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Index > 蛋白库 > C19orf80(基因名称) > Human
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  • C19orf80 (基因名称),
  • Betatrophin (蛋白名称 ),  BETAT_HUMAN from NCBI database.
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  • 常规注释
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  • 抗原注释
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  • 3D
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  • 预测片段
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  • 已验证序列
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  • 相关数据库
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  • 引用文献  (66)
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    • 基因名称:
    C19orf80(UNQ599/PRO1185;Angptl8);
    蛋白名称:
    Betatrophin;
    别名:
    Lipasin;Angiopoietin-like protein 8;
    物种:
    Human (Homo sapiens). 
    常规注释
    子单元:
    Interacts with ANGPTL3.
    功能说明:
    Hormone that specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. Promotes pancreatic beta cell proliferation without insulin resistance. Also acts as a blood lipid regulator by regulating serum triglyceride levels; possibly by promoting ANGPTL3 cleavage.
    亚细胞定位:
    Secreted
    蛋白属性:
    序列长度:
    198
    序列信息:
    50:
    MPVPALCLLW | ALAMVTRPAS | AAPMGGPELA | QHEELTLLFH | GTLQLGQALN | 
    100:
    GVYRTTEGRL | TKARNSLGLY | GRTIELLGQE | VSRGRDAAQE | LRASLLETQM | 
    150:
    EEDILQLQAE | ATAEVLGEVA | QAQKVLRDSV | QRLEVQLRSA | WLGPAYREFE | 
    198:
    VLKAHADKQS | HILWALTGHV | QRQRREMVAQ | QHRLRQIQER | LHTAALPA
    三维结构:
    N/A
    预测片段:
    请 登录.
    EIAab Sequence  已验证序列:
    请 登录.
    相关数据库
    KEGG:
    hsa:55908
    UniGene:
    Hs.534467
    STRING:
    9606.ENSP00000252453
    Uniprot:
    Q6UXH0
     
    FOR
    ELISA Kit for Human Betatrophin
    货号.:
    E11644h
    价格:
    Please sign in first.
    手册:
    查看手册。
    MSDS:
    Please sign in first.
    规格:
    96T
    范围:
    Please sign in first.
    CLIA Kit for Human Betatrophin
    货号.:
    U11644h
    价格:
    Please sign in first.
    手册:
    查看手册。
    MSDS:
    Please sign in first.
    规格:
    96T
    范围:
    Please sign in first.
    Polyclonal Antibody for Human Betatrophin
    货号.:
    P11644Rb-h
    价格:
    Please sign in first.
    规格:
    40ug/0.2ml
    Monoclonal Antibody for Human Betatrophin
    Protein for Human Betatrophin
    货号.:
    R11644h
    价格:
    Please sign in first.
    规格:
    1mg
    纯度:
    >90%

    研发数据

     12% SDS-PAGE analysis

             12% SDS-PAGE analysis

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    精确度
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    回收率
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    线性
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    引用产品文献
    [1].
    "Sustained spontaneous partial remission in a pediatric patient with type 1 diabetes"
    M Murillo, M Fonolleda, L Bosch, et al.
    From:Journal of Clinical and Translational Endocrinology: Case Reports
    [2].
    "ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ"
    Y Zhang, X Guo, Y Chen, et al.
    From:NATURE COMMUNICATIONS
    [3].
    "The Correlation Between Circulating Betatrophin and Insulin Resistance in General Population: A Meta-Analysis"
    JL Xu, YY Lin, H Zhou, et al.
    From:Hormone and Metabolic Research
    [4].
    "Biphasic changes in angiopoietin-like 8 level after laparoscopic sleeve gastrectomy and type 2 diabetes remission during a 1-year follow-up"
    E Al-Shawaf, J Tuomilehto, H Arefanian, et al.
    From:Surgery for Obesity and Related Diseases
    [5].
    "Triglyceride-mediated influence of serum angiopoietin-like protein 8 on subclinical atherosclerosis in type 2 diabetic patients: results from the GDMD study in China"
    TP Zheng, B Ge, HB Liu, et al.
    From:Cardiovascular Diabetology
    [6].
    "The negative effect of ANGPTL8 on HDL-mediated cholesterol efflux capacity"
    MD Luo, ZY Zhang, S Wang, et al.
    From:Cardiovascular Diabetology
    [7].
    "Angiopoietin-like protein 8: an attractive biomarker for the evaluation of subjects with insulin resistance and related disorders"
    S Wang, XF Hong, ZG Tu, et al.
    From:Diabetes Research and Clinical Practice
    [8].
    "Angiopoietin-like 8 (ANGPTL8) expression is regulated by miR-143-3p in human hepatocytes"
    J K. DiStefano
    From:Gene
    [9].
    "Angiopoietin-like protein 8 in early pregnancy improves the prediction of gestational diabetes"
    Y Huang, X Chen, XH Chen, et al.
    From:Diabetologia
    [10].
    "Relationship Between Angiopoietin-Like Protein 8 and Fasting Serum Triglyceride Level"
    H Yamada, I Kusaka, R Saikawa, et al.
    From:Journal of Clinical Medicine research
    [11].
    "Decreased circulating levels of ANGPTL8 in Graves’ disease patients"
    HX Li, MJ Xu, L Zhao, et al.
    From:Hormones-International Journal of Endocrinology and Metabolism
    [12].
    "Angiopoietin-like protein 8/betatrophin correlates with hepatocellular lipid content independent of insulin resistance in non-alcoholic fatty liver disease patients"
    B S Hong, J Liu, J Zheng, et al.
    From:Journal of Diabetes Investigation
    [13].
    "ANGPTL8 (betatrophin) role in diabetes and metabolic diseases"
    M Abu-Farha, J Abubaker, J Tuomilehto.
    From:Diabetes/Metabolism Research and Reviews
    [14].
    "Apolipoprotein CIII may mediate the impacts of angiopoietin-like protein 8 on triglyceride metabolism"
    M Luo, X Su, Y Yang, et al.
    From:Lipids in Health and Disease
    [15].
    "Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes"
    Daniel Espes, Joey Lau, Per-Ola Carlsson
    From:Diabetologia
    [16].
    "Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individuals"
    A Fenzl, BK Itariu, L Kosi, et al.
    From:Diabetologia
    [17].
    "Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes"
    D Espes, M Martinell, PO Carlsson
    From:International journal of endocrinology
    [18].
    "Increased Circulating Levels of Betatrophin in Newly Diagnosed Type 2 Diabetic Patients"
    H Hu, W Sun, S Yu, et al.
    From:Diabetes Care
    [19].
    "Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity"
    Z Fu, F Berhane, A Fite, et al.
    From:Scientific Reports
    [20].
    "An explanation for recent discrepancies in levels of human circulating betatrophin"
    Z Fu, AB Abou-Samra, R Zhang
    From:Diabetologia
    [21].
    "Characterisation of betatrophin concentrations in childhood and adolescent obesity and insulin resistance"
    S Wu, H Gao, Y Ma, et al.
    From:Pediatric Diabetes
    [22].
    "Correlation of circulating betatrophin concentrations with insulin secretion capacity, evaluated by glucagon stimulation test"
    S Tokumoto, Y Hamamoto, K Fujimoto, et al.
    From:Diabetes Medicine
    [23].
    "Increased levels of irisin in people with long-standing Type 1 diabetes"
    D Espes, J Lau, PO Carlsson
    From:Diabetic Medicine
    [24].
    "Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes"
    H Yamada, T Saito, A Aoki, et al.
    From:Endocrine journal
    [25].
    "Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance"
    X Xie, T Gao, M Yang, et al.
    From:Diabetology & metabolic syndrome
    [26].
    "Circulating Levels of Betatrophin and Irisin Are Not Associated with Pancreatic β-Cell Function in Previously Diagnosed Type 2 Diabetes Mellitus ..."
    L Wang, J Song, C Wang, et al.
    From:Journal of Diabetes Research
    [27].
    "Relationship of betatrophin with youth onset type 2 diabetes among Asian Indians"
    K Gokulakrishnan, K Manokaran, GK Pandey, et al.
    From:Diabetes Research and Clinical Practice
    [28].
    "AMP-activated protein kinase suppresses the expression of LXR/SREBP-1 signaling-induced ANGPTL8 in HepG2 cells"
    Lee J, Hong SW, Park SE, et al.
    From:Molecular and Cellular Endocrinology
    [29].
