Gene name:
U2af2 (U2af65) ;
Protein name:
Splicing factor U2AF 65 kDa subunit ;
Alternative:
U2 snRNP auxiliary factor large subunit ;U2 auxiliary factor 65 kDa subunit ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Heterodimer with U2AF1. Binds unphosphorylated SF1. Interacts with SCAF11. Interacts with ZRSR2/U2AF1-RS2 (By similarity). Interacts with U2AF1L4.
Function:
Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MSDFDEFERQ | LNENKQERDK | ENRHRKRSHS | RSRSRDRKRR | SRSRDRRNRD |
100:
QRSASRDRRR | RSKPLTRGAK | EEHGGLIRSP | RHEKKKKVRK | YWDVPPPGFE |
150:
HITPMQYKAM | QAAGQIPATA | LLPTMTPDGL | AVTPTPVPVV | GSQMTRQARR |
200:
LYVGNIPFGI | TEEAMMDFFN | AQMRLGGLTQ | APGNPVLAVQ | INQDKNFAFL |
250:
EFRSVDETTQ | AMAFDGIIFQ | GQSLKIRRPH | DYQPLPGMSE | NPSVYVPGVV |
300:
STVVPDSAHK | LFIGGLPNYL | NDDQVKELLT | SFGPLKAFNL | VKDSATGLSK |
350:
GYAFCEYVDI | NVTDQAIAGL | NGMQLGDKKL | LVQRASVGAK | NATLVSLPST |
400:
INQTPVTLQV | PGLMSSQVQM | GGHPTEVLCL | MNMVLPEELL | DDEEYEEIVE |
450:
DVRDECSKYG | LVKSIEIPRP | VDGVEVPGCG | KIFVEFTSVF | DCQKAMQGLT |
475:
GRKFANRVVV | TKYCDPDSYH | RRDFW
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse Splicing factor U2AF 65 kDa subunit
ELISA Kit for Mouse Splicing factor U2AF 65 kDa subunit
CLIA Kit for Mouse Splicing factor U2AF 65 kDa subunit
CLIA Kit for Mouse Splicing factor U2AF 65 kDa subunit
Polyclonal Antibody for Mouse Splicing factor U2AF 65 kDa subunit
Polyclonal Antibody for Mouse Splicing factor U2AF 65 kDa subunit
Monoclonal Antibody for Mouse Splicing factor U2AF 65 kDa subunit
Monoclonal Antibody for Mouse Splicing factor U2AF 65 kDa subunit
Protein for Mouse Splicing factor U2AF 65 kDa subunit
Protein for Mouse Splicing factor U2AF 65 kDa subunit
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
SL/AM .
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH U2AF1L4
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-70;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .