Gene name:
VPS26A (VPS26) ;
Protein name:
Vacuolar protein sorting-associated protein 26A ;
Alternative:
Vesicle protein sorting 26A (hVPS26) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts directly with VPS35. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with ECM29.
Function:
Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA).
Subcellular Location:
Cytoplasm
Endosome membrane
Peripheral membrane protein
Protein Attributes:
50:
MSFLGGFFGP | ICEIDIVLND | GETRKMAEMK | TEDGKVEKHY | LFYDGESVSG |
100:
KVNLAFKQPG | KRLEHQGIRI | EFVGQIELFN | DKSNTHEFVN | LVKELALPGE |
150:
LTQSRSYDFE | FMQVEKPYES | YIGANVRLRY | FLKVTIVRRL | TDLVKEYDLI |
200:
VHQLATYPDV | NNSIKMEVGI | EDCLHIEFEY | NKSKYHLKDV | IVGKIYFLLV |
250:
RIKIQHMELQ | LIKKEITGIG | PSTTTETETI | AKYEIMDGAP | VKGESIPIRL |
300:
FLAGYDPTPT | MRDVNKKFSV | RYFLNLVLVD | EEDRRYFKQQ | EIILWRKAPE |
327:
KLRKQRTNFH | QRFESPESQA | SAEQPEM
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
Bovine
ELISA Kit for Human Vacuolar protein sorting-associated protein 26A
ELISA Kit for Human Vacuolar protein sorting-associated protein 26A
ELISA Kit for Human Vacuolar protein sorting-associated protein 26A
ELISA Kit for Human Vacuolar protein sorting-associated protein 26A
CLIA Kit for Human Vacuolar protein sorting-associated protein 26A
CLIA Kit for Human Vacuolar protein sorting-associated protein 26A
CLIA Kit for Human Vacuolar protein sorting-associated protein 26A
CLIA Kit for Human Vacuolar protein sorting-associated protein 26A
Polyclonal Antibody for Human Vacuolar protein sorting-associated protein 26A
Polyclonal Antibody for Human Vacuolar protein sorting-associated protein 26A
Polyclonal Antibody for Human Vacuolar protein sorting-associated protein 26A
Polyclonal Antibody for Human Vacuolar protein sorting-associated protein 26A
Monoclonal Antibody for Human Vacuolar protein sorting-associated protein 26A
Monoclonal Antibody for Human Vacuolar protein sorting-associated protein 26A
Monoclonal Antibody for Human Vacuolar protein sorting-associated protein 26A
Monoclonal Antibody for Human Vacuolar protein sorting-associated protein 26A
Protein for Human Vacuolar protein sorting-associated protein 26A
Protein for Human Vacuolar protein sorting-associated protein 26A
Protein for Human Vacuolar protein sorting-associated protein 26A
Protein for Human Vacuolar protein sorting-associated protein 26A
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH VPS29; VPS35; SNX1 AND SNX2;SUBUNIT
tissue :
Colon .
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Umbilical cord blood .
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Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Tongue .
4.
"The DNA sequence and comparative analysis of human chromosome 10."
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[
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
Mural R.J.
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more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-249 (ISOFORM 2)
tissue :
Brain .
tissue :
Embryonic testis carcinoma .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;INTERACTION WITH VPS35
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH EHD1
16.
"The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network."
Wassmer T.
,
Attar N.
,
Harterink M.
,
van Weering J.R.
,
Traer C.J.
,
Oakley J.
,
Goud B.
,
Stephens D.J.
,
Verkade P.
,
Korswagen H.C.
,
Cullen P.J.
Dev. Cell17:110-122(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SNX1; SNX2; SNX5 AND SNX6
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RAB7A
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;INTERACTION WITH ECM29
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH KIAA0196
20.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
21.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.
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Cited for : FUNCTION
23.
"A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion."
Harterink M.
,
Port F.
,
Lorenowicz M.J.
,
McGough I.J.
,
Silhankova M.
,
Betist M.C.
,
van Weering J.R.
,
van Heesbeen R.G.
,
Middelkoop T.C.
,
Basler K.
,
Cullen P.J.
,
Korswagen H.C.
Nat. Cell Biol.13:914-923(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : INTERACTION WITH SNX3;FUNCTION OF THE SNX3-RETROMER
24.
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Cited for : FUNCTION
25.
"Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing."
Fjorback A.W.
,
Seaman M.
,
Gustafsen C.
,
Mehmedbasic A.
,
Gokool S.
,
Wu C.
,
Militz D.
,
Schmidt V.
,
Madsen P.
,
Nyengaard J.R.
,
Willnow T.E.
,
Christensen E.I.
,
Mobley W.B.
,
Nykjaer A.
,
Andersen O.M.
J. Neurosci.32:1467-1480(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : FUNCTION;INTERACTION WITH SORL1
26.
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Cited for : INTERACTION WITH SNX27;FUNCTION OF THE SNX27-RETROMER
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RAB7A
28.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS);SUBCELLULAR LOCATION;INTERACTION WITH VPS35;MUTAGENESIS OF 236-ILE-MET-237