    "Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: A brown adipose tissue-derived endocrine factor with a potential role in fetal growth"
    Martinez-Perez B, Ejarque M, Gutierrez C, et al.
    From:Translational Research
    [30].
    "ANGPTL8/Betatrophin R59W variant is associated with higher glucose level in non-diabetic Arabs living in Kuwaits"
    Abu-Farha M, Melhem M, Abubaker J, et al.
    From:Lipids in health and disease
    [31].
    "Betatrophin Levels were Increased in Pregnant Women with or without Gestational Diabetes Mellitus and Associated with Beta Cell Function"
    Huang Y, Fang C, Ma Z, et al.
    From:Rev Bras Ginecol Obstet
    [32].
    "Circulating angiopoietin-like protein 8 (ANGPTL8) and ANGPTL3 concentrations in relation to anthropometric and metabolic profiles in Korean children"
    Chung H S, Lee M J, Hwang S Y, et al.
    From:Cardiovascular diabetology
    [33].
    "Circulating angiopoietin-like protein 8 (betatrophin) association with HsCRP and metabolic syndrome"
    Abu-Farha M, Abubaker J, Al-Khairi I, et al.
    From:Cardiovascular Diabetology
    [34].
    "Circulating ANGPTL8/betatrophin is increased in obesity and reduced after exercise training"
    Abu-Farha M, Sriraman D, Cherian P, et al.
    From:PloS one
    [35].
    "Circulating Betatrophin in Healthy Control and Type 2 Diabetic Subjects and its Association with Metabolic Parameters"
    Al-Daghri N M, Rahman S, Sabico S, et al.
    From:Journal of Diabetes and its Complications
    [36].
    "Circulating Betatrophin Is Increased in Patients with Overt and Subclinical Hypothyroidism"
    Han C, Xia X, Liu A, et al.
    From:BioMed research international
    [37].
    "Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function"
    Chen C C, Susanto H, Chuang W H, et al.
    From:Cardiovascular diabetology
    [38].
    "Increased Cord Blood Betatrophin Levels in the Offspring of Mothers with Gestational Diabetes"
    Xie X, Gao H, Wu S, et al.
    From:PloS one
    [39].
    "Lipasin, a biomarker of diabetic retinopathy"
    Fang C, Huang Y, Guo H, et al.
    From:Diabetes research and clinical practice
    [40].
    "Positive Association Between Betatrophin and Diabetic Retinopathy Risk in Type 2 Diabetes Patients"
    Wang Y Y, Zhang D, Jiang Z Y, et al.
    From:Hormone and Metabolic Research
    [41].
    "Possible proteolyzation of circulating betatrophin in human serum"
    S. Tokumoto, Y. Hamamoto, E. Okamura, et al
    From:Journal of Diabetes Investigation
    [42].
    "Serum betatrophin level increased in subjects with metabolic syndrome: a case-control study"
    Zhu J Z, Li C X, Dai Y N, et al
    From:Nutrición Hospitalaria
    [43].
    "The Arg59Trp variant in ANGPTL8 (betatrophin) is associated with total and HDL-cholesterol in American Indians and Mexican Americans and ..."
    Hanson R L, Leti F, Tsinajinnie D, et al.
    From:Molecular genetics and metabolism
    [44].
    "Betatrophin Acts as a Diagnostic Biomarker in Type 2 Diabetes Mellitus and Is Negatively Associated with HDL-Cholesterol"
    Yi M, Chen R, Yang R, et al.
    From:International journal of endocrinology
    [45].
    "betatrophin in Diabetes Mellitus: the Epidemiological Evidence in Humans"
    D Espes, M Martinell, H Liljebäck, PO Carlsson
    From:Current Diabetes Reports
    [46].
    "Circulating betatrophin correlates with triglycerides and postprandial glucose among different glucose tolerance statuses—a case-control study"
    Gao T, Jin K, Chen P, et al.
    From:PloS one
    [47].
    "Circulating betatrophin in patients with type 2 diabetes: a meta-analysis"
    Li S, Liu D, Li L, et al.
    From:Journal of diabetes research
    [48].
    "Circulating betatrophin is strongly increased in pregnancy and gestational diabetes mellitus"
    Trebotic L K, Klimek P, Thomas A, et al
    From:PloS one
    [49].
