Protein name:
Nuclear factor NF-kappa-B p105 subunit ;
Alternative:
EBP-1 ;DNA-binding factor KBF1 ;Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-p50 complex. Homodimer; component of the NF-kappa-B p50-p50 complex. Component of the NF-kappa-B p105-p50 complex. Component of the NF-kappa-B p50-c-Rel complex. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity. Interacts with DSIPI; this interaction prevents nuclear translocation and DNA-binding. Interacts with SPAG9 and UNC5CL. NFKB1/p105 interacts with CFLAR; the interaction inhibits p105 processing into p50. NFKB1/p105 forms a ternary complex with MAP3K8 and TNIP2. Interacts with GSK3B; the interaction prevents processing of p105 to p50. NFKB1/p50 interacts with NFKBIE. NFKB1/p50 interacts with NFKBIZ. Nuclear factor NF-kappa-B p50 subunit interacts with NFKBID (By similarity). Directly interacts with MEN1.
Function:
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. Plays a role in the regulation of apoptosis. Isoform 5, isoform 6 and isoform 7 act as inhibitors of transactivation of p50 NF-kappa-B subunit, probably by sequestering it in the cytoplasm. Isoform 3 (p98) (but not p84 or p105) acts as a transactivator of NF-kappa-B-regulated gene expression. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.
Subcellular Location:
Nucleus
Cytoplasm
Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
Protein Attributes:
50:
REILNPPEKE | TQGEGPSLFM | ASTKTEAIAP | ASTMEDKEED | VGFQDNLFLE |
100:
KALQLAKRHA | NALFDYAVTG | DVKMLLAVQR | HLTAVQDENG | DSVLHLAIIH |
150:
LHAQLVRDLL | EVTSGSISDD | IINMRNDLYQ | TPLHLAVITK | QEDVVEDLLR |
200:
VGADLSLLDR | WGNSVLHLAA | KEGHDKILGV | LLKNSKAALL | INHPNGEGLN |
250:
AIHIAVMSNS | LSCLQLLVAA | GAEVNAQEQK | SGRTALHLAV | EYDNISLAGC |
300:
LLLEGDALVD | STTYDGTTPL | HIAAGRGSTR | LAALLKAAGA | DPLVENFEPL |
350:
YDLDDSWEKA | GEDEGVVPGT | TPLDMAANWQ | VFDILNGKPY | EPVFTSDDIL |
400:
PQGDIKQLTE | DTRLQLCKLL | EIPDPDKNWA | TLAQKLGLGI | LNNAFRLSPA |
450:
PSKTLMDNYE | VSGGTIKELV | EALRQMGYTE | AIEVIQAAFR | TPETTASSPV |
500:
TTAQAHLLPL | SSSSTRQHID | ELRDNDSVCD | SGVETSFRKL | SFSESLTGDG |
522:
PLLSLNKMPH | NYGQDGPIEG | KI
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Dog
Chicken
Mouse
ELISA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
ELISA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
ELISA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
ELISA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
ELISA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
CLIA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
CLIA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
CLIA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
CLIA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
CLIA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
Polyclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
Polyclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
Polyclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
Polyclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
Polyclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
Monoclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
Monoclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
Monoclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
Monoclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
Monoclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
Protein for Rat Nuclear factor NF-kappa-B p105 subunit
Protein for Rat Nuclear factor NF-kappa-B p105 subunit
Protein for Rat Nuclear factor NF-kappa-B p105 subunit
Protein for Rat Nuclear factor NF-kappa-B p105 subunit
Protein for Rat Nuclear factor NF-kappa-B p105 subunit
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
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[8].
I I Hegab, H E El-Horany, M M. Elbatsh, et al.
[9].
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[10].
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[11].
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[12].
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[14].
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[15].
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[17].
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[19].
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[23].
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[24].
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[25].
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[26].
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[27].
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[28].
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[29].
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
tissue :
Testis .