Gene name:
C19orf80(UNQ599/PRO1185;Angptl8);
Protein name:
Betatrophin;
Alternative:
Lipasin;Angiopoietin-like protein 8;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with ANGPTL3.
Function:
Hormone that specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. Promotes pancreatic beta cell proliferation without insulin resistance. Also acts as a blood lipid regulator by regulating serum triglyceride levels; possibly by promoting ANGPTL3 cleavage.
Subcellular Location:
Secreted
Protein Attributes:
50:
MPVPALCLLW | ALAMVTRPAS | AAPMGGPELA | QHEELTLLFH | GTLQLGQALN |
100:
GVYRTTEGRL | TKARNSLGLY | GRTIELLGQE | VSRGRDAAQE | LRASLLETQM |
150:
EEDILQLQAE | ATAEVLGEVA | QAQKVLRDSV | QRLEVQLRSA | WLGPAYREFE |
198:
VLKAHADKQS | HILWALTGHV | QRQRREMVAQ | QHRLRQIQER | LHTAALPA

Vaild Sequence:
Related Databases
Uniprot: