Gene name:
Snrnp200 (Kiaa0788) ;
Protein name:
U5 small nuclear ribonucleoprotein 200 kDa helicase ;
Alternative:
U5 snRNP-specific 200 kDa protein (U5-200KD) ;BRR2 homolog ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of a core complex containing at least PRPF8, SNRNP200, EFTUD2 and SNRNP40. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Identified in the spliceosome C complex.
Function:
RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MADVTARSLQ | YEYKANSNLV | LQADRSLIDR | TRRDEPTGEV | LSLVGKLEGT |
100:
RMGDKAQRTK | PQMQEERRAK | RRKRDEDRHD | MNKMKGYTLL | SEGIDEMVGI |
150:
IYKPKTKETR | ETYEVLLSFI | QAALGDQPRD | ILCGAADEVL | AVLKNEKLRD |
200:
KERRREIDLL | LGQTDDTRYH | VLVNLGKKIT | DYGGDKEIQN | MDDNIDETYG |
250:
VNVQFESDEE | EGDEDVYGEV | REEASDDDME | GDEAVVRCTL | SANLVASGEL |
300:
MSSKKKDLHP | RDIDAFWLQR | QLSRFYDDAI | VSQKKADEVL | EILKTASDDR |
350:
ECENQLVLLL | GFNTFDFIKV | LRQHRMMILY | CTLLASAQSE | PEKERIVGKM |
400:
EADPELSKFL | YQLHETEKED | LIREERSRRE | RVRQSRMDTD | LETMDLDQGG |
450:
EALAPRQVLD | LEDLVFTQGS | HFMANKRCQL | PDGSFRRQRK | GYEEVHVPAL |
500:
KPKPFGSEEQ | LLPVEKLPKY | AQAGFEGFKT | LNRIQSKLYR | AALETDENLL |
550:
LCAPTGAGKT | NVALMCMLRE | IGKHINMDGT | INVDDFKIIY | IAPMRSLVQE |
600:
MVGSFGKRLA | TYGITVAELT | GDHQLCKEEI | SATQIIVCTP | EKWDIITRKG |
650:
GERTYTQLVR | LIVLDEIHLL | HDDRGPVLEA | LVARAIRNIE | MTQEDVRLIG |
700:
LSATLPNYED | VATFLRVDPA | KGLFYFDNSF | RPVPLEQTYV | GITEKKAIKR |
750:
FQIMNEIVYE | KIMEHAGKNQ | VLVFVHSRKE | TGKTARAIRD | MCLEKDTLGL |
800:
FLREGSASTE | VLRTEAEQCK | NLELKDLLPY | GFAIHHAGMT | RVDRTLVEDL |
850:
FADKHIQVLV | STATLAWGVN | LPAHTVIIKG | TQVYSPEKGR | WTELGALDIL |
900:
QMLGRAGRPQ | YDTKGEGILI | TSHGELQYYL | SLLNQQLPIE | SQMVSKLPDM |
950:
LNAEIVLGNV | QNAKDAVNWL | GYAYLYIRML | RSPTLYGISH | DDLKGDPLLD |
1000:
QRRLDLVHTA | ALMLDKNNLV | KYDKKTGNFQ | VTELGRIASH | YYITNDTVQT |
1050:
YNQLLKPTLS | EIELFRVFSL | SSEFKNITVR | EEEKLELQKL | LERVPIPVKE |
1100:
SIEEPSAKIN | VLLQAFISQL | KLEGFALMAD | MVYVTQSAGR | LMRAIFEIVL |
1150:
NRGWAQLTDK | TLNLCKMIDK | RMWQSMCPLR | QFRKLPEEVV | KKIEKKNFPF |
1200:
ERLYDLNHNE | IGELIRMPKM | GKTIHKYVHL | FPKLELSVHL | QPITRSTLKV |
1250:
ELTITPDFQW | DEKVHGSSEA | FWILVEDVDS | EVILHHEYFL | LKAKYAQDEH |
1300:
LITFFVPVFE | PLPPQYFIRV | VSDRWLSCET | QLPVSFRHLI | LPEKYPPPTE |
1350:
LLDLQPLPVS | ALRNSAFESL | YQDKFPFFNP | IQTQVFNTVY | NSDDNVFVGA |
1400:
PTGSGKTICA | EFAILRMLLQ | NSEGRCVYIT | PMEALAEQVY | MDWYEKFQDR |
1450:
LNKKVVLLTG | ETSTDLKLLG | KGNIIISTPE | KWDILSRRWK | QRKNVQNINL |
1500:
FVVDEVHLIG | GENGPVLEVI | CSRMRYISSQ | IERPIRIVAL | SSSLSNAKDV |
1550:
AHWLGCSATS | TFNFHPNVRP | VPLELHIQGF | NISHTQTRLL | SMAKPVYHAI |
1600:
TKHSPKKPVI | VFVPSRKQTR | LTAIDILTTC | AADIQRQRFL | HCTEKDLIPY |
1650:
LEKLSDSTLK | ETLLNGVGYL | HEGLSPMERR | LVEQLFSSGA | IQVVVASRSL |
1700:
CWGMNVAAHL | VIIMDTQYYN | GKIHAYVDYP | IYDVLQMVGH | ANRPLQDDEG |
1750:
RCVIMCQGSK | KDFFKKFLYE | PLPVESHLDH | CMHDHFNAEI | VTKTIENKQD |
1800:
AVDYLTWTFL | YRRMTQNPNY | YNLQGISHRH | LSDHLSELVE | QTLSDLEQSK |
1850:
CISIEDEMDV | APLNLGMIAA | YYYINYTTIE | LFSMSLNAKT | KVRGLIEIIS |
1900:
NAAEYENIPI | RHHEDNLLRQ | LAQKVPHKLN | NPKFNDPHVK | TNLLLQAHLS |
1950:
RMQLSAELQS | DTEEILSKAI | RLIQACVDVL | SSNGWLSPAL | AAMELAQMVT |
2000:
QAMWSKDSYL | KQLPHFTSEH | IKRCTDKGVE | SVFDIMEMED | EERNALLQLT |
2050:
DSQIADVARF | CNRYPNIELS | YEVVDKDSIR | SGGPVVVLVQ | LEREEEVTGP |
2100:
VIAPLFPQKR | EEGWWVVIGD | AKSNSLISIK | RLTLQQKAKV | KLDFVAPATG |
2136:
GHNYTLYFMS | DAYMGCDQEY | KFSVDVKEAE | TDSDSD
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Mouse U5 small nuclear ribonucleoprotein 200 kDa helicase
ELISA Kit for Mouse U5 small nuclear ribonucleoprotein 200 kDa helicase
ELISA Kit for Mouse U5 small nuclear ribonucleoprotein 200 kDa helicase
CLIA Kit for Mouse U5 small nuclear ribonucleoprotein 200 kDa helicase
CLIA Kit for Mouse U5 small nuclear ribonucleoprotein 200 kDa helicase
CLIA Kit for Mouse U5 small nuclear ribonucleoprotein 200 kDa helicase
Polyclonal Antibody for Mouse U5 small nuclear ribonucleoprotein 200 kDa helicase
Polyclonal Antibody for Mouse U5 small nuclear ribonucleoprotein 200 kDa helicase
Polyclonal Antibody for Mouse U5 small nuclear ribonucleoprotein 200 kDa helicase
Monoclonal Antibody for Mouse U5 small nuclear ribonucleoprotein 200 kDa helicase
Monoclonal Antibody for Mouse U5 small nuclear ribonucleoprotein 200 kDa helicase
Monoclonal Antibody for Mouse U5 small nuclear ribonucleoprotein 200 kDa helicase
Protein for Mouse U5 small nuclear ribonucleoprotein 200 kDa helicase
Protein for Mouse U5 small nuclear ribonucleoprotein 200 kDa helicase
Protein for Mouse U5 small nuclear ribonucleoprotein 200 kDa helicase
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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PubMed ]
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Europe PMC ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
tissue :
Brain .
3.
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Europe PMC ]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 228-2136
tissue :
Embryonic tail .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1765;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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tissue :
Liver .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]