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Index > Protein center > WNK2(Gene name) > Human
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  • WNK2 (Gene name),
  • Serine/threonine-protein kinase WNK2 (Protein name ),  WNK2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    WNK2(P/OKcl.13;KIAA1760;PRKWNK2;SDCCAG43);
    Protein name:
    Serine/threonine-protein kinase WNK2;
    Alternative:
    Protein kinase lysine-deficient 2;Antigen NY-CO-43;Serologically defined colon cancer antigen 43;Protein kinase with no lysine 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms a complex with the phosphorylated form of STK39.
    Function:
    Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
    Subcellular Location:
    Cytoplasm Cell membrane
    Protein Attributes:
    Sequence length:
    2297
    Sequence:
    50:
    MDGDGGRRDV | PGTLMEPGRG | AGPAGMAEPR | AKAARPGPQR | FLRRSVVESD | 
    100:
    QEEPPGLEAA | EAPGPQPPQP | LQRRVLLLCK | TRRLIAERAR | GRPAAPAPAA | 
    150:
    LVAQPGAPGA | PADAGPEPVG | TQEPGPDPIA | AAVETAPAPD | GGPREEAAAT | 
    200:
    VRKEDEGAAE | AKPEPGRTRR | DEPEEEEDDE | DDLKAVATSL | DGRFLKFDIE | 
    250:
    LGRGSFKTVY | KGLDTETWVE | VAWCELQDRK | LTKLERQRFK | EEAEMLKGLQ | 
    300:
    HPNIVRFYDF | WESSAKGKRC | IVLVTELMTS | GTLKTYLKRF | KVMKPKVLRS | 
    350:
    WCRQILKGLL | FLHTRTPPII | HRDLKCDNIF | ITGPTGSVKI | GDLGLATLKR | 
    400:
    ASFAKSVIGT | PEFMAPEMYE | EHYDESVDVY | AFGMCMLEMA | TSEYPYSECQ | 
    450:
    NAAQIYRKVT | CGIKPASFEK | VHDPEIKEII | GECICKNKEE | RYEIKDLLSH | 
    500:
    AFFAEDTGVR | VELAEEDHGR | KSTIALRLWV | EDPKKLKGKP | KDNGAIEFTF | 
    550:
    DLEKETPDEV | AQEMIESGFF | HESDVKIVAK | SIRDRVALIQ | WRRERIWPAL | 
    600:
    QPKEQQDVGS | PDKARGPPVP | LQVQVTYHAQ | AGQPGPPEPE | EPEADQHLLP | 
    650:
    PTLPTSATSL | ASDSTFDSGQ | GSTVYSDSQS | SQQSVMLGSL | ADAAPSPAQC | 
    700:
    VCSPPVSEGP | VLPQSLPSLG | AYQQPTAAPG | LPVGSVPAPA | CPPSLQQHFP | 
    750:
    DPAMSFAPVL | PPPSTPMPTG | PGQPAPPGQQ | PPPLAQPTPL | PQVLAPQPVV | 
    800:
    PLQPVPPHLP | PYLAPASQVG | APAQLKPLQM | PQAPLQPLAQ | VPPQMPPIPV | 
    850:
    VPPITPLAGI | DGLPPALPDL | PTATVPPVPP | PQYFSPAVIL | PSLAAPLPPA | 
    900:
    SPALPLQAVK | LPHPPGAPLA | MPCRTIVPNA | PATIPLLAVA | PPGVAALSIH | 
    950:
    SAVAQLPGQP | VYPAAFPQMA | PTDVPPSPHH | TVQNMRATPP | QPALPPQPTL | 
    1000:
    PPQPVLPPQP | TLPPQPVLPP | QPTRPPQPVL | PPQPMLPPQP | VLPPQPALPV | 
    1050:
    RPEPLQPHLP | EQAAPAATPG | SQILLGHPAP | YAVDVAAQVP | TVPVPPAAVL | 
    1100:
    SPPLPEVLLP | AAPELLPQFP | SSLATVSASV | QSVPTQTATL | LPPANPPLPG | 
    1150:
    GPGIASPCPT | VQLTVEPVQE | EQASQDKPPG | LPQSCESYGG | SDVTSGKELS | 
    1200:
    DSCEGAFGGG | RLEGRAARKH | HRRSTRARSR | QERASRPRLT | ILNVCNTGDK | 
    1250:
    MVECQLETHN | HKMVTFKFDL | DGDAPDEIAT | YMVEHDFILQ | AERETFIEQM | 
    1300:
    KDVMDKAEDM | LSEDTDADRG | SDPGTSPPHL | STCGLGTGEE | SRQSQANAPV | 
    1350:
    YQQNVLHTGK | RWFIICPVAE | HPAPEAPESS | PPLPLSSLPP | EASQGPCRGL | 
    1400:
    TLPCLPWRRA | ACGAVFLSLF | SAESAQSKQP | PDSAPYKDQL | SSKEQPSFLA | 
    1450:
    SQQLLSQAGP | SNPPGAPPAP | LAPSSPPVTA | LPQDGAAPAT | STMPEPASGT | 
    1500:
    ASQAGGPGTP | QGLTSELETS | QPLAETHEAP | LAVQPLVVGL | APCTPAPEAA | 
    1550:
    STRDASAPRE | PLPPPAPEPS | PHSGTPQPAL | GQPAPLLPAA | VGAVSLATSQ | 
    1600:
    LPSPPLGPTV | PPQPPSALES | DGEGPPPRVG | FVDSTIKSLD | EKLRTLLYQE | 
    1650:
    HVPTSSASAG | TPVEVGDRDF | TLEPLRGDQP | RSEVCGGDLA | LPPVPKEAVS | 
    1700:
    GRVQLPQPLV | EKSELAPTRG | AVMEQGTSSS | MTAESSPRSM | LGYDRDGRQV | 
    1750:
    ASDSHVVPSV | PQDVPAFVRP | ARVEPTDRDG | GEAGESSAEP | PPSDMGTVGG | 
    1800:
    QASHPQTLGA | RALGSPRKRP | EQQDVSSPAK | TVGRFSVVST | QDEWTLASPH | 
    1850:
    SLRYSAPPDV | YLDEAPSSPD | VKLAVRRAQT | ASSIEVGVGE | PVSSDSGDEG | 
    1900:
