Sv2a ELISA Kit for Rat(Rattus norvegicus) | EIAab.comSv2a ELISA Kit for Rat(Rattus norvegicus)

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Sv2a (Gene name),

Synaptic vesicle glycoprotein 2A (Protein name ), SV2A_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Sv2a(Sv2);

Protein name:

Synaptic vesicle glycoprotein 2A(Synaptic vesicle protein 2;Synaptic vesicle protein 2A);

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2.

Function:

Receptor for the botulinium neurotoxin type A/BOTA.

Subcellular Location:

Cytoplasmic vesicle secretory vesicle synaptic vesicle membrane Multi-pass membrane protein Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas.

Protein Attributes:

Sequence length:

742

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

742:

ISIFTSFVGI | TKAAPILFAS | AALALGSSLA | LKLPETRGQV | LQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.11264

STRING:

10116.ENSRNOP00000028760

KEGG:

rno:117559

String:

Q02563

Pfam:

PF07690

Uniprot:

Q02563

FOR

ELISA Kit for Rat Synaptic vesicle protein 2

CLIA Kit for Rat Synaptic vesicle protein 2

Polyclonal Antibody for Rat Synaptic vesicle protein 2

Monoclonal Antibody for Rat Synaptic vesicle protein 2

Protein for Rat Synaptic vesicle protein 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The synaptic vesicle protein SV2 is a novel type of transmembrane transporter."
Feany M.B. , Lee S. , Edwards R.H. , Buckley K.M.
Cell70:861-867(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA];GLYCOSYLATION
2.

"Identification, characterization, and molecular cloning of a novel transporter-like protein localized to the central nervous system."
Gingrich J.A. , Andersen P.H. , Tiberi M. , el Mestikawy S. , Jorgensen P.N. , Fremeau R.T. Jr. , Caron M.G.
FEBS Lett.312:115-122(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 177-194 AND 372-381;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
3.

"SV2, a brain synaptic vesicle protein homologous to bacterial transporters."
Bajjalieh S.M. , Peterson K. , Shingal R. , Scheller R.H.
Science257:1271-1273(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 1-40
tissue: Brain.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
5.

"Isoform-specific, calcium-regulated interaction of the synaptic vesicle proteins SV2 and synaptotagmin."
Schivell A.E. , Batchelor R.H. , Bajjalieh S.M.
J. Biol. Chem.271:27770-27775(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYT1
6.

"SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family."
Janz R. , Suedhof T.C.
Neuroscience94:1279-1290(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
7.

"AP-2 recruitment to synaptotagmin stimulated by tyrosine-based endocytic motifs."
Haucke V. , De Camilli P.
Science285:1268-1271(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AP-2
8.

"Phosphorylation of synaptic vesicle protein 2 modulates binding to synaptotagmin."
Pyle R.A. , Schivell A.E. , Hidaka H. , Bajjalieh S.M.
J. Biol. Chem.275:17195-17200(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY CK1;INTERACTION WITH SYT1
9.

"The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam."
Lynch B.A. , Lambeng N. , Nocka K. , Kensel-Hammes P. , Bajjalieh S.M. , Matagne A. , Fuks B.
Proc. Natl. Acad. Sci. U.S.A.101:9861-9866(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION AS BINDING-SITE FOR ANTIEPILEPTIC DRUG LEVETIRACETAM
10.

"SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment."
Iezzi M. , Theander S. , Janz R. , Loze C. , Wollheim C.B.
J. Cell Sci.118:5647-5660(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
11.

"SV2A and SV2C contain a unique synaptotagmin-binding site."
Schivell A.E. , Mochida S. , Kensel-Hammes P. , Custer K.L. , Bajjalieh S.M.
Mol. Cell. Neurosci.29:56-64(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SYT1
12.

"SV2 is the protein receptor for botulinum neurotoxin A."
Dong M. , Yeh F. , Tepp W.H. , Dean C. , Johnson E.A. , Janz R. , Chapman E.R.
Science312:592-596(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A BOTA RECEPTOR

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