    "Circulating betatrophin levels are increased in patients with type 2 diabetes and associated with insulin resistance"
    Chen X, Lu P, He W, et al
    From:J Clin Endocrinol Metab.
    [50].
    "Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance"
    Abu-Farha M, Abubaker J, Noronha F
    From:scientific reports
    [51].
    "Irisin 与 betatrophin 的关系以及对 β 细胞增殖作用的研究"
    谢心苗
    From:南方医科大学
    [52].
    "Lack of associations between betatrophin/ANGPTL8 level and C-peptide in type 2 diabetic subjects"
    Abu-Farha M, Abubaker J, Noronha F, et al
    From:Cardiovascular diabetology
    [53].
    "Increased serum levels of betatrophin in pancreatic cancer-associated diabetes"
    Susanto H, Liu T Y, Chen C C
    From:Oncotarget
    [54].
    "Altered Concentrations in Dyslipidemia Evidence a Role for ANGPTL8/Betatrophin in Lipid Metabolism in Humans"
    Gómez-Ambrosi J, Pascual-Corrales E, Catalán V, et al.
    From:The Journal of Clinical Endocrinology & Metabolism
    [55].
    "Weight loss partially restores glucose-driven betatrophin response in humans"
    Maurer L, Brachs S, Decker A M, et al.
    From:The Journal of Clinical Endocrinology & Metabolism
    [56].
    "Vitamin D modifies the associations between circulating betatrophin and cardiometabolic risk factors among youths at risk for metabolic syndrome"
    Fu J, Hou C, Li L, et al.
    From:Cardiovascular Diabetology
    [57].
    "Increased angiopoietin-like protein 8 levels in patients with type 2 diabetes and cardiovascular disease"
    Huang Y, Fang C, Guo H, et al.
    From:Diabetes Research and Clinical Practice
    [58].
    "Circulating betatrophin in pregnant individuals with gestational diabetes mellitus and normal glucose tolerance"
    Zheng D, Cui C, Yu M, et al.
    From:INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
    [59].
    "Increased ANGPTL3, 4 and ANGPTL8/betatrophin expression levels in obesity and T2D"
    Abu-Farha M, Al-Khairi I, Cherian P, et al.
    From:Lipids in Health and Disease
    [60].
    "ANGPTL8 as a new determinant of type 2 diabetes remission after bariatric surgery"
    M Ejarque, M Borlaug, N Vilarrasa, et al.
    From:Translational Research
    [61].
    "Plasma Betatrophin Levels of Subjects Classified with Normal,Impaired, and Diabetic Glucose Tolerance, and Subjects withImpaired Fasting Glucose"
    Sibel O, Burak O, Eda Merve K, et al.
    From:Hormone and Metabolic Research
    [62].
    "ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives"
    Christian von L, Andreas F. H. Pfeiffer, Johan F. L, et al.
    From:Hormone and Metabolic Research
    [63].
    "Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery"
    Miriam E, Marianne B, Nuria V, et al.
    From:Translational Research
    [64].
    "Insulin upregulates betatrophin expression via PI4K/Akt pathway"
    Puhan L, Xi C, Zeqing Z, et al.
    From:Scientific Reports
    [65].
    "Increased plasma and adipose tissue levels of ANGPTL8/Betatrophin and ANGPTL4 in people with hypertension"
    M Abu-Farha, P Cherian, D Sriraman, et al.
    From:Lipids in Health and Disease
    [66].
    "Partial remission and early stages of pediatric type 1 diabetes display immunoregulatory changes. A pilot study"
    A Villalba, M Fonolleda, M Murillo, et al.
    From:Translational Research
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      "Circulating betatrophin levels are increased in patients with type 2 diabetes and associated with insulin resistance."
      Chen X. , Lu P. , He W. , Zhang J. , Liu L. , Yang Y. , Liu Z. , Xie J. , Shao S. , Du T. , Su X. , Zhou X. , Hu S. , Yuan G. , Zhang M. , Zhang H. , Liu L. , Wang D. , more...
      J. Clin. Endocrinol. Metab.0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN NIDDM
    17. 17.
      "Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity."
      Fu Z. , Berhane F. , Fite A. , Seyoum B. , Abou-Samra A.B. , Zhang R.
      Sci. Rep.4:5013-5013(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN NIDDM
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