    PRARPPVQKQ | ASLPVSGSVA | GDFVKKATAF | LQRPSRAGSL | GPETPSRVGM | 
    1950:
    KVPTISVTSF | HSQSSYISSD | NDSELEDADI | KKELQSLREK | HLKEISELQS | 
    2000:
    QQKQEIEALY | RRLGKPLPPN | VGFFHTAPPT | GRRRKTSKSK | LKAGKLLNPL | 
    2050:
    VRQLKVVASS | TGHLADSSRG | PPAKDPAQAS | VGLTADSTGL | SGKAVQTQQP | 
    2100:
    CSVRASLSSD | ICSGLASDGG | GARGQGWTVY | HPTSERVTYK | SSSKPRARFL | 
    2150:
    SGPVSVSIWS | ALKRLCLGKE | HSSRSSTSSL | APGPEPGPQP | ALHVQAQVNN | 
    2200:
    SNNKKGTFTD | DLHKLVDEWT | SKTVGAAQLK | PTLNQLKQTQ | KLQDMEAQAG | 
    2250:
    WAAPGEARAM | TAPRAGVGMP | RLPPAPGPLS | TTVIPGAAPT | LSVPTPDGAL | 
    2297:
    GTARRNQVWF | GLRVPPTACC | GHSTQPRGGQ | RVGSKTASFA | ASDPVRS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    Pfam:
    UniGene:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Serine/threonine-protein kinase WNK2
    ELISA Kit for Human Serine/threonine-protein kinase WNK2
    CLIA Kit for Human Serine/threonine-protein kinase WNK2
    CLIA Kit for Human Serine/threonine-protein kinase WNK2
    Polyclonal Antibody for Human Serine/threonine-protein kinase WNK2
    Polyclonal Antibody for Human Serine/threonine-protein kinase WNK2
    Monoclonal Antibody for Human Serine/threonine-protein kinase WNK2
    Monoclonal Antibody for Human Serine/threonine-protein kinase WNK2
    Protein for Human Serine/threonine-protein kinase WNK2
    Protein for Human Serine/threonine-protein kinase WNK2

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms."
      Verissimo F. , Jordan P.
      Oncogene20:5562-5569(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;CHROMOSOMAL LOCATION
      tissue: Colon epithelium.
    2. 2.
      Jordan P.
      Submitted (2005-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "Molecular basis of T cell-mediated recognition of pancreatic cancer cells."
      Ito M. , Shichijo S. , Tsuda N. , Ochi M. , Harashima N. , Saito N. , Itoh K.
      Cancer Res.61:2038-2046(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-845 (ISOFORM 3)
      tissue: Pancreatic cancer.
    5. 5.
      "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Hattori A. , Kondo Y. , Okumura K. , Ohara O.
      DNA Res.7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-2297 (ISOFORM 2)
      tissue: Brain.
    6. 6.
      Ohara O. , Nagase T. , Kikuno R.
      Submitted (2000-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1609-2297 (ISOFORM 4)
      tissue: Lung.
    8. 8.
      "Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2."
      Moniz S. , Verissimo F. , Matos P. , Brazao R. , Silva E. , Kotelevets L. , Kotevelets L. , Chastre E. , Gespach C. , Jordan P.
      Oncogene26:6071-6081(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;AUTOPHOSPHORYLATION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    10. 10.
      "WNK2 modulates MEK1 activity through the Rho GTPase pathway."
      Moniz S. , Matos P. , Jordan P.
      Cell. Signal.20:1762-1768(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1817 AND SER-1818;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1817 AND SER-1818;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    14. 14.
      "WNK2 is a novel regulator of essential neuronal cation-chloride cotransporters."
      Rinehart J. , Vazquez N. , Kahle K.T. , Hodson C.A. , Ring A.M. , Gulcicek E.E. , Louvi A. , Bobadilla N.A. , Gamba G. , Lifton R.P.
      J. Biol. Chem.286:30171-30180(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;PHOSPHORYLATION AT SER-45; SER-560; SER-1150; SER-1262; SER-1588; SER-1685; SER-1736; SER-1817; SER-1818; SER-1862 AND SER-2067
    15. 15.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1862;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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