HTR1A ELISA Kit for Human(Homo sapiens) | EIAab.comHTR1A ELISA Kit for Human(Homo sapiens)

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HTR1A (Gene name),

5-hydroxytryptamine receptor 1A (Protein name ), 5HT1A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

HTR1A(ADRB2RL1;ADRBRL1);

Protein name:

5-hydroxytryptamine receptor 1A(5-HT-1A;5-HT1A);

Alternative:

Serotonin receptor 1A;G-21;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

422

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

422:

AYFNKDFQNA | FKKIIKCKFC | RQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000316244

MIM:

109760

SMR:

P08908

KEGG:

hsa:3350

UniGene:

Hs.247940

Pfam:

PF00001

String:

P08908

Uniprot:

P08908

FOR

ELISA Kit for Human 5-HT-1A

CLIA Kit for Human 5-HT-1A

Polyclonal Antibody for Human 5-HT-1A

Monoclonal Antibody for Human 5-HT-1A

Protein for Human 5-HT-1A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins."
Kobilka B.K. , Frielle T. , Collins S. , Yang-Feng T.L. , Kobilka T.S. , Francke U. , Lefkowitz R.J. , Caron M.G.
Nature329:75-79(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY;SUBCELLULAR LOCATION
2.

"Nucleotide and deduced amino acid sequence of the human serotonin 5-HT1a receptor gene."
Saltzman A.G. , Morse B. , Felder S.
Submitted (1991-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

Levy F.O. , Gudermann T. , Birnbaumer M. , Kaumann A.J. , Birnbaumer L.
Submitted (1992-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Human-specific amino acid changes found in 103 protein-coding genes."
Kitano T. , Liu Y.-H. , Ueda S. , Saitou N.
Mol. Biol. Evol.21:936-944(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III , Ikeda S.R. , Aronstam R.S.
Submitted (2002-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.

"A polymerase chain reaction mediated by a single primer: cloning of genomic sequences adjacent to a serotonin receptor protein coding region."
Parks C.L. , Chang L.S. , Shenk T.
Nucleic Acids Res.19:7155-7160(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9
8.

"Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine."
Aune T.M. , McGrath K.M. , Sarr T. , Bombara M.P. , Kelley K.A.
J. Immunol.151:1175-1183(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 200-365;FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
9.

"The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor."
Fargin A. , Raymond J.R. , Lohse M.L. , Kobilka B.K. , Caron M.G. , Lefkowitz R.J.
Nature335:358-360(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
10.

"Agonist-induced desensitization and loss of high-affinity binding sites of stably expressed human 5-HT1A receptors."
Harrington M.A. , Shaw K. , Zhong P. , Ciaranello R.D.
J. Pharmacol. Exp. Ther.268:1098-1106(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
Vasilescu J. , Zweitzig D.R. , Denis N.J. , Smith J.C. , Ethier M. , Haines D.S. , Figeys D.
J. Proteome Res.6:298-305(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-334
tissue: Lung adenocarcinoma.
12.

"Serotonin receptors."
Nichols D.E. , Nichols C.D.
Chem. Rev.108:1614-1641(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
13.

"5-HT1A receptor-regulated signal transduction pathways in brain."
Polter A.M. , Li X.
Cell. Signal.22:1406-1412(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
14.

"Serotonin receptors - from molecular biology to clinical applications."
Pytliak M. , Vargova V. , Mechirova V. , Felsoci M.
Physiol. Res.60:15-25(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
15.

"Menstrual cycle-dependent febrile episode mediated by sequence-specific repression of poly(ADP-ribose) polymerase-1 on the transcription of the human serotonin receptor 1A gene."
Jiang Y.C. , Wu H.M. , Cheng K.H. , Sunny Sun H.
Hum. Mutat.33:209-217(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PFMC
16.

"Role of glycosphingolipids in the function of human serotonin(1)A receptors."
Singh P. , Paila Y.D. , Chattopadhyay A.
J. Neurochem.123:716-724(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
17.

"Post-synaptic density-95 (PSD-95) binding capacity of G-protein-coupled receptor 30 (GPR30), an estrogen receptor that can be identified in hippocampal dendritic spines."
Akama K.T. , Thompson L.I. , Milner T.A. , McEwen B.S.
J. Biol. Chem.288:6438-6450(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
18.

"Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28."
Nakhai B. , Nielsen D.A. , Linnoila M. , Goldman D.
Biochem. Biophys. Res. Commun.210:530-536(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SER-22 AND VAL-28
19.

"Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia."
Kawanishi Y. , Harada S. , Tachikawa H. , Okubo T. , Shiraishi H.
Am. J. Med. Genet.81:434-439(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEU-16 AND ASP-273

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