | SVVKTVYSLQ | PPSALSGGQP |

150:

ADTQTRATSK | SLLPVRSKEV | DVSKQLHSGG | PENDVTKITK | LRRENGQMKA |

200:

TDTATRRNVR | KGYKPLSKQK | SEEELKDKNQ | LLEAVNKQLH | QKLTETQGEL |

250:

KDLTQKVELL | EKFRDNCLAI | LESKGLDPAL | GSETLASRQE | STTDHMDSML |

300:

LLETLQEELK | LFNETAKKQM | EELQALKVKL | EMKEERVRFL | EQQTLCNNQV |

316:

NDLTTALKEM | EQLLEM

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

KEGG:

UniGene:

STRING:

9606.ENSP00000249776

Uniprot:

FOR

ELISA Kit for Human SKAP

ELISA Kit for Human SKAP

ELISA Kit for Human SKAP

CLIA Kit for Human SKAP

CLIA Kit for Human SKAP

CLIA Kit for Human SKAP

Polyclonal Antibody for Human SKAP

Polyclonal Antibody for Human SKAP

Polyclonal Antibody for Human SKAP

Monoclonal Antibody for Human SKAP

Monoclonal Antibody for Human SKAP

Monoclonal Antibody for Human SKAP

Protein for Human SKAP

Protein for Human SKAP

Protein for Human SKAP

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"A spermatogenesis related gene expressed in nucleus."
Cai C.L. , Liu N. , Lin W. , Miao S.Y. , Wang L.F.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Testis.
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Testis.
3.

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C. , Garber M. , Sharpe T. , Young S.K. , Rowen L. , O'Neill K. , Whittaker C.A. , Kamal M. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Kodira C.D. , Madan A. , Qin S. , Yang X. , Abbasi N. , Abouelleil A. , more...
Nature440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS GLU-40; LEU-75 AND SER-92
tissue: Kidney.
tissue: Ovary.
tissue: Testis.
5.

"Full-length cDNA libraries and normalization."
Li W.B. , Gruber C. , Jessee J. , Polayes D.
Submitted (2004-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-316 (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 55-316 (ISOFORM 2)
tissue: Neuroblastoma.
6.

Touji S. , Yano M. , Kobayasi A. , Tamai K.
Submitted (1996-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-316 (ISOFORM 1)
7.

"Analysis of differentially expressed genes in nitric oxide-exposed human monocytic cells."
Turpaev K. , Bouton C. , Diet A. , Glatigny A. , Drapier J.-C.
Free Radic. Biol. Med.38:1392-1400(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY NITRIC OXIDE
8.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
9.

"SKAP associates with kinetochores and promotes the metaphase-to-anaphase transition."
Fang L. , Seki A. , Fang G.
Cell Cycle8:2819-2827(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
10.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.

"The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment."
Dunsch A.K. , Linnane E. , Barr F.A. , Gruneberg U.
J. Cell Biol.192:959-968(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;IDENTIFICATION IN A COMPLEX WITH SPAG5; PLK1; DYNLL1 AND SGOL2;INTERACTION WITH SPAG5
12.

"CENP-E kinesin interacts with SKAP protein to orchestrate accurate chromosome segregation in mitosis."
Huang Y. , Wang W. , Yao P. , Wang X. , Liu X. , Zhuang X. , Yan F. , Zhou J. , Du J. , Ward T. , Zou H. , Zhang J. , Fang G. , Ding X. , Dou Z. , Yao X.
J. Biol. Chem.287:1500-1509(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CENPE;BINDING TO MICROTUBULES;SUBCELLULAR LOCATION;INDUCTION
13.

"Mitotic regulator SKAP forms a link between kinetochore core complex KMN and dynamic spindle microtubules."
Wang X. , Zhuang X. , Cao D. , Chu Y. , Yao P. , Liu W. , Liu L. , Adams G. , Fang G. , Dou Z. , Ding X. , Huang Y. , Wang D. , Yao X.
J. Biol. Chem.287:39380-39390(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH DSN1 AND MAPRE1
14.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma."
Lee C.S. , Bhaduri A. , Mah A. , Johnson W.L. , Ungewickell A. , Aros C.J. , Nguyen C.B. , Rios E.J. , Siprashvili Z. , Straight A. , Kim J. , Aasi S.Z. , Khavari P.A.
Nat. Genet.46:1060-1062(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SCC;VARIANT SCC PHE-24;FUNCTION;TISSUE SPECIFICITY
16.

"Small kinetochore associated protein (SKAP) promotes UV-induced cell apoptosis through negatively regulating pre-mRNA processing factor 19 (Prp19)."
Lu S. , Wang R. , Cai C. , Liang J. , Xu L. , Miao S. , Wang L. , Song W.
PLoS ONE9:E92712-E92712(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRPF19;SUBCELLULAR LOCATION

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