Gene name:
Stab2 (Feel2;Hare) ;
Protein name:
Stabilin-2 ;
Alternative:
Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2 (FEEL-2) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with heparin, alpha-M/beta-2 integrin (ITGAM and ITGB2), and thymosin beta 4 (TMSB4X) (By similarity). Interacts with GULP1. Associates with clathrin and adapter protein AP-2; in liver sinusoidal endothelial cells (LSECs).
Function:
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed short form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.
Subcellular Location:
Cytoplasm
Cell membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MARSKLLLGK | LLPLILIFLG | LLVQNACSPT | EAPELTKRCD | KKSTLTIKTE |
100:
CQSCSVNIAV | KCPDGYIKIT | NGTVGVRDCR | YSLKIQSYVL | DIPGCRHICR |
150:
KDYLQPQCCP | GHWGPDCMEC | PGGARAPCGG | RGVCDEGMEG | TGSCSCRAGF |
200:
RGTACENCAA | EDVFGPNCSA | VCSCVHGVCN | SGISGDGTCE | CLSAYRGPRC |
250:
DKPIPECAAL | LCPENSRCSP | SSKDETKLQC | KCLPSYKGDG | QTCKPINPCL |
300:
KNVCHPHASC | SYLGPNRHSC | VCQKGYQGDG | QVCLPVDPCQ | TSYGNCPTKS |
350:
TVCRYDGPGQ | SHCECKEHYR | NFVPGVGCSM | TDICESKNPC | HKNANCSTVS |
400:
PGQTQCTCQK | GYVGDGLNCY | GNIMQRLREL | NTEPRGMWQG | QLTSFISILD |
450:
RTYAWPLSNL | GPFTVLLPSD | KGLKGVDVKE | LLMDKEAARY | FVKLHIIAGQ |
500:
MSTEQMYNLD | TFYTLTGKSG | EIINKDKDNQ | LKLKLYGSKI | VQIIQGNIVA |
550:
SNGLVHILDR | AMDKIEPTLE | SNPQQTIMTM | LQPRYGKFRS | LLEKTNVGQA |
600:
LEKGGIDEPY | TIFVPSNEAL | SNMTAGVLDY | LLSPEGSRKL | LELVRYHIVA |
650:
FTQLEVATLV | STLHIRSMAN | QIITFNISSK | GQILANNVAV | DETEVAAKNG |
700:
RIYTLTGVLI | PPSILPILPH | RCNETKREMK | LGTCVRCFMK | NWSKCPTNSE |
750:
PTAIFTNKCF | YGSRAWNLKI | GCARYCDVTV | EIPRCCKGFF | GPDCNPCPGG |
800:
FMNPCSGNGQ | CIDGLGGNGT | CICEDGFQGS | RCQFCSKPNR | YGPQCNRTCQ |
850:
CVHGICDNRL | DSDGSCLPGT | CREGTAGRFC | DKQTSACGPY | MQFCHIHATC |
900:
EYSNETASCV | CNDGYEGDGT | LCSKKDPCLG | STSRGGCSPN | AECIQASTGT |
950:
YSCVCQRGWT | GNGRDCVEIN | SCLLPSSGGC | HDNATCLYVG | PGQNECECKK |
1000:
GFRGNGIDCE | PIISCLEQIE | KCHPLATCQY | TLSGVWSCVC | QEGYEGNGVL |
1050:
CYGNVLMELS | FLSEAAVFYQ | WINNASLQSM | LSATSNLTVL | VPSLQAIKDM |
1100:
DQNEKSFWLS | RNNIPALIKY | HTLLGTYRVA | DLQTLPSSHM | LATSLQGSFL |
1150:
RLDKADGNIT | IEGASFVDGD | NAATNGVVHI | INKVLIPQRG | LTGSLPSLLT |
1200:
RLEQMPDYSI | FRGYIIHYNL | ASAIEAADAY | TVFVPNNEAI | ESYIREKKAT |
1250:
SLKEDILQYH | VVLGEKLLRN | DLHNGMHRET | MLGFSYLLAF | FLHNDQLYVN |
1300:
EAPINYTNVA | TDKGVIHGLE | KVLEIKKNRC | DNNDTIIVRG | KCGKCSQQTL |
1350:
CPLETKPLSE | TRKCIYSVYF | MGKRSIFIGC | QLQCVRTIIT | SACCAGFFGP |
1400:
QCQACPGKGQ | NVCSGNGFCL | DGVNGTGTCE | CEQGFNGTAC | ETCTEGKYGI |
1450:
HCDQACSCVH | GRCNQGPSGD | GSCDCDVGWR | GVKCDSEITT | DNCNGTCHTS |
1500:
ANCLLDPDGK | ASCKCAAGFQ | GNGTVCTAIN | ACEISNGGCS | AKADCKRTIP |
1550:
GSRVCVCKAG | YTGDGIVCLE | INPCLENHGG | CDRHAECTQT | GPNQAVCNCL |
1600:
PKYTGDGKVC | TLINVCLTNN | GGCSPFAFCN | HTEQDQRTCT | CKPDYTGDGI |
1650:
VCRGSIHSEL | PKNPSTSQYF | FQLQEHAVQE | LAGPGPFTVF | VPSSDSFNSE |
1700:
SKLKVWDKQG | LMSQILRYHV | VACQQLLLEN | LKVITSATTL | QGEPISISVS |
1750:
QDTVLINKKA | KVLSSDIIST | NGVIHVIDTL | LSPQNLLITP | KGASGRVLLN |
1800:
LTTVAANHGY | TKFSKLIQDS | GLLKVITDPM | HTPVTLFWPT | DKALQALPQE |
1850:
QQDFLFNEDN | KDKLKAYLKF | HVIRDTMALA | SDLPRSASWK | TLQGSELSVR |
1900:
CGTGSDVGEL | FLNGQMCRII | QRRLLFDGGV | AYGIDCLLMD | PTEGGRCDTF |
1950:
TTFNIPGECG | SCFSTPRCPL | QSKPKGVRKK | CIYNPLPFRR | DVEGCQNLCT |
2000:
LVVHVPRCCS | GYFMPDCQAC | PGGPDTPCNN | RGMCYDQYKP | TGQCQCHTGF |
2050:
NGTACELCLP | GRFGPDCQPC | GCSEHGQCDE | GITGSGQCLC | EAGWTGRFCD |
2100:
APTVVIPVCI | PACSMHATCM | ENNTCVCNLN | YEGDGITCTV | VDFCKQNNGG |
2150:
CAKVAKCSQK | GTQVSCSCQK | GYKGDGHSCT | EIDPCANGVN | GGCHEHATCR |
2200:
MTGPGKQKCE | CKSHYVGDGR | DCEPEQLPLD | RCLQDNGQCH | PDANCVDLHF |
2250:
QDTTVGVFHL | RSPLGQYKLT | FDKAKEACAK | EAASIATYNQ | LSYAQKAKYH |
2300:
LCSAGWLESG | RVAYPTIYAS | KKCANIVGIV | DYGTRTNKSE | MWDVFCYRMK |
2350:
DVNCTCKAGY | VGDGFSCNGN | LLQVLMSFPS | LTNFLTEVLV | FSRSSAQGRA |
2400:
FLKHLTDLSI | SGTLFVPQNS | GLPKNKSLSG | RDIEHHLTNV | NVSFYDDLVN |
2450:
GTVLKTRLGS | QLLITSSQDQ | LHQEARFVDG | RAILQWDIIA | SNGVLHIISE |
2500:
PLKAPPTAAT | AAHSGLGTGI | FCAVVLVTGA | IALAAYSYFR | LNQRTTGFRR |
2550:
FESEDDIDAL | AFGKQQPESI | TNPLYETSTP | AAPEPSCDPF | TDSGERELEN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Mouse Stabilin-2
ELISA Kit for Mouse Stabilin-2
ELISA Kit for Mouse Stabilin-2
CLIA Kit for Mouse Stabilin-2
CLIA Kit for Mouse Stabilin-2
CLIA Kit for Mouse Stabilin-2
Polyclonal Antibody for Mouse Stabilin-2
Polyclonal Antibody for Mouse Stabilin-2
Polyclonal Antibody for Mouse Stabilin-2
Monoclonal Antibody for Mouse Stabilin-2
Monoclonal Antibody for Mouse Stabilin-2
Monoclonal Antibody for Mouse Stabilin-2
Protein for Mouse Stabilin-2
Protein for Mouse Stabilin-2
Protein for Mouse Stabilin-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues."
Politz O.
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Gratchev A.
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McCourt P.A.G.
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Guillot P.
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Biochem. J.362:155-164(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
BALB/c .
tissue :
Liver .
2.
"The transcriptional landscape of the mammalian genome."
Carninci P.
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Kasukawa T.
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1666-2559
strain :
C57BL/6J .
tissue :
Diencephalon .
3.
"FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products."
Tamura Y.
,
Adachi H.
,
Osuga J.
,
Ohashi K.
,
Yahagi N.
,
Sekiya M.
,
Okazaki H.
,
Tomita S.
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Iizuka Y.
,
Shimano H.
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Nagai R.
,
Kimura S.
,
Tsujimoto M.
,
Ishibashi S.
J. Biol. Chem.278:12613-12617(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
5.
"Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding."
Hansen B.
,
Longati P.
,
Elvevold K.
,
Nedredal G.-I.
,
Schledzewski K.
,
Olsen R.
,
Falkowski M.
,
Kzhyshkowska J.
,
Carlsson F.
,
Johansson S.
,
Smedsroed B.
,
Goerdt S.
,
Johansson S.
,
McCourt P.
Exp. Cell Res.303:160-173(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH CLATHRIN AND AP2;SUBCELLULAR LOCATION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2503;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH GULP1