Protein name:
5-hydroxytryptamine receptor 2A (5-HT-2;5-HT-2A) ;
Alternative:
Serotonin receptor 2A ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2.
Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Localizes to the post-synaptic thickening of axo-dendritic synapses.
Protein Attributes:
50:
MDILCEENTS | LSSTTNSLMQ | LNDDTRLYSN | DFNSGEANTS | DAFNWTVDSE |
100:
NRTNLSCEGC | LSPSCLSLLH | LQEKNWSALL | TAVVIILTIA | GNILVIMAVS |
150:
LEKKLQNATN | YFLMSLAIAD | MLLGFLVMPV | SMLTILYGYR | WPLPSKLCAV |
200:
WIYLDVLFST | ASIMHLCAIS | LDRYVAIQNP | IHHSRFNSRT | KAFLKIIAVW |
250:
TISVGISMPI | PVFGLQDDSK | VFKEGSCLLA | DDNFVLIGSF | VSFFIPLTIM |
300:
VITYFLTIKS | LQKEATLCVS | DLGTRAKLAS | FSFLPQSSLS | SEKLFQRSIH |
350:
REPGSYTGRR | TMQSISNEQK | ACKVLGIVFF | LFVVMWCPFF | ITNIMAVICK |
400:
ESCNEDVIGA | LLNVFVWIGY | LSSAVNPLVY | TLFNKTYRSA | FSRYIQCQYK |
450:
ENKKPLQLIL | VNTIPALAYK | SSQLQMGQKK | NSKQDAKTTD | NDCSMVALGK |
471:
QHSEEASKDN | SDGVNEKVSC | V
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Dog
Mouse
Pig
Bovine
ELISA Kit for Human 5-HT-2
ELISA Kit for Human 5-HT-2
ELISA Kit for Human 5-HT-2
ELISA Kit for Human 5-HT-2
ELISA Kit for Human 5-HT-2
ELISA Kit for Human 5-HT-2
CLIA Kit for Human 5-HT-2
CLIA Kit for Human 5-HT-2
CLIA Kit for Human 5-HT-2
CLIA Kit for Human 5-HT-2
CLIA Kit for Human 5-HT-2
CLIA Kit for Human 5-HT-2
Polyclonal Antibody for Human 5-HT-2
Polyclonal Antibody for Human 5-HT-2
Polyclonal Antibody for Human 5-HT-2
Polyclonal Antibody for Human 5-HT-2
Polyclonal Antibody for Human 5-HT-2
Polyclonal Antibody for Human 5-HT-2
Monoclonal Antibody for Human 5-HT-2
Monoclonal Antibody for Human 5-HT-2
Monoclonal Antibody for Human 5-HT-2
Monoclonal Antibody for Human 5-HT-2
Monoclonal Antibody for Human 5-HT-2
Monoclonal Antibody for Human 5-HT-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Brain stem .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Platelet .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
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Nat. Genet.36:40-45(2004)
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Testis .
tissue :
Thalamus .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Lung .
9.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 9-464 (ISOFORM 1)
tissue :
Brain .
10.
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 105-218;FUNCTION;SUBCELLULAR LOCATION
11.
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Cited for : INTERACTION WITH MPDZ
12.
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Cited for : INTERACTION WITH INADL; MPP3; PRDX6; DLG4; DLG1; CASK; APBA1 AND MAGI2;MUTAGENESIS OF GLY-463; ASN-465; CYS-470 AND VAL-471
13.
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Cited for : REVIEW
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
15.
"Identification of a serotonin/glutamate receptor complex implicated in psychosis."
Gonzalez-Maeso J.
,
Ang R.L.
,
Yuen T.
,
Chan P.
,
Weisstaub N.V.
,
Lopez-Gimenez J.F.
,
Zhou M.
,
Okawa Y.
,
Callado L.F.
,
Milligan G.
,
Gingrich J.A.
,
Filizola M.
,
Meana J.J.
,
Sealfon S.C.
Nature452:93-97(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : INTERACTION WITH GRM2;FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
16.
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Cited for : FUNCTION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DRD2;FUNCTION;SUBCELLULAR LOCATION
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH GRM2;FUNCTION;SUBCELLULAR LOCATION
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-280;MUTAGENESIS OF SER-280
21.
"Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia."
Erdmann J.
,
Shimron-Abarbanell D.
,
Rietschel M.
,
Albus M.
,
Maier W.
,
Koerner J.
,
Bondy B.
,
Chen K.
,
Shih J.C.
,
Knapp M.
,
Propping P.
,
Noethen M.M.
Hum. Genet.97:614-619(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ASN-25 AND TYR-452
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ASN-25 AND TYR-452
23.
"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M.
,
Altshuler D.
,
Ireland J.
,
Sklar P.
,
Ardlie K.
,
Patil N.
,
Shaw N.
,
Lane C.R.
,
Lim E.P.
,
Kalyanaraman N.
,
Nemesh J.
,
Ziaugra L.
,
Friedland L.
,
Rolfe A.
,
Warrington J.
,
Lipshutz R.
,
Daley G.Q.
,
Lander E.S.
Nat. Genet.22:231-238(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS VAL-197; VAL-447 AND TYR-452
24.
Cargill M.
,
Altshuler D.
,
Ireland J.
,
Sklar P.
,
Ardlie K.
,
Patil N.
,
Shaw N.
,
Lane C.R.
,
Lim E.P.
,
Kalyanaraman N.
,
Nemesh J.
,
Ziaugra L.
,
Friedland L.
,
Rolfe A.
,
Warrington J.
,
Lipshutz R.
,
Daley G.Q.
,
Lander E.S.
Nat. Genet.23:373-373(1999)
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Cited for : ERRATUM