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Index > Protein center > HTR2A(Gene name) > Human
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  • HTR2A (Gene name),
  • 5-hydroxytryptamine receptor 2A (Protein name ),  5HT2A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    HTR2A(HTR2);
    Protein name:
    5-hydroxytryptamine receptor 2A(5-HT-2;5-HT-2A);
    Alternative:
    Serotonin receptor 2A;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2.
    Function:
    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Localizes to the post-synaptic thickening of axo-dendritic synapses.
    Protein Attributes:
    Sequence length:
    471
    Sequence:
    50:
    MDILCEENTS | LSSTTNSLMQ | LNDDTRLYSN | DFNSGEANTS | DAFNWTVDSE | 
    100:
    NRTNLSCEGC | LSPSCLSLLH | LQEKNWSALL | TAVVIILTIA | GNILVIMAVS | 
    150:
    LEKKLQNATN | YFLMSLAIAD | MLLGFLVMPV | SMLTILYGYR | WPLPSKLCAV | 
    200:
    WIYLDVLFST | ASIMHLCAIS | LDRYVAIQNP | IHHSRFNSRT | KAFLKIIAVW | 
    250:
    TISVGISMPI | PVFGLQDDSK | VFKEGSCLLA | DDNFVLIGSF | VSFFIPLTIM | 
    300:
    VITYFLTIKS | LQKEATLCVS | DLGTRAKLAS | FSFLPQSSLS | SEKLFQRSIH | 
    350:
    REPGSYTGRR | TMQSISNEQK | ACKVLGIVFF | LFVVMWCPFF | ITNIMAVICK | 
    400:
    ESCNEDVIGA | LLNVFVWIGY | LSSAVNPLVY | TLFNKTYRSA | FSRYIQCQYK | 
    450:
    ENKKPLQLIL | VNTIPALAYK | SSQLQMGQKK | NSKQDAKTTD | NDCSMVALGK | 
    471:
    QHSEEASKDN | SDGVNEKVSC | V
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    UniGene:
    SMR:
    Pfam:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human 5-HT-2
    Cat.:
    E10283h
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    ELISA Kit for Human 5-HT-2
    Cat.:
    E10283r
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    96T
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    ELISA Kit for Human 5-HT-2
    Cat.:
    E10283d
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    Packing:
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    ELISA Kit for Human 5-HT-2
    Cat.:
    E10283m
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    ELISA Kit for Human 5-HT-2
    Cat.:
    E10283p
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    ELISA Kit for Human 5-HT-2
    Cat.:
    E10283b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human 5-HT-2
    Cat.:
    U10283p
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    Packing:
    96T
    CLIA Kit for Human 5-HT-2
    Cat.:
    U10283r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human 5-HT-2
    Cat.:
    U10283h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human 5-HT-2
    Cat.:
    U10283b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human 5-HT-2
    Cat.:
    U10283d
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    Packing:
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    CLIA Kit for Human 5-HT-2
    Cat.:
    U10283m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human 5-HT-2
    Polyclonal Antibody for Human 5-HT-2
    Cat.:
    P10283Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human 5-HT-2
    Polyclonal Antibody for Human 5-HT-2
    Cat.:
    P10283Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human 5-HT-2
    Polyclonal Antibody for Human 5-HT-2
    Cat.:
    P10283Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human 5-HT-2
    Monoclonal Antibody for Human 5-HT-2
    Monoclonal Antibody for Human 5-HT-2
    Monoclonal Antibody for Human 5-HT-2
    Monoclonal Antibody for Human 5-HT-2
    Monoclonal Antibody for Human 5-HT-2
    Protein for Human 5-HT-2
    Protein for Human 5-HT-2
    Protein for Human 5-HT-2
    Protein for Human 5-HT-2
    Protein for Human 5-HT-2
    Protein for Human 5-HT-2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes."
      Saltzman A.G. , Morse B. , Whitman M.M. , Ivanshchenko Y. , Jaye M. , Felder S.
      Biochem. Biophys. Res. Commun.181:1469-1478(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain stem.
    2. 2.
      "The human 5-HT2 receptor is encoded by a multiple intron-exon gene."
      Chen K. , Yang W. , Grimsby J. , Shih J.C.
