Protein name:
Ubiquitin-conjugating enzyme E2 B ;
Alternative:
Ubiquitin carrier protein B ;RAD6 homolog B (HR6B;hHR6B) ;Ubiquitin-protein ligase B ;Ubiquitin-conjugating enzyme E2-17 kDa ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with RAD18, UBR2 and WAC.
Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.
Subcellular Location:
Cell membrane
Nucleus
In peripheral neurons, expressed both at the plasma membrane and in nuclei.
Protein Attributes:
50:
MSTPARRRLM | RDFKRLQEDP | PVGVSGAPSE | NNIMQWNAVI | FGPEGTPFED |
100:
GTFKLVIEFS | EEYPNKPPTV | RFLSKMFHPN | VYADGSICLD | ILQNRWSPTY |
150:
DVSSILTSIQ | SLLDEPNPNS | PANSQAAQLY | QENKREYEKR | VSAIVEQSWN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Bovine
Mouse
Rabbit
ELISA Kit for Human Ubiquitin-conjugating enzyme E2 B
ELISA Kit for Human Ubiquitin-conjugating enzyme E2 B
ELISA Kit for Human Ubiquitin-conjugating enzyme E2 B
ELISA Kit for Human Ubiquitin-conjugating enzyme E2 B
ELISA Kit for Human Ubiquitin-conjugating enzyme E2 B
CLIA Kit for Human Ubiquitin-conjugating enzyme E2 B
CLIA Kit for Human Ubiquitin-conjugating enzyme E2 B
CLIA Kit for Human Ubiquitin-conjugating enzyme E2 B
CLIA Kit for Human Ubiquitin-conjugating enzyme E2 B
CLIA Kit for Human Ubiquitin-conjugating enzyme E2 B
Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
Protein for Human Ubiquitin-conjugating enzyme E2 B
Protein for Human Ubiquitin-conjugating enzyme E2 B
Protein for Human Ubiquitin-conjugating enzyme E2 B
Protein for Human Ubiquitin-conjugating enzyme E2 B
Protein for Human Ubiquitin-conjugating enzyme E2 B
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
tissue :
Placenta .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
4.
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
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Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
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,
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,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
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,
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,
Nusskern D.R.
,
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,
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,
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,
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,
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,
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,
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,
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,
Eichler E.E.
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,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Bone marrow .
tissue :
Brain .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RAD18
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH WAC
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR