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Sun1 (Gene name),

SUN domain-containing protein 1 (Protein name ), SUN1_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

Sun1(Unc84a);

Protein name:

SUN domain-containing protein 1;

Alternative:

Sad1/unc-84 protein-like 1;Protein unc-84 homolog A;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Dimers and tetramers. Component of LINC complexes composed of SUN domain-containing proteins SUN1 or SUN2 coupled to KASH domain-containing proteins (SYNE1, SYNE2 or SYNE3), also called nesprins. Interacts with NAT10 (By similarity). Interacts with EMD, LMNA, SYNE2 and TSNAX. Associates with the nuclear pore complex (NPC).

Function:

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs).

Subcellular Location:

Nucleus inner membrane Single-pass type II membrane protein

Protein Attributes:

Sequence length:

913

Sequence:

50:

MDFSRLHTYT | PPQCVPENTG | YTYALSSSYS | SDALDFETEH | KLEPVFDSPR |

100:

MSRRSLRLVT | TASYSSGDSQ | AIDSHISTSR | ATPAKGRETR | TVKQRRSASK |

150:

PAFSINHLSG | KGLSSSTSHD | SSCSLRSATV | LRHPVLDESL | IREQTKVDHF |

200:

WGLDDDGDLK | GGNKAATQGN | GELAAEVASS | NGYTCRDCRM | LSARTDALTA |

250:

HSAIHGTTSR | VYSRDRTLKP | RGVSFYLDRT | LWLAKSTSSS | FASFIVQLFQ |

300:

VVLMKLNFET | YKLKGYESRA | YESQSYETKS | HESEAHLGHC | GRMTAGELSR |

350:

VDGESLCDDC | KGKKHLEIHT | ATHSQLPQPH | RVAGAMGRLC | IYTGDLLVQA |

400:

LRRTRAAGWS | VAEAVWSVLW | LAVSAPGKAA | SGTFWWLGSG | WYQFVTLISW |

450:

LNVFLLTRCL | RNICKVFVLL | LPLLLLLGAG | VSLWGQGNFF | SLLPVLNWTA |

500:

MQPTQRVDDS | KGMHRPGPLP | PSPPPKVDHK | ASQWPQESDM | GQKVASLSAQ |

550:

CHNHDERLAE | LTVLLQKLQI | RVDQVDDGRE | GLSLWVKNVV | GQHLQEMGTI |

600:

EPPDAKTDFM | TFHHDHEVRL | SNLEDVLRKL | TEKSEAIQKE | LEETKLKAGS |

650:

RDEEQPLLDR | VQHLELELNL | LKSQLSDWQH | LKTSCEQAGA | RIQETVQLMF |

700:

SEDQQGGSLE | WLLEKLSSRF | VSKDELQVLL | HDLELKLLQN | ITHHITVTGQ |

750:

APTSEAIVSA | VNQAGISGIT | EAQAHIIVNN | ALKLYSQDKT | GMVDFALESG |

800:

GGSILSTRCS | ETYETKTALL | SLFGVPLWYF | SQSPRVVIQP | DIYPGNCWAF |

850:

KGSQGYLVVR | LSMKIYPTTF | TMEHIPKTLS | PTGNISSAPK | DFAVYGLETE |

900:

YQEEGQPLGR | FTYDQEGDSL | QMFHTLERPD | QAFQIVELRV | LSNWGHPEYT |

913:

CLYRFRVHGE | PIQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

STRING:

10090.ENSMUSP00000056655

UniGene:

KEGG:

SMR:

Pfam:

Uniprot:

FOR

ELISA Kit for Mouse SUN domain-containing protein 1

ELISA Kit for Mouse SUN domain-containing protein 1

CLIA Kit for Mouse SUN domain-containing protein 1

CLIA Kit for Mouse SUN domain-containing protein 1

Polyclonal Antibody for Mouse SUN domain-containing protein 1

Polyclonal Antibody for Mouse SUN domain-containing protein 1

Monoclonal Antibody for Mouse SUN domain-containing protein 1

Monoclonal Antibody for Mouse SUN domain-containing protein 1

Protein for Mouse SUN domain-containing protein 1

Protein for Mouse SUN domain-containing protein 1

R&D Technical Data

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Precision

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Recovery

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Linearity

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References

1.

"Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome."
Wang Q. , Du X. , Cai Z. , Greene M.I.
DNA Cell Biol.25:554-562(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);SUBUNIT;SUBCELLULAR LOCATION;ASSOCIATION WITH THE CENTROSOME;TISSUE SPECIFICITY
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
strain: C57BL/6J.
tissue: Cerebellum.
tissue: Embryo.
tissue: Placenta.
tissue: Skin.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: C57BL/6.
strain: FVB/N.
strain: FVB/N-3.
tissue: Brain.
tissue: Mammary tumor.
4.

"Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X."
Bray J.D. , Chennathukuzhi V.M. , Hecht N.B.
Genomics79:799-808(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 605-913;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH TSNAX
tissue: Testis.
5.

"Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane."
Dreger M. , Bengtsson L. , Schoeneberg T. , Otto H. , Hucho F.
Proc. Natl. Acad. Sci. U.S.A.98:11943-11948(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION
6.

"Coupling of the nucleus and cytoplasm: role of the LINC complex."
Crisp M. , Liu Q. , Roux K. , Rattner J.B. , Shanahan C. , Burke B. , Stahl P.D. , Hodzic D.
J. Cell Biol.172:41-53(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE LINC COMPLEX;INTERACTION WITH LAMINS AND SYNE2;SUBCELLULAR LOCATION;TOPOLOGY;TISSUE SPECIFICITY
7.

"SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton."
Haque F. , Lloyd D.J. , Smallwood D.T. , Dent C.L. , Shanahan C.M. , Fry A.M. , Trembath R.C. , Shackleton S.
Mol. Cell. Biol.26:3738-3751(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TOPOLOGY;INTERACTION WITH LMNA; SYNE1 AND SYNE2
8.

"SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice."
Ding X. , Xu R. , Yu J. , Xu T. , Zhuang Y. , Han M.
Dev. Cell12:863-872(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Functional association of Sun1 with nuclear pore complexes."
Liu Q. , Pante N. , Misteli T. , Elsagga M. , Crisp M. , Hodzic D. , Burke B. , Roux K.J.
J. Cell Biol.178:785-798(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;ASSOCIATION WITH THE NUCLEAR PORE COMPLEX
10.

"Sun1 forms immobile macromolecular assemblies at the nuclear envelope."
Lu W. , Gotzmann J. , Sironi L. , Jaeger V.M. , Schneider M. , Luke Y. , Uhlen M. , Szigyarto C.A. , Brachner A. , Ellenberg J. , Foisner R. , Noegel A.A. , Karakesisoglou I.
Biochim. Biophys. Acta1783:2415-2426(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TOPOLOGY;SUBUNIT
11.

"Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA."
Chi Y.H. , Cheng L.I. , Myers T. , Ward J.M. , Williams E. , Su Q. , Faucette L. , Wang J.Y. , Jeang K.T.
Development136:965-973(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Cohesin SMC1beta protects telomeres in meiocytes."
Adelfalk C. , Janschek J. , Revenkova E. , Blei C. , Liebe B. , Gob E. , Alsheimer M. , Benavente R. , de Boer E. , Novak I. , Hoog C. , Scherthan H. , Jessberger R.
J. Cell Biol.187:185-199(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;ASSOCIATION WITH TELOMERES
13.

"Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins."
Ostlund C. , Folker E.S. , Choi J.C. , Gomes E.R. , Gundersen G.G. , Worman H.J.
J. Cell Sci.122:4099-4108(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH LMNA AND SYN2
14.

"SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice."
Zhang X. , Lei K. , Yuan X. , Wu X. , Zhuang Y. , Xu T. , Xu R. , Han M.
Neuron64:173-187(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH SYNE2
15.

"SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice."
Lei K. , Zhang X. , Ding X. , Guo X. , Chen M. , Zhu B. , Xu T. , Zhuang Y. , Xu R. , Han M.
Proc. Natl. Acad. Sci. U.S.A.106:10207-10212(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
16.

"Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes."
Haque F. , Mazzeo D. , Patel J.T. , Smallwood D.T. , Ellis J.A. , Shanahan C.M. , Shackleton S.
J. Biol. Chem.285:3487-3498(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EMD
17.

"A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis."
Morimoto A. , Shibuya H. , Zhu X. , Kim J. , Ishiguro K. , Han M. , Watanabe Y.
J. Cell Biol.198:165-172(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CCDC155
18.

"The LINC complex is essential for hearing."
Horn H.F. , Brownstein Z. , Lenz D.R. , Shivatzki S. , Dror A.A. , Dagan-Rosenfeld O. , Friedman L.M. , Roux K.J. , Kozlov S. , Jeang K.T. , Frydman M. , Burke B. , Stewart C.L. , Avraham K.B.
J. Clin. Invest.123:740-750(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
19.

"The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis."
Shibuya H. , Ishiguro K.I. , Watanabe Y.
Nat. Cell Biol.16:145-156(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CCDC79

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