SPARC (Protein name
), SPRC_RABIT from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
SPARC;
Protein name:
SPARC;
Alternative:
Osteonectin(ON);Basement-membrane protein 40(BM-40);Secreted protein acidic and rich in cysteine;
Organism:
Rabbit (Oryctolagus cuniculus).
General Annotation
Sub Unit:
N/A
Function:
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
basement membrane
In or around the basement membrane.
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Precision
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Recovery
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Linearity
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References
1.
"Differential gene expression of matrix metalloproteinases-1, -3, -13 and aggrecanases-1, -2 in a rabbit model of osteoarthritis." Bluteau G.
,
Mathieu P.
,
Conrozier T.
,
Vignon E.
,
Herbage D.
,
Mallein-Gerin F.
Submitted (2000-03) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]
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Cited for: PROTEIN SEQUENCE OF 18-27;TISSUE SPECIFICITY;INDUCTION