TNC ELISA Kit for Human(Homo sapiens) | EIAab.comTNC ELISA Kit for Human(Homo sapiens)

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Index > Protein center > TNC(Gene name) > Human

TNC (Gene name),

Tenascin (Protein name ), TENA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

TNC(HXB);

Protein name:

Tenascin(TN);

Alternative:

GMEM;Cytotactin;Glioma-associated-extracellular matrix antigen;GP 150-225;JI;Hexabrachion;Neuronectin;Myotendinous antigen;Tenascin-C(TN-C);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.

Function:

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.

Subcellular Location:

Secreted extracellular space extracellular matrix

Protein Attributes:

Sequence length:

2201

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3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF07974

KEGG:

hsa:3371

STRING:

9606.ENSP00000265131

String:

P24821

MIM:

187380

SMR:

P24821

UniGene:

Hs.143250

Uniprot:

P24821

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ELISA Kit for Human TN

Cat.:

E1975h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human TN

Cat.:

E1975m

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Manual:

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96T

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ELISA Kit for Human TN

Cat.:

E1975p

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Manual:

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Packing:

96T

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ELISA Kit for Human TN

Cat.:

E1975c

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Packing:

96T

CLIA Kit for Human TN

Cat.:

U1975m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human TN

Cat.:

U1975c

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MSDS:

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Packing:

96T

CLIA Kit for Human TN

Cat.:

U1975h

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Manual:

Looking for manual.

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Packing:

96T

Range:

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CLIA Kit for Human TN

Cat.:

U1975p

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human TN

Cat.:

P1975Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human TN

Cat.:

P1975Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human TN

Monoclonal Antibody for Human TN

Protein for Human TN

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"Tenascin-C produced by oxidized LDL-stimulated macrophages increases foam cell formation through Toll-like receptor-4"

R Liu, Y He, B Li, et al.

From:Molecules and cells

References

1.

"The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats."
Nies D.E. , Hemesath T.J. , Kim J.H. , Gulcher J.R. , Stefansson K.
J. Biol. Chem.266:2818-2823(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-539; LEU-1677 AND GLN-2008
2.

"Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies."
Siri A. , Carnemolla B. , Saginati M. , Leprini A. , Casari G. , Baralle F. , Zardi L.
Nucleic Acids Res.19:525-531(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 4 AND 5);PROTEIN SEQUENCE OF 23-32;VARIANTS ARG-680 AND GLN-2008
tissue: Fetal brain.
tissue: Melanoma.
3.

"Structure of the human hexabrachion (tenascin) gene."
Gulcher J.R. , Nies D.E. , Alexakos M.J. , Ravikant N.A. , Sturgill M.E. , Marton L.S. , Stefansson K.
Proc. Natl. Acad. Sci. U.S.A.88:9438-9442(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-539; LEU-1677 AND GLN-2008
4.

"Human tenascin gene. Structure of the 5'-region, identification, and characterization of the transcription regulatory sequences."
Gherzi R. , Carnemolla B. , Siri A. , Ponassi M. , Balza E. , Zardi L.
J. Biol. Chem.270:3429-3434(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS LEU-1677 AND GLN-2008
5.

"DNA sequence and analysis of human chromosome 9."
Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes."
Glumoff V. , Savontaus M. , Vehanen J. , Vuorio E.
Biochim. Biophys. Acta1219:613-622(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-125 (ISOFORMS 1/2/3/4/5/6)
tissue: Fetal cartilage.
7.

"An alternatively spliced region of the human hexabrachion contains a repeat of potential N-glycosylation sites."
Gulcher J.R. , Nies D.E. , Marton L.S. , Stefansson K.
Proc. Natl. Acad. Sci. U.S.A.86:1588-1592(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 431-2055 (ISOFORMS 1 AND 6);VARIANTS ARG-539; LEU-1677 AND GLN-2008
tissue: Glioblastoma.
8.

"Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules."
Burg M.A. , Tillet E. , Timpl R. , Stallcup W.B.
J. Biol. Chem.271:26110-26116(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CSPG4
9.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1809
tissue: Plasma.
10.

"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
Picariello G. , Ferranti P. , Mamone G. , Roepstorff P. , Addeo F.
Proteomics8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-184; ASN-1079; ASN-1093; ASN-1261; ASN-1301; ASN-1485 AND ASN-2162
tissue: Milk.
11.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1018; ASN-1034; ASN-1184; ASN-1275; ASN-1301; ASN-1366 AND ASN-1485
tissue: Liver.
12.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein."
Leahy D.J. , Hendrickson W.A. , Aukhil I. , Erickson H.P.
Science258:987-991(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF FIBRONECTIN TYPE-III 3
14.

"Exome sequencing and linkage analysis identified tenascin-C (TNC) as a novel causative gene in nonsyndromic hearing loss."
Zhao Y. , Zhao F. , Zong L. , Zhang P. , Guan L. , Zhang J. , Wang D. , Wang J. , Chai W. , Lan L. , Li Q. , Han B. , Yang L. , Jin X. , Yang W. , Hu X. , Wang X. , Li N. , more...
PLoS ONE8:E69549-E69549(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS DFNA56 MET-1773 AND SER-1796

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