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Index > Protein center > HLA-C(Gene name) > Human
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  • HLA-C (Gene name),
  • HLA class I histocompatibility antigen, Cw-12 alpha chain (Protein name ),  1C12_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    HLA-C(HLAC);
    Protein name:
    HLA class I histocompatibility antigen, Cw-12 alpha chain;
    Alternative:
    MHC class I antigen Cw*12;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein.
    Function:
    Involved in the presentation of foreign antigens to the immune system.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    366
    Sequence:
    50:
    MRVMAPRTLI | LLLSGALALT | ETWACSHSMR | YFYTAVSRPG | RGEPRFIAVG | 
    100:
    YVDDTQFVRF | DSDAASPRGE | PRAPWVEQEG | PEYWDRETQK | YKRQAQADRV | 
    150:
    SLRNLRGYYN | QSEAGSHTLQ | RMYGCDLGPD | GRLLRGYDQS | AYDGKDYIAL | 
    200:
    NEDLRSWTAA | DTAAQITQRK | WEAAREAEQW | RAYLEGTCVE | WLRRYLENGK | 
    250:
    ETLQRAEHPK | THVTHHPVSD | HEATLRCWAL | GFYPAEITLT | WQRDGEDQTQ | 
    300:
    DTELVETRPA | GDGTFQKWAA | VVVPSGEEQR | YTCHVQHEGL | PEPLTLRWEP | 
    350:
    SSQPTIPIVG | IVAGLAVLAV | LAVLGAVMAV | VMCRRKSSGG | KGGSCSQAAS | 
    366:
    SNSAQGSDES | LIACKA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    Pfam:
    SMR:
    String:
    UniGene:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    ELISA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    ELISA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    ELISA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    ELISA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    ELISA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    ELISA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    ELISA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    ELISA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    ELISA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    ELISA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    ELISA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    ELISA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    ELISA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    CLIA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    CLIA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    CLIA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    CLIA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    CLIA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    CLIA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    CLIA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    CLIA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    CLIA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    CLIA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    CLIA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    CLIA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    CLIA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    CLIA Kit for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Polyclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Polyclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Polyclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Polyclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Polyclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Polyclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Polyclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Polyclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Polyclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Polyclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Polyclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Polyclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Polyclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Polyclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Monoclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Monoclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Monoclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Monoclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Monoclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Monoclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Monoclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Monoclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Monoclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Monoclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Monoclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Monoclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Monoclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Monoclonal Antibody for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Protein for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Protein for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Protein for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Protein for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Protein for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Protein for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Protein for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Protein for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Protein for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Protein for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Protein for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Protein for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Protein for Human HLA class I histocompatibility antigen, Cw-12 alpha chain
    Protein for Human HLA class I histocompatibility antigen, Cw-12 alpha chain

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    Linearity
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    References
    1. 1.
      "Cloning and analysis of HLA class I cDNA encoding a new HLA-C specificity Cx52."
      Takata H. , Inoko H. , Ando A. , Haranaka M. , Watanabe B. , Tsuji K. , Iri H.
      Immunogenetics28:265-270(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*12:02)
    2. 2.
      "The structure and expression of genes encoding serologically undetected HLA-C locus antigens."
      Takiguchi M. , Nishimura I. , Hayashi H. , Karaki S. , Kariyone A. , Kano K.
      J. Immunol.143:1372-1378(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE CW*12:02)
    3. 3.
      "Molecular cloning and polymerase chain reaction-sequence-specific oligonucleotide detection of the allele encoding the novel allospecificity HLA-Cw6.2 (Cw*1502) in Spanish gypsies."
      Vilches C. , de Pablo R. , Herrero M.J. , Moreno M.E. , Kreisler M.
      Hum. Immunol.37:259-263(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*12:02)
    4. 4.
      "HLA-C alleles in Japanese and a novel allele from a non-Japanese individual."
      Wang H. , Tokunaga K.
      Submitted (1996-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 1-298 (ALLELE CW*12:02)
      tissue: Peripheral blood.
    5. 5.
      "An HLA-Cw allele detected by PCR-SSO."
      Greville W.D. , Ng G. , Kennedy A. , Kennedy C.T. , Le T. , Dodd R. , Wallace R. , Dunckley H.
      Submitted (1999-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE CW*12:02)
    6. 6.
      "Identification of two new HLA-C alleles, Cw*1203 and Cw*1402, from the sequence analysis of seven HLA homozygous cell lines carrying HLA-C blank."
      Cereb N. , Choi J.W. , Lee S. , Maye P. , Kong Y. , Yang S.Y.
      Tissue Antigens44:193-195(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*12:03)
      tissue: Blood.
    7. 7.
      Pablo R.
      Submitted (1994-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ALLELE CW*12:03)
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ALLELE CW*12:03)
    9. 9.
      "HLA-C locus polymorphisms in Japanese."
      Wang H. , Tokunaga K.
      Submitted (1995-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 1-298 (ALLELE CW*12:03)
      tissue: Peripheral blood.
    10. 10.
      "A new pair of HLA-C alleles, Cw*12042 and Cw*1203, differing at the KIR-related dimorphism of codons 77-80."
      Vilches C. , Bunce M. , van Dam M. , de Pablo R.
      Tissue Antigens51:101-105(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*12:04)
    11. 11.
      Tatari Z.
      Submitted (1996-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 1-227 (ALLELE CW*12:04)
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES CW*12:04 AND CW*12:06)
    13. 13.
      "Sequence of four new HLA-Cw alleles: a possible role of interallelic recombination."
      Grundschober C. , Labonne M. , Javaux F. , Steiner Q.G. , Gebuhrer L. , Tiercy J.-M.
      Tissue Antigens51:72-79(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ALLELE CW*12:05)
    14. 14.
      "Nucleotide sequence of an HLA-Cw*1203 variant allele with a new polymorphic position in exon 2."
      Davey S. , Dunn P.P.
      Submitted (1999-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE CW*12:07)
    15. 15.
      "Sequence of two new HLA-Cw alleles: HLA-Cw*0313 and HLA-Cw*1208."
      Cox S.T. , Ogilvie H. , Bohan E.M. , Holman R. , Prentice H.G. , Potter M. , Madrigal J.A. , Little A.-M.
      Tissue Antigens59:49-51(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE CW*12:08)
    16. 16.
      "Identification of confirmatory sequence of Cw*1209."
      Day S. , Carter V.
      Submitted (2003-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE CW*12:09)
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-208 AND THR-363
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