Gene name:
PPP2R2D (RCJMB04_22l15) ;
Protein name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform ;
Alternative:
PP2A subunit B isoform PR55-delta ;PP2A subunit B isoform B55-delta ;PP2A subunit B isoform delta ;PP2A subunit B isoform R2-delta ;
Organism:
Chicken (Gallus gallus).
General Annotation
Sub Unit:
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ENSA (when phosphorylated at 'Ser-67') and ARPP19 (when phosphorylated at 'Ser-62'), leading to inhibit PP2A activity.
Function:
B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MAGVAGGGGN | GNDFQWCFSQ | VQGAVDEDVA | EADIISTVEF | NYSGDLLATG |
100:
DKGGRVVIFQ | REQENKSRPH | SRGEYNVYST | FQSHEPEFDY | LKSLEIEEKI |
150:
NKIRWLPQQN | AAHFLLSTND | KTIKLWKISE | RDKRAEGYNL | KDEDGRLRDP |
200:
FKITALRVPI | LKPMDLMVEA | SPRRIFANAH | TYHINSISVN | SDHETYLSAD |
250:
DLRINLWHLE | ITDRSFNIVD | IKPANMEELT | EVITAAEFHP | HHCNVFVYSS |
300:
SKGTIRLCDM | RSSALCDRHS | KFFEEPEDPS | SRSFFSEIIS | SISDVKFSHS |
350:
GRYMMTRDYL | SVKVWDLNME | NRPVETYQVH | EYLRSKLCSL | YENDCIFDKF |
400:
ECCWNGSDGA | IMTGSYNNFF | RMFDRNTRRD | ITLEASRESS | KPRAILKPRK |
450:
VCTGGKRKKD | EINVDSLDFN | KKILHTAWHP | MENIIAVAAT | NNLYIFQDKI |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Chicken
Human
Rat
Mouse
ELISA Kit for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
ELISA Kit for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
ELISA Kit for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
ELISA Kit for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
CLIA Kit for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
CLIA Kit for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
CLIA Kit for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
CLIA Kit for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Polyclonal Antibody for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Polyclonal Antibody for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Polyclonal Antibody for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Polyclonal Antibody for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Monoclonal Antibody for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Monoclonal Antibody for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Monoclonal Antibody for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Monoclonal Antibody for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Protein for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Protein for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Protein for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Protein for Chicken Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B.
,
Kierzek A.M.
,
Arakawa H.
,
Bezzubov Y.
,
Zaim J.
,
Fiedler P.
,
Kutter S.
,
Blagodatski A.
,
Kostovska D.
,
Koter M.
,
Plachy J.
,
Carninci P.
,
Hayashizaki Y.
,
Buerstedde J.-M.
Genome Biol.6:R6.1-R6.9(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
CB .
tissue :
Bursa of Fabricius .