Gene name:
Spc25 (Spbc25) ;
Protein name:
Kinetochore protein Spc25 ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end.
Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.
Subcellular Location:
Nucleus
Chromosome
centromere
kinetochore
Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.
Protein Attributes:
50:
MGEDELALLN | QSINEFGDKF | RNRLDDNHSQ | VLGLRDAFKD | SMKAFSEKMS |
100:
LKLKEEERMT | EMILEYKNQL | CKQNKLIQEK | KENVLKMIAE | VKGKEQESEE |
150:
LTAKIQELKE | EYARKRETIS | TANKANEERL | KGLQKSADLY | RDYLGLEIRK |
200:
IHGNKLQFIF | TSIDPKNPES | PYMFSMSINE | AKEYEVYDSS | PHLECLAEFQ |
226:
EKVRKTNNFS | AFLANIRKAF | IAKVHN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Bovine
Mouse
ELISA Kit for Mouse Kinetochore protein Spc25
ELISA Kit for Mouse Kinetochore protein Spc25
ELISA Kit for Mouse Kinetochore protein Spc25
ELISA Kit for Mouse Kinetochore protein Spc25
CLIA Kit for Mouse Kinetochore protein Spc25
CLIA Kit for Mouse Kinetochore protein Spc25
CLIA Kit for Mouse Kinetochore protein Spc25
CLIA Kit for Mouse Kinetochore protein Spc25
Polyclonal Antibody for Mouse Kinetochore protein Spc25
Polyclonal Antibody for Mouse Kinetochore protein Spc25
Polyclonal Antibody for Mouse Kinetochore protein Spc25
Polyclonal Antibody for Mouse Kinetochore protein Spc25
Monoclonal Antibody for Mouse Kinetochore protein Spc25
Monoclonal Antibody for Mouse Kinetochore protein Spc25
Monoclonal Antibody for Mouse Kinetochore protein Spc25
Monoclonal Antibody for Mouse Kinetochore protein Spc25
Protein for Mouse Kinetochore protein Spc25
Protein for Mouse Kinetochore protein Spc25
Protein for Mouse Kinetochore protein Spc25
Protein for Mouse Kinetochore protein Spc25
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
strain :
C57BL/6J .
tissue :
Bone marrow .
tissue :
Embryo .
tissue :
Embryonic liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Retina .