A1cf ELISA Kit for Mouse(Mus musculus) | EIAab.comA1cf ELISA Kit for Mouse(Mus musculus)

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A1cf (Gene name),

APOBEC1 complementation factor (Protein name ), A1CF_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

A1cf(Acf;Asp);

Protein name:

APOBEC1 complementation factor;

Alternative:

APOBEC1-stimulating protein;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Part of the apolipoprotein B mRNA editing complex with APOBEC1. Interacts with TNPO2; TNPO2 may be responsible for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2.

Function:

Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also seems to protect the edited APOB mRNA from nonsense-mediated decay.

Subcellular Location:

Nucleus Endoplasmic reticulum Cytoplasm Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum. Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1.

Protein Attributes:

Sequence length:

595

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

595:

SATAPVSTAQ | LKQAVTLGQD | LAAYTTYEVY | PTFALTTRGD | AYGTF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q5YD48

KEGG:

mmu:69865

UniGene:

Mm.87538

Pfam:

PF00076

String:

Q5YD48

Uniprot:

Q5YD48

FOR

ELISA Kit for Mouse APOBEC1 complementation factor

CLIA Kit for Mouse APOBEC1 complementation factor

Polyclonal Antibody for Mouse APOBEC1 complementation factor

Monoclonal Antibody for Mouse APOBEC1 complementation factor

Protein for Mouse APOBEC1 complementation factor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Gene structure and expression of the mouse APOBEC-1 complementation factor: multiple transcriptional initiation sites and a spliced variant with a premature stop translation codon."
Duer S. , Krause K. , Pluntke N. , Greeve J.
Biochim. Biophys. Acta1680:11-23(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);TISSUE SPECIFICITY
strain: BALB/c.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Liver.
4.

"Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality."
Blanc V. , Henderson J.O. , Newberry E.P. , Kennedy S. , Luo J. , Davidson N.O.
Mol. Cell. Biol.25:7260-7269(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE

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