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Index > Protein center > A1CF(Gene name) > Human
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  • A1CF (Gene name),
  • APOBEC1 complementation factor (Protein name ),  A1CF_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    A1CF(ACF;ASP);
    Protein name:
    APOBEC1 complementation factor;
    Alternative:
    APOBEC1-stimulating protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Part of the apolipoprotein B mRNA editing complex with APOBEC1. Interacts with TNPO2; TNPO2 may be responsible for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2.
    Function:
    Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.
    Subcellular Location:
    Nucleus Endoplasmic reticulum Cytoplasm Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1.
    Protein Attributes:
    Sequence length:
    594
    Sequence:
    50:
    MESNHKSGDG | LSGTQKEAAL | RALVQRTGYS | LVQENGQRKY | GGPPPGWDAA | 
    100:
    PPERGCEIFI | GKLPRDLFED | ELIPLCEKIG | KIYEMRMMMD | FNGNNRGYAF | 
    150:
    VTFSNKVEAK | NAIKQLNNYE | IRNGRLLGVC | ASVDNCRLFV | GGIPKTKKRE | 
    200:
    EILSEMKKVT | EGVVDVIVYP | SAADKTKNRG | FAFVEYESHR | AAAMARRKLL | 
    250:
    PGRIQLWGHG | IAVDWAEPEV | EVDEDTMSSV | KILYVRNLML | STSEEMIEKE | 
    300:
    FNNIKPGAVE | RVKKIRDYAF | VHFSNREDAV | EAMKALNGKV | LDGSPIEVTL | 
    350:
    AKPVDKDSYV | RYTRGTGGRG | TMLQGEYTYS | LGQVYDPTTT | YLGAPVFYAP | 
    400:
    QTYAAIPSLH | FPATKGHLSN | RAIIRAPSVR | EIYMNVPVGA | AGVRGLGGRG | 
    450:
    YLAYTGLGRG | YQVKGDKRED | KLYDILPGME | LTPMNPVTLK | PQGIKLAPQI | 
    500:
    LEEICQKNNW | GQPVYQLHSA | IGQDQRQLFL | YKITIPALAS | QNPAIHPFTP | 
    550:
    PKLSAFVDEA | KTYAAEYTLQ | TLGIPTDGGD | GTMATAAAAA | TAFPGYAVPN | 
    594:
    ATAPVSAAQL | KQAVTLGQDL | AAYTTYEVYP | TFAVTARGDG | YGTF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    SMR:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human APOBEC1 complementation factor
    ELISA Kit for Human APOBEC1 complementation factor
    ELISA Kit for Human APOBEC1 complementation factor
    CLIA Kit for Human APOBEC1 complementation factor
    CLIA Kit for Human APOBEC1 complementation factor
    CLIA Kit for Human APOBEC1 complementation factor
    Polyclonal Antibody for Human APOBEC1 complementation factor
    Polyclonal Antibody for Human APOBEC1 complementation factor
    Polyclonal Antibody for Human APOBEC1 complementation factor
    Monoclonal Antibody for Human APOBEC1 complementation factor
    Monoclonal Antibody for Human APOBEC1 complementation factor
    Monoclonal Antibody for Human APOBEC1 complementation factor
    Protein for Human APOBEC1 complementation factor
    Protein for Human APOBEC1 complementation factor
    Protein for Human APOBEC1 complementation factor

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex."
      Lellek H. , Kirsten R. , Diehl I. , Apostel F. , Buck F. , Greeve J.
      J. Biol. Chem.275:19848-19856(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;INTERACTION WITH APOBEC1
      tissue: Liver.
      tissue: Small intestine.
    2. 2.
      "Molecular cloning of APOBEC-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA."
      Mehta A. , Kinter M.T. , Sherman N.E. , Driscoll D.M.
      Mol. Cell. Biol.20:1846-1854(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INTERACTION WITH APOBEC1;TISSUE SPECIFICITY
    3. 3.
      "Human APOBEC-1 complementation factor related protein."
      Sowden M.P. , Smith H.C.
      Submitted (2000-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3)
      tissue: Liver.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4)
      tissue: Small intestine.
    5. 5.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)
    8. 8.
      "Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing."
      Blanc V. , Navaratnam N. , Henderson J.O. , Anant S. , Kennedy S. , Jarmuz A. , Scott J. , Davidson N.O.
      J. Biol. Chem.276:10272-10283(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYNCRIP
    9. 9.
      "Isolation, characterization and developmental regulation of the human apobec-1 complementation factor (ACF) gene."
      Henderson J.O. , Blanc V. , Davidson N.O.
      Biochim. Biophys. Acta1522:22-30(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GENE STRUCTURE;ALTERNATIVE SPLICING
    10. 10.
      "Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing."
      Mehta A. , Driscoll D.M.
      RNA8:69-82(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RNA-BINDING DOMAIN;MUTAGENESIS OF PHE-59; PHE-100; PHE-139; PHE-183; TYR-234 AND PHE-270
    11. 11.
      "The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay."
      Chester A. , Somasekaram A. , Tzimina M. , Jarmuz A. , Gisbourne J. , O'Keefe R. , Scott J. , Navaratnam N.
      EMBO J.22:3971-3982(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    12. 12.
      "A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling."
      Blanc V. , Kennedy S. , Davidson N.O.
      J. Biol. Chem.278:41198-41204(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEAR LOCALIZATION SIGNAL;INTERACTION WITH TNPO2
    13. 13.
      "Solution structure of the RNA recognition motif of human APOBEC-1 complementation factor, ACF."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2005-11) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 223-308
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