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Index > Protein center > HTR2C(Gene name) > Human
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  • HTR2C (Gene name),
  • 5-hydroxytryptamine receptor 2C (Protein name ),  5HT2C_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    HTR2C(HTR1C);
    Protein name:
    5-hydroxytryptamine receptor 2C(5-HT-2C;5-HT2C;5-HTR2C);
    Alternative:
    Serotonin receptor 2C;5-hydroxytryptamine receptor 1C(5-HT-1C;5-HT1C);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MPDZ. Interacts with ARRB2.
    Function:
    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    458
    Sequence:
    50:
    MVNLRNAVHS | FLVHLIGLLV | WQCDISVSPV | AAIVTDIFNT | SDGGRFKFPD | 
    100:
    GVQNWPALSI | VIIIIMTIGG | NILVIMAVSM | EKKLHNATNY | FLMSLAIADM | 
    150:
    LVGLLVMPLS | LLAILYDYVW | PLPRYLCPVW | ISLDVLFSTA | SIMHLCAISL | 
    200:
    DRYVAIRNPI | EHSRFNSRTK | AIMKIAIVWA | ISIGVSVPIP | VIGLRDEEKV | 
    250:
    FVNNTTCVLN | DPNFVLIGSF | VAFFIPLTIM | VITYCLTIYV | LRRQALMLLH | 
    300:
    GHTEEPPGLS | LDFLKCCKRN | TAEEENSANP | NQDQNARRRK | KKERRPRGTM | 
    350:
    QAINNERKAS | KVLGIVFFVF | LIMWCPFFIT | NILSVLCEKS | CNQKLMEKLL | 
    400:
    NVFVWIGYVC | SGINPLVYTL | FNKIYRRAFS | NYLRCNYKVE | KKPPVRQIPR | 
    450:
    VAATALSGRE | LNVNIYRHTN | EPVIEKASDN | EPGIEMQVEN | LELPVNPSSV | 
    458:
    VSERISSV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    SMR:
    Pfam:
    UniGene:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human 5-HT-2C
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    ELISA Kit for Human 5-HT-2C
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    ELISA Kit for Human 5-HT-2C
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    ELISA Kit for Human 5-HT-2C
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    E10285d
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    CLIA Kit for Human 5-HT-2C
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    U10285r
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    CLIA Kit for Human 5-HT-2C
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    U10285m
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    CLIA Kit for Human 5-HT-2C
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    U10285h
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    CLIA Kit for Human 5-HT-2C
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    U10285d
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    Packing:
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    Polyclonal Antibody for Human 5-HT-2C
    Polyclonal Antibody for Human 5-HT-2C
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    P10285Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human 5-HT-2C
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    P10285Rb-r
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    Polyclonal Antibody for Human 5-HT-2C
    Cat.:
    P10285Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human 5-HT-2C
    Monoclonal Antibody for Human 5-HT-2C
    Monoclonal Antibody for Human 5-HT-2C
    Monoclonal Antibody for Human 5-HT-2C
    Protein for Human 5-HT-2C
    Protein for Human 5-HT-2C
    Protein for Human 5-HT-2C
    Protein for Human 5-HT-2C

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    References
    1. 1.
      "Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes."
      Saltzman A.G. , Morse B. , Whitman M.M. , Ivanshchenko Y. , Jaye M. , Felder S.
      Biochem. Biophys. Res. Commun.181:1469-1478(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor."
      Stam N.J. , Vanderheyden P. , Van Alebeek C. , Klomp J. , De Boer T. , Van Delft A.M.L. , Olijve W.
      Eur. J. Pharmacol.269:339-348(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];FUNCTION;SUBCELLULAR LOCATION
      tissue: Hippocampus.
      tissue: Placenta.
    3. 3.
      "The human serotonin 5-HT2C receptor: complete cDNA, genomic structure, and alternatively spliced variant."
      Xie E. , Zhao L. , Levine A.J. , Shenk T. , Chang L.-S.
      Genomics35:551-561(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Brain.
    4. 4.
      "Identification and characterization of RNA editing events within the 5-HT2C receptor."
      Niswender C.M. , Sanders-Bush E. , Emeson R.B.
      Ann. N. Y. Acad. Sci.861:38-48(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);RNA EDITING OF POSITIONS 156; 158 AND 160
      tissue: Brain.
    5. 5.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III , Ikeda S.R. , Aronstam R.S.
      Submitted (2002-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Hippocampus.
    7. 7.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    9. 9.
      "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1."
      Becamel C. , Figge A. , Poliak S. , Dumuis A. , Peles E. , Bockaert J. , Luebbert H. , Ullmer C.
      J. Biol. Chem.276:12974-12982(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MPDZ;DOMAIN;MUTAGENESIS OF SER-456; SER-457 AND VAL-458;GLYCOSYLATION
    10. 10.
      "Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy."
      Schaerlinger B. , Hickel P. , Etienne N. , Guesnier L. , Maroteaux L.
      Br. J. Pharmacol.140:277-284(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    11. 11.
      "A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors."
      Marion S. , Oakley R.H. , Kim K.-M. , Caron M.G. , Barak L.S.
      J. Biol. Chem.281:2932-2938(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB2;MUTAGENESIS OF PRO-159
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    13. 13.
      "Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells."
      Cussac D. , Boutet-Robinet E. , Ailhaud M.C. , Newman-Tancredi A. , Martel J.C. , Danty N. , Rauly-Lestienne I.
      Eur. J. Pharmacol.594:32-38(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    14. 14.
      "Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors."
      Knauer C.S. , Campbell J.E. , Chio C.L. , Fitzgerald L.W.
      Naunyn Schmiedebergs Arch. Pharmacol.379:461-471(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    15. 15.
      "Serotonin receptors - from molecular biology to clinical applications."
      Pytliak M. , Vargova V. , Mechirova V. , Felsoci M.
      Physiol. Res.60:15-25(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    16. 16.
      "The N-terminal region of the human 5-HT(2)C receptor has as a cleavable signal peptide."
      Jahnsen J.A. , Uhlen S.
      Eur. J. Pharmacol.684:44-50(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SIGNAL SEQUENCE CLEAVAGE SITE;VARIANT SER-23
    17. 17.
      "Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C)."
      Lappalainen J. , Zhang L. , Dean M. , Oz M. , Ozaki N. , Yu D. , Virkkunen M. , Weight F. , Linnoila M. , Goldman D.
      Genomics27:274-279(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-23
    18. 18.
      "Association analysis between a Cys23Ser substitution polymorphism of the human 5-HT2c receptor gene and neuronal hyperexcitability."
      Samochowiec J. , Smolka M. , Winterer G. , Rommelspacher H. , Schmidt L.G. , Sander T.
      Am. J. Med. Genet.88:126-130(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-23
    19. 19.
      "Unified approach to the analysis of genetic variation in serotonergic pathways."
      Marshall S.E. , Bird T.G. , Hart K. , Welsh K.I.
      Am. J. Med. Genet.88:621-627(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-23
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-23
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
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