Src ELISA Kit for Mouse(Mus musculus) | EIAab.comSrc ELISA Kit for Mouse(Mus musculus)

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Src (Gene name),

Neuronal proto-oncogene tyrosine-protein kinase Src (Protein name ), SRC_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Src;

Protein name:

Neuronal proto-oncogene tyrosine-protein kinase Src;

Alternative:

pp60c-src(p60-Src);Proto-oncogene c-Src;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2 (By similarity). Interacts with DDEF1/ASAP1 via its SH3 domain. Interacts with CCPG1. Interacts with the cytoplasmic domain of MUC1, phosphorylates it and increases binding of MUC1 with beta-catenin (By similarity). Interacts with RALGPS1 via its SH3 domain (By similarity). Interacts with CAV2 (tyrosine phosphorylated form) (By similarity). Interacts (via the SH3 domain and the protein kinase domain) with ARRB1; the interaction is independent of the phosphorylation state of SRC C-terminus (By similarity). Interacts with ARRB2. Interacts with ARRB1. Interacts with SRCIN1 (By similarity). Interacts with SRCIN1. Interacts with NDFIP2 and more weakly with NDFIP1. Interacts with PIK3CA and/or PIK3C2B, PTK2, ESR1 (dimethylated on arginine) and FAK. Interacts (via SH2 and SH3 domain) with TNK2. Interacts (via protein kinase domain) with the tyrosine phosphorylated form of RUNX3 (via runt domain). Interacts with TRAF3 (via RING-type zinc finger domain). Interacts with DDX58, MAVS and TBK1. Interacts (via SH2 domain) with GNB2L1/RACK1; the interaction is enhanced by tyrosine phosphorylation of GNB2L1 and inhibits SRC activity (By similarity). Interacts (via SH2 domain) with the 'Tyr-402' phosphorylated form of PTK2B. Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2A, SRC, SHC1, GAP43 and CTTN. Interacts with EPHB1; activates the MAPK/ERK cascade to regulate cell migration.

Function:

Non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins, by PTK2B, it phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (By similarity). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-737'. Enhances DDX58/RIG-I-elicited antiviral signaling.

Subcellular Location:

Cell membrane Mitochondrion inner membrane

Protein Attributes:

Sequence length:

541

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

541:

DLMCQCWRKE | PEERPTFEYL | QAFLEDYFTS | TEPQYQPGEN | L

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:20779

Pfam:

PF07714

String:

P05480

UniGene:

Mm.22845

SMR:

P05480

STRING:

10090.ENSMUSP00000105155

Uniprot:

P05480

FOR

ELISA Kit for Mouse Neuronal proto-oncogene tyrosine-protein kinase Src

CLIA Kit for Mouse Neuronal proto-oncogene tyrosine-protein kinase Src

Polyclonal Antibody for Mouse Neuronal proto-oncogene tyrosine-protein kinase Src

Monoclonal Antibody for Mouse Neuronal proto-oncogene tyrosine-protein kinase Src

Protein for Mouse Neuronal proto-oncogene tyrosine-protein kinase Src

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Neuronal pp60c-src contains a six-amino acid insertion relative to its non-neuronal counterpart."
Martinez R. , Mathey-Prevot B. , Bernards A. , Baltimore D.
Science237:411-415(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BALB/c.
2.

"Characterization of quantitative trait loci influencing growth and adiposity using congenic mouse strains."
Farber C.R. , Corva P.M. , Medrano J.F.
Submitted (2005-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: CAST/EiJ.
tissue: Brain.
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor."
Courtneidge S.A. , Dhand R. , Pilat D. , Twamley G.M. , Waterfield M.D. , Roussel M.F.
EMBO J.12:943-950(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CSF1R
6.

"Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor."
Muthuswamy S.K. , Muller W.J.
Oncogene11:271-279(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ERBB2
7.

"Activation of Src-family protein tyrosine kinases and phosphatidylinositol 3-kinase in 3T3-L1 mouse preadipocytes by interleukin-11."
Fuhrer D.K. , Yang Y.C.
Exp. Hematol.24:195-203(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN IL11-SIGNALING
8.

"Bombesin, bradykinin, vasopressin, and phorbol esters rapidly and transiently activate Src family tyrosine kinases in Swiss 3T3 cells. Dissociation from tyrosine phosphorylation of p125 focal adhesion kinase."
Rodriguez-Fernandez J.L. , Rozengurt E.
J. Biol. Chem.271:27895-27901(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
9.

"c-Src activates both STAT1 and STAT3 in PDGF-stimulated NIH3T3 cells."
Cirri P. , Chiarugi P. , Marra F. , Raugei G. , Camici G. , Manao G. , Ramponi G.
Biochem. Biophys. Res. Commun.239:493-497(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH STAT1
10.

"ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src."
Brown M.T. , Andrade J. , Radhakrishna H. , Donaldson J.G. , Cooper J.A. , Randazzo P.A.
Mol. Cell. Biol.18:7038-7051(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DDEF1/ASAP1
11.

"N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling."
Cavallaro U. , Niedermeyer J. , Fuxa M. , Christofori G.
Nat. Cell Biol.3:650-657(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH NCAM1; CDH2; PLCG1; FRS2; FGFR4; SHC1; GAP43 AND CTTN
12.

"The role of c-Src in platelet-derived growth factor alpha receptor internalization."
Avrov K. , Kazlauskas A.
Exp. Cell Res.291:426-434(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDGFRA
13.

"Regulation of cytochrome c oxidase activity by c-Src in osteoclasts."
Miyazaki T. , Neff L. , Tanaka S. , Horne W.C. , Baron R.
J. Cell Biol.160:709-718(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
14.

"EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis."
Vindis C. , Cerretti D.P. , Daniel T.O. , Huynh-Do U.
J. Cell Biol.162:661-671(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPHB1
15.

"Src kinase activity is essential for osteoclast function."
Miyazaki T. , Sanjay A. , Neff L. , Tanaka S. , Horne W.C. , Baron R.
J. Biol. Chem.279:17660-17666(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PTK2B/PYK2
16.

"Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2."
Heiss E. , Masson K. , Sundberg C. , Pedersen M. , Sun J. , Bengtsson S. , Ronnstrand L.
Blood108:1542-1550(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FLT3
17.

"Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs."
Kostenko E.V. , Olabisi O.O. , Sahay S. , Rodriguez P.L. , Whitehead I.P.
Mol. Cell. Biol.26:8964-8975(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CCPG1
18.

"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-192;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
19.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance."
Luan B. , Zhao J. , Wu H. , Duan B. , Shu G. , Wang X. , Li D. , Jia W. , Kang J. , Pei G.
Nature457:1146-1149(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB2
21.

"Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Src."
Lu K.K. , Trcka D. , Bendeck M.P.
Cardiovasc. Pathol.20:71-76(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DDR1
22.

"Regulation, substrates and functions of src."
Brown M.T. , Cooper J.A.
Biochim. Biophys. Acta1287:121-149(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
23.

"Cellular functions regulated by Src family kinases."
Thomas S.M. , Brugge J.S.
Annu. Rev. Cell Dev. Biol.13:513-609(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
24.

"Novel regulation and function of Src tyrosine kinase."
Ma Y.C. , Huang X.Y.
Cell. Mol. Life Sci.59:456-462(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION

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