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Index > Protein center > VPS26A(Gene name) > Human
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  • VPS26A (Gene name),
  • Vacuolar protein sorting-associated protein 26A (Protein name ),  VP26A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    VPS26A(VPS26);
    Protein name:
    Vacuolar protein sorting-associated protein 26A;
    Alternative:
    Vesicle protein sorting 26A(hVPS26);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts directly with VPS35. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with ECM29.
    Function:
    Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA).
    Subcellular Location:
    Cytoplasm Endosome membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    327
    Sequence:
    50:
    MSFLGGFFGP | ICEIDIVLND | GETRKMAEMK | TEDGKVEKHY | LFYDGESVSG | 
    100:
    KVNLAFKQPG | KRLEHQGIRI | EFVGQIELFN | DKSNTHEFVN | LVKELALPGE | 
    150:
    LTQSRSYDFE | FMQVEKPYES | YIGANVRLRY | FLKVTIVRRL | TDLVKEYDLI | 
    200:
    VHQLATYPDV | NNSIKMEVGI | EDCLHIEFEY | NKSKYHLKDV | IVGKIYFLLV | 
    250:
    RIKIQHMELQ | LIKKEITGIG | PSTTTETETI | AKYEIMDGAP | VKGESIPIRL | 
    300:
    FLAGYDPTPT | MRDVNKKFSV | RYFLNLVLVD | EEDRRYFKQQ | EIILWRKAPE | 
    327:
    KLRKQRTNFH | QRFESPESQA | SAEQPEM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    MIM:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Vacuolar protein sorting-associated protein 26A
    ELISA Kit for Human Vacuolar protein sorting-associated protein 26A
    ELISA Kit for Human Vacuolar protein sorting-associated protein 26A
    ELISA Kit for Human Vacuolar protein sorting-associated protein 26A
    CLIA Kit for Human Vacuolar protein sorting-associated protein 26A
    CLIA Kit for Human Vacuolar protein sorting-associated protein 26A
    CLIA Kit for Human Vacuolar protein sorting-associated protein 26A
    CLIA Kit for Human Vacuolar protein sorting-associated protein 26A
    Polyclonal Antibody for Human Vacuolar protein sorting-associated protein 26A
    Polyclonal Antibody for Human Vacuolar protein sorting-associated protein 26A
    Polyclonal Antibody for Human Vacuolar protein sorting-associated protein 26A
    Polyclonal Antibody for Human Vacuolar protein sorting-associated protein 26A
    Monoclonal Antibody for Human Vacuolar protein sorting-associated protein 26A
    Monoclonal Antibody for Human Vacuolar protein sorting-associated protein 26A
    Monoclonal Antibody for Human Vacuolar protein sorting-associated protein 26A
    Monoclonal Antibody for Human Vacuolar protein sorting-associated protein 26A
    Protein for Human Vacuolar protein sorting-associated protein 26A
    Protein for Human Vacuolar protein sorting-associated protein 26A
    Protein for Human Vacuolar protein sorting-associated protein 26A
    Protein for Human Vacuolar protein sorting-associated protein 26A

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes."
      Renfrew Haft C. , de la Luz Sierra M. , Bafford R. , Lesniak M.A. , Barr V.A. , Taylor S.I.
      Mol. Biol. Cell11:4105-4116(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH VPS29; VPS35; SNX1 AND SNX2;SUBUNIT
      tissue: Colon.
    2. 2.
      "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
      Mao M. , Fu G. , Wu J.-S. , Zhang Q.-H. , Zhou J. , Kan L.-X. , Huang Q.-H. , He K.-L. , Gu B.-W. , Han Z.-G. , Shen Y. , Gu J. , Yu Y.-P. , Xu S.-H. , Wang Y.-X. , Chen S.-J. , Chen Z.
      Proc. Natl. Acad. Sci. U.S.A.95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Umbilical cord blood.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Tongue.
    4. 4.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-249 (ISOFORM 2)
      tissue: Brain.
      tissue: Embryonic testis carcinoma.
    7. 7.
      "Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer."
      Seaman M.N.J.
      J. Cell Biol.165:111-122(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor."
      Arighi C.N. , Hartnell L.M. , Aguilar R.C. , Haft C.R. , Bonifacino J.S.
      J. Cell Biol.165:123-133(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    9. 9.
      "The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor."
