Protein name:
14-3-3 protein zeta/delta ;
Alternative:
Protein kinase C inhibitor protein 1 (KCIP-1) ;Mitochondrial import stimulation factor S1 subunit ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homodimer. Heterodimerizes with YWHAE (By similarity). Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58 (By similarity). Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with CDK16 and with WEE1 (C-terminal). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with Thr-phosphorylated ITGB2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional acivity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with AANAT ('Thr-31' phosphorylated form); the interaction modulates AANAT enzymatic activity through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT ('Ser-205' phosphorylated form), can bind the other YWHAZ monomer with similar effect. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization (By similarity). Interacts with GAB2 and SAMSN1 (By similarity). Interacts with BSPRY. Interacts with BCL2L11.
Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Subcellular Location:
Cytoplasm
Melanosome
Located to stage I to stage IV melanosomes.
Protein Attributes:
50:
MDKNELVQKA | KLAEQAERYD | DMAACMKSVT | EQGAELSNEE | RNLLSVAYKN |
100:
VVGARRSSWR | VVSSIEQKTE | GAEKKQQMAR | EYREKIETEL | RDICNDVLSL |
150:
LEKFLIPNAS | QPESKVFYLK | MKGDYYRYLA | EVAAGDDKKG | IVDQSQQAYQ |
200:
EAFEISKKEM | QPTHPIRLGL | ALNFSVFYYE | ILNSPEKACS | LAKTAFDEAI |
245:
AELDTLSEES | YKDSTLIMQL | LRDNLTLWTS | DTQGDEAEAG | EGGEN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Chicken
Bovine
ELISA Kit for Rat 14-3-3 protein zeta/delta
ELISA Kit for Rat 14-3-3 protein zeta/delta
ELISA Kit for Rat 14-3-3 protein zeta/delta
ELISA Kit for Rat 14-3-3 protein zeta/delta
ELISA Kit for Rat 14-3-3 protein zeta/delta
CLIA Kit for Rat 14-3-3 protein zeta/delta
CLIA Kit for Rat 14-3-3 protein zeta/delta
CLIA Kit for Rat 14-3-3 protein zeta/delta
CLIA Kit for Rat 14-3-3 protein zeta/delta
CLIA Kit for Rat 14-3-3 protein zeta/delta
Polyclonal Antibody for Rat 14-3-3 protein zeta/delta
Polyclonal Antibody for Rat 14-3-3 protein zeta/delta
Polyclonal Antibody for Rat 14-3-3 protein zeta/delta
Polyclonal Antibody for Rat 14-3-3 protein zeta/delta
Polyclonal Antibody for Rat 14-3-3 protein zeta/delta
Monoclonal Antibody for Rat 14-3-3 protein zeta/delta
Monoclonal Antibody for Rat 14-3-3 protein zeta/delta
Monoclonal Antibody for Rat 14-3-3 protein zeta/delta
Monoclonal Antibody for Rat 14-3-3 protein zeta/delta
Monoclonal Antibody for Rat 14-3-3 protein zeta/delta
Protein for Rat 14-3-3 protein zeta/delta
Protein for Rat 14-3-3 protein zeta/delta
Protein for Rat 14-3-3 protein zeta/delta
Protein for Rat 14-3-3 protein zeta/delta
Protein for Rat 14-3-3 protein zeta/delta
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Wistar .
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
tissue :
Hippocampus .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Liver .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
tissue :
Lung .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 1-9; 12-49; 61-68; 92-115; 128-157 AND 213-222;ACETYLATION AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Fibroblast .
tissue :
Pheochromocytoma .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 12-55; 57-68; 84-115; 121-167; 159-187 AND 194-245;IDENTIFICATION BY MASS SPECTROMETRY
strain :
Sprague-Dawley .
tissue :
Brain .
tissue :
Hippocampus .
tissue :
Spinal cord .
7.
"Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis."
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Proc. Natl. Acad. Sci. U.S.A.98:8083-8088(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 28-41; 61-68 AND 128-139;INTERACTION WITH AANAT;IDENTIFICATION BY MASS SPECTROMETRY
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 58-245
strain :
Sprague-Dawley .
tissue :
Pineal gland .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;INTERACTION WITH BSPRY
10.
"Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection."
Thompson S.
,
Pearson A.N.
,
Ashley M.D.
,
Jessick V.
,
Murphy B.M.
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Gafken P.
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Meller R.
J. Biol. Chem.286:19331-19339(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH BCL2L11