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Index > Protein center > Sparc(Gene name) > Mouse
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  • Sparc (Gene name),
  • SPARC (Protein name ),  SPRC_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Sparc;
    Protein name:
    SPARC;
    Alternative:
    Osteonectin(ON);Basement-membrane protein 40(BM-40);Secreted protein acidic and rich in cysteine;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
    Subcellular Location:
    Secreted extracellular space extracellular matrix basement membrane In or around the basement membrane.
    Protein Attributes:
    Sequence length:
    302
    Sequence:
    50:
    MRAWIFFLLC | LAGRALAAPQ | QTEVAEEIVE | EETVVEETGV | PVGANPVQVE | 
    100:
    MGEFEDGAEE | TVEEVVADNP | CQNHHCKHGK | VCELDESNTP | MCVCQDPTSC | 
    150:
    PAPIGEFEKV | CSNDNKTFDS | SCHFFATKCT | LEGTKKGHKL | HLDYIGPCKY | 
    200:
    IAPCLDSELT | EFPLRMRDWL | KNVLVTLYER | DEGNNLLTEK | QKLRVKKIHE | 
    250:
    NEKRLEAGDH | PVELLARDFE | KNYNMYIFPV | HWQFGQLDQH | PIDGYLSHTE | 
    300:
    LAPLRAPLIP | MEHCTTRFFE | TCDLDNDKYI | ALEEWAGCFG | IKEQDINKDL | 
    302:
    VI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse SPARC
    Cat.:
    E0791h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse SPARC
    Cat.:
    E0791m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse SPARC
    Cat.:
    E0791r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse SPARC
    Cat.:
    E0791b
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse SPARC
    Cat.:
    E0791p
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse SPARC
    Cat.:
    E0791c
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse SPARC
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse SPARC
    Cat.:
    U0791b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse SPARC
    Cat.:
    U0791p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse SPARC
    Cat.:
    U0791c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse SPARC
    Cat.:
    U0791r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse SPARC
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse SPARC
    Cat.:
    U0791m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse SPARC
    Cat.:
    U0791h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Mouse SPARC
    Polyclonal Antibody for Mouse SPARC
    Cat.:
    P0791Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse SPARC
    Polyclonal Antibody for Mouse SPARC
    Polyclonal Antibody for Mouse SPARC
    Cat.:
    P0791Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse SPARC
    Polyclonal Antibody for Mouse SPARC
    Cat.:
    P0791Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse SPARC
    Monoclonal Antibody for Mouse SPARC
    Monoclonal Antibody for Mouse SPARC
    Monoclonal Antibody for Mouse SPARC
    Monoclonal Antibody for Mouse SPARC
    Monoclonal Antibody for Mouse SPARC
    Monoclonal Antibody for Mouse SPARC
    Protein for Mouse SPARC
    Protein for Mouse SPARC
    Protein for Mouse SPARC
    Protein for Mouse SPARC
    Protein for Mouse SPARC
    Protein for Mouse SPARC
    Protein for Mouse SPARC

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    References
    1. 1.
      "Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin)."
      Lankat-Buttgereit B. , Mann K. , Deutzmann R. , Timpl R. , Krieg T.
      FEBS Lett.236:352-356(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE;PARTIAL PROTEIN SEQUENCE
      tissue: Placenta.
    2. 2.
      "Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000."
      Mason I.J. , Taylor A. , Williams J.G. , Sage H. , Hogan B.L.M.
      EMBO J.5:1465-1472(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Characterization of the mouse SPARC/osteonectin gene. Intron/exon organization and an unusual promoter region."
      McVey J.H. , Nomura S. , Kelly P. , Mason I.J. , Hogan B.L.M.
      J. Biol. Chem.263:11111-11116(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary gland.
    5. 5.
      "Solubilization of protein BM-40 from a basement membrane tumor with chelating agents and evidence for its identity with osteonectin and SPARC."
      Mann K. , Deutzmann R. , Paulsson M. , Timpl R.
      FEBS Lett.218:167-172(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 18-37 AND 215-234
    6. 6.
      "Calcium binding domains and calcium-induced conformational transition of SPARC/BM-40/osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues."
      Engel J. , Taylor W. , Paulsson M. , Sage H. , Hogan B.L.M.
      Biochemistry26:6958-6965(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;CALCIUM-BINDING;SUBCELLULAR LOCATION
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