      Verges M. , Luton F. , Gruber C. , Tiemann F. , Reinders L.G. , Huang L. , Burlingame A.L. , Haft C.R. , Mostov K.E.
      Nat. Cell Biol.6:763-769(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "Model-guided microarray implicates the retromer complex in Alzheimer's disease."
      Small S.A. , Kent K. , Pierce A. , Leung C. , Kang M.S. , Okada H. , Honig L. , Vonsattel J.-P. , Kim T.-W.
      Ann. Neurol.58:909-919(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH VPS35
    12. 12.
      "An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins."
      Gullapalli A. , Wolfe B.L. , Griffin C.T. , Magnuson T. , Trejo J.
      Mol. Biol. Cell17:1228-1238(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      "No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease."
      Riemenschneider M. , Schoepfer-Wendels A. , Friedrich P. , Konta L. , Laws S.M. , Mueller J.C. , Kurz A. , Forstl H.
      Neurobiol. Aging28:883-884(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    15. 15.
      "EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval."
      Gokool S. , Tattersall D. , Seaman M.N.
      Traffic8:1873-1886(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EHD1
    16. 16.
      "The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network."
      Wassmer T. , Attar N. , Harterink M. , van Weering J.R. , Traer C.J. , Oakley J. , Goud B. , Stephens D.J. , Verkade P. , Korswagen H.C. , Cullen P.J.
      Dev. Cell17:110-122(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNX1; SNX2; SNX5 AND SNX6
    17. 17.
      "Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5."
      Seaman M.N. , Harbour M.E. , Tattersall D. , Read E. , Bright N.
      J. Cell Sci.122:2371-2382(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAB7A
    18. 18.
      "A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components."
      Gorbea C. , Pratt G. , Ustrell V. , Bell R. , Sahasrabudhe S. , Hughes R.E. , Rechsteiner M.
      J. Biol. Chem.285:31616-31633(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH ECM29
    19. 19.
      "The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics."
      Harbour M.E. , Breusegem S.Y. , Antrobus R. , Freeman C. , Reid E. , Seaman M.N.
      J. Cell Sci.123:3703-3717(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH KIAA0196
    20. 20.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 22.
      "SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors."
      Temkin P. , Lauffer B. , Jager S. , Cimermancic P. , Krogan N.J. , von Zastrow M.
      Nat. Cell Biol.13:715-721(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    23. 23.
      "A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion."
      Harterink M. , Port F. , Lorenowicz M.J. , McGough I.J. , Silhankova M. , Betist M.C. , van Weering J.R. , van Heesbeen R.G. , Middelkoop T.C. , Basler K. , Cullen P.J. , Korswagen H.C.
      Nat. Cell Biol.13:914-923(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNX3;FUNCTION OF THE SNX3-RETROMER
    24. 24.
      "Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35."
      Harbour M.E. , Breusegem S.Y. , Seaman M.N.
      Biochem. J.442:209-220(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    25. 25.
      "Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing."
      Fjorback A.W. , Seaman M. , Gustafsen C. , Mehmedbasic A. , Gokool S. , Wu C. , Militz D. , Schmidt V. , Madsen P. , Nyengaard J.R. , Willnow T.E. , Christensen E.I. , Mobley W.B. , Nykjaer A. , Andersen O.M.
      J. Neurosci.32:1467-1480(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SORL1
    26. 26.
      "A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport."
      Steinberg F. , Gallon M. , Winfield M. , Thomas E.C. , Bell A.J. , Heesom K.J. , Tavare J.M. , Cullen P.J.
      Nat. Cell Biol.15:461-471(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNX27;FUNCTION OF THE SNX27-RETROMER
    27. 27.
      "A mechanism for retromer endosomal coat complex assembly with cargo."
      Harrison M.S. , Hung C.S. , Liu T.T. , Christiano R. , Walther T.C. , Burd C.G.
      Proc. Natl. Acad. Sci. U.S.A.111:267-272(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAB7A
    28. 28.
      "The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain."
      Shi H. , Rojas R. , Bonifacino J.S. , Hurley J.H.
      Nat. Struct. Mol. Biol.13:540-548(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS);SUBCELLULAR LOCATION;INTERACTION WITH VPS35;MUTAGENESIS OF 236-ILE-MET-237
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