      Brain Res. Mol. Brain Res.14:20-26(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor."
      Cook E.H. Jr. , Fletcher K.E. , Wainwright M. , Marks N. , Yan S.Y. , Leventhal B.L.
      J. Neurochem.63:465-469(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Platelet.
    4. 4.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III , Ikeda S.R. , Aronstam R.S.
      Submitted (2002-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Testis.
      tissue: Thalamus.
    6. 6.
      "The DNA sequence and analysis of human chromosome 13."
      Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
      Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    9. 9.
      "Cloning and nucleotide sequence of the human(5HT) type 2 receptor."
      Tritch R.J. , Robinson D.L. , Sahagan B.G. , Horlick R.A.
      Submitted (1992-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-464 (ISOFORM 1)
      tissue: Brain.
    10. 10.
      "Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes."
      Stam N.J. , van Huizen F. , van Alebeek C. , Brands J. , Dijkema R. , Tonnaer J.A. , Olijve W.
      Eur. J. Pharmacol.227:153-162(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 105-218;FUNCTION;SUBCELLULAR LOCATION
    11. 11.
      "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1."
      Becamel C. , Figge A. , Poliak S. , Dumuis A. , Peles E. , Bockaert J. , Luebbert H. , Ullmer C.
      J. Biol. Chem.276:12974-12982(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MPDZ
    12. 12.
      "The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins."
      Becamel C. , Gavarini S. , Chanrion B. , Alonso G. , Galeotti N. , Dumuis A. , Bockaert J. , Marin P.
      J. Biol. Chem.279:20257-20266(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INADL; MPP3; PRDX6; DLG4; DLG1; CASK; APBA1 AND MAGI2;MUTAGENESIS OF GLY-463; ASN-465; CYS-470 AND VAL-471
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    14. 14.
      "Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells."
      Cussac D. , Boutet-Robinet E. , Ailhaud M.C. , Newman-Tancredi A. , Martel J.C. , Danty N. , Rauly-Lestienne I.
      Eur. J. Pharmacol.594:32-38(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRM2;FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    16. 16.
      "Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors."
      Knauer C.S. , Campbell J.E. , Chio C.L. , Fitzgerald L.W.
      Naunyn Schmiedebergs Arch. Pharmacol.379:461-471(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 17.
      "Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors."
      Albizu L. , Holloway T. , Gonzalez-Maeso J. , Sealfon S.C.
      Neuropharmacology61:770-777(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DRD2;FUNCTION;SUBCELLULAR LOCATION
    18. 18.
      "Serotonin receptors - from molecular biology to clinical applications."
      Pytliak M. , Vargova V. , Mechirova V. , Felsoci M.
      Physiol. Res.60:15-25(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    19. 19.
      "Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades."
      Delille H.K. , Becker J.M. , Burkhardt S. , Bleher B. , Terstappen G.C. , Schmidt M. , Meyer A.H. , Unger L. , Marek G.J. , Mezler M.
      Neuropharmacology62:2184-2191(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRM2;FUNCTION;SUBCELLULAR LOCATION
    20. 20.
      "Quantitative phosphoproteomics unravels biased phosphorylation of serotonin 2A receptor at Ser280 by hallucinogenic versus nonhallucinogenic agonists."
      Karaki S. , Becamel C. , Murat S. , Mannoury la Cour C. , Millan M.J. , Prezeau L. , Bockaert J. , Marin P. , Vandermoere F.
      Mol. Cell. Proteomics13:1273-1285(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-280;MUTAGENESIS OF SER-280
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      "Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia."
      Erdmann J. , Shimron-Abarbanell D. , Rietschel M. , Albus M. , Maier W. , Koerner J. , Bondy B. , Chen K. , Shih J.C. , Knapp M. , Propping P. , Noethen M.M.
      Hum. Genet.97:614-619(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASN-25 AND TYR-452
    22. 22.
      "Unified approach to the analysis of genetic variation in serotonergic pathways."
      Marshall S.E. , Bird T.G. , Hart K. , Welsh K.I.
      Am. J. Med. Genet.88:621-627(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASN-25 AND TYR-452
    23. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VAL-197; VAL-447 AND TYR-452
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
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