Protein name:
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform ;
Alternative:
PP2A subunit A isoform R1-alpha ;PP2A subunit A isoform PR65-alpha ;
Organism:
Pig (Sus scrofa).
General Annotation
Sub Unit:
PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9. Interacts with TP53 and SGOL1. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). Interacts with PLA2G16; this interaction might decrease PP2A activity.
Function:
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.
Subcellular Location:
Cytoplasm
Chromosome
centromere
Centromeric localization requires the presence of BUB1.
Protein Attributes:
50:
MAAADGDDSL | YPIAVLIDEL | RNEDVQLRLN | SIKKLSTIAL | ALGVERTRSE |
100:
LLPFLTDTIY | DEDEVLLALA | EQLGTFTTLV | GGPEYVHCLL | PPLESLATVE |
150:
ETVVRDKAVE | SLRAISHEHS | PSDLEAHFVP | LVKRLAGGDW | FTSRTSACGL |
200:
FSVCYPRVSS | AVKAELRQYF | RNLCSDDTPM | VRRAAASKLG | EFAKVLELDN |
250:
VKSEIIPMFS | NLASDEQDSV | RLLAVEACVN | IAQLLPQEDL | EALVMPTLRQ |
300:
AAEDKSWRVR | YMVADKFTEL | QKAVGPEITK | TDLVPAFQNL | MKDCEAEVRA |
350:
AASHKVKEFC | ENLSADCREN | VIMTQILPCI | KELVSDANQH | VKSALASVIM |
400:
GLSPILGKDN | TIEHLLPLFL | AQLKDECPEV | RLNIISNLDC | VNEVIGIRQL |
450:
SQSLLPAIVE | LAEDAKWRVR | LAIIEYMPLL | AGQLGVEFFD | EKLNSLCMAW |
500:
LVDHVYAIRE | AATSNLKKLV | EKFGKEWAHA | TIIPKVLAMS | GDPNYLHRMT |
550:
TLFCINVLSE | VCGQDITTKH | MLPTVLRMAG | DPVANVRFNV | AKSLQKIGPI |
589:
LDNSTLQSEV | KPILEKLTQD | QDVDVKYFAQ | EALTVLSLA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Pig
ELISA Kit for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
ELISA Kit for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
ELISA Kit for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
ELISA Kit for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
CLIA Kit for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
CLIA Kit for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
CLIA Kit for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
CLIA Kit for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Polyclonal Antibody for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Polyclonal Antibody for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Polyclonal Antibody for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Polyclonal Antibody for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Monoclonal Antibody for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Monoclonal Antibody for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Monoclonal Antibody for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Monoclonal Antibody for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Protein for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Protein for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Protein for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Protein for Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]