Ppp2r2b ELISA Kit for Rat(Rattus norvegicus) | EIAab.comPpp2r2b ELISA Kit for Rat(Rattus norvegicus)

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Ppp2r2b (Gene name),

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (Protein name ), 2ABB_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ppp2r2b;

Protein name:

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform;

Alternative:

PP2A subunit B isoform BRB;PP2A subunit B isoform B55-beta;PP2A subunit B isoform R2-beta;PP2A subunit B isoform PR55-beta;PP2A subunit B isoform beta;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with TOMM22.

Function:

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance.

Subcellular Location:

Isoform 2 Cytoplasm Mitochondrion Mitochondrion outer membrane Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity.

Protein Attributes:

Sequence length:

443

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

443:

KDEISVDSLD | FSKKILHTAW | HPSENIIAVA | ATNNLYIFQD | KVN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10116.ENSRNOP00000041264

UniGene:

Rn.44437

Pfam:

PF00400

String:

P36877

KEGG:

rno:60660

Uniprot:

P36877

FOR

ELISA Kit for Rat Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

CLIA Kit for Rat Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

Polyclonal Antibody for Rat Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

Monoclonal Antibody for Rat Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

Protein for Rat Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"cDNA cloning of BR gamma, a novel brain-specific isoform of the B regulatory subunit of type-2A protein phosphatase."
Akiyama N. , Shima H. , Hatano Y. , Osawa Y. , Sugimura T. , Nagao M.
Eur. J. Biochem.230:766-772(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: Sprague-Dawley.
tissue: Brain.
2.

"A developmentally regulated, neuron-specific splice variant of the variable subunit Bbeta targets protein phosphatase 2A to mitochondria and modulates apoptosis."
Dagda R.K. , Zaucha J.A. , Wadzinski B.E. , Strack S.
J. Biol. Chem.278:24976-24985(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INDUCTION;MUTAGENESIS OF 165-ARG-ARG-166;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain: Sprague-Dawley.
tissue: Brain.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Testis.
4.

"Expression of PP2A B regulatory subunit beta isotype in rat testis."
Hatano Y. , Shima H. , Haneji T. , Miura A.B. , Sugimura T. , Nagao M.
FEBS Lett.324:71-75(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-177 (ISOFORM 1);TISSUE SPECIFICITY
tissue: Testis.
5.

"Unfolding-resistant translocase targeting: a novel mechanism for outer mitochondrial membrane localization exemplified by the Bbeta2 regulatory subunit of protein phosphatase 2A."
Dagda R.K. , Barwacz C.A. , Cribbs J.T. , Strack S.
J. Biol. Chem.280:27375-27382(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TOMM22;MUTAGENESIS OF ISOFORM 2;SUBCELLULAR LOCATION
6.

"Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
Hoffert J.D. , Pisitkun T. , Wang G. , Shen R.-F. , Knepper M.A.
Proc. Natl. Acad. Sci. U.S.A.103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-275; TYR-295 AND THR-298;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
7.

"The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission."
Dagda R.K. , Merrill R.A. , Cribbs J.T. , Chen Y. , Hell J.W. , Usachev Y.M. , Strack S.
J. Biol. Chem.283:36241-36248(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION

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