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Index > Protein center > U2af2(Gene name) > Mouse
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  • U2af2 (Gene name),
  • Splicing factor U2AF 65 kDa subunit (Protein name ),  U2AF2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    U2af2(U2af65);
    Protein name:
    Splicing factor U2AF 65 kDa subunit;
    Alternative:
    U2 snRNP auxiliary factor large subunit;U2 auxiliary factor 65 kDa subunit;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterodimer with U2AF1. Binds unphosphorylated SF1. Interacts with SCAF11. Interacts with ZRSR2/U2AF1-RS2 (By similarity). Interacts with U2AF1L4.
    Function:
    Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    475
    Sequence:
    50:
    MSDFDEFERQ | LNENKQERDK | ENRHRKRSHS | RSRSRDRKRR | SRSRDRRNRD | 
    100:
    QRSASRDRRR | RSKPLTRGAK | EEHGGLIRSP | RHEKKKKVRK | YWDVPPPGFE | 
    150:
    HITPMQYKAM | QAAGQIPATA | LLPTMTPDGL | AVTPTPVPVV | GSQMTRQARR | 
    200:
    LYVGNIPFGI | TEEAMMDFFN | AQMRLGGLTQ | APGNPVLAVQ | INQDKNFAFL | 
    250:
    EFRSVDETTQ | AMAFDGIIFQ | GQSLKIRRPH | DYQPLPGMSE | NPSVYVPGVV | 
    300:
    STVVPDSAHK | LFIGGLPNYL | NDDQVKELLT | SFGPLKAFNL | VKDSATGLSK | 
    350:
    GYAFCEYVDI | NVTDQAIAGL | NGMQLGDKKL | LVQRASVGAK | NATLVSLPST | 
    400:
    INQTPVTLQV | PGLMSSQVQM | GGHPTEVLCL | MNMVLPEELL | DDEEYEEIVE | 
    450:
    DVRDECSKYG | LVKSIEIPRP | VDGVEVPGCG | KIFVEFTSVF | DCQKAMQGLT | 
    475:
    GRKFANRVVV | TKYCDPDSYH | RRDFW
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Splicing factor U2AF 65 kDa subunit
    ELISA Kit for Mouse Splicing factor U2AF 65 kDa subunit
    CLIA Kit for Mouse Splicing factor U2AF 65 kDa subunit
    CLIA Kit for Mouse Splicing factor U2AF 65 kDa subunit
    Polyclonal Antibody for Mouse Splicing factor U2AF 65 kDa subunit
    Polyclonal Antibody for Mouse Splicing factor U2AF 65 kDa subunit
    Monoclonal Antibody for Mouse Splicing factor U2AF 65 kDa subunit
    Monoclonal Antibody for Mouse Splicing factor U2AF 65 kDa subunit
    Protein for Mouse Splicing factor U2AF 65 kDa subunit
    Protein for Mouse Splicing factor U2AF 65 kDa subunit

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Cloning and sequencing of the murine homologue of the human splicing factor U2AF65."
      Sailer A. , Macdonald N.J. , Weissmann C.
      Nucleic Acids Res.20:2374-2374(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: SL/AM.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
    3. 3.
      "Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing."
      Heyd F. , ten Dam G. , Moeroey T.
      Nat. Immunol.7:859-867(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH U2AF1L4
    4. 4.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-70;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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