AAK1 ELISA Kit for Pig(Sus scrofa) | EIAab.comAAK1 ELISA Kit for Pig(Sus scrofa)

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AAK1 (Gene name),

AP2-associated protein kinase 1 (Protein name ), AAK1_PIG from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

AAK1;

Protein name:

AP2-associated protein kinase 1;

Alternative:

Adaptor-associated kinase 1;

Organism:

Pig (Sus scrofa).

General Annotation

Sub Unit:

Interacts with alpha-adaptin, AP-2, clathrin, NUMB and EPS15. Interacts with membrane-bound activated NOTCH1 but not with the inactive full-length form of NOTCH1. Preferentially interacts with monoubiquitinated activated NOTCH1 compared to the non-ubiquitinated form.

Function:

Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.

Subcellular Location:

Cell membrane Peripheral membrane protein Membrane clathrin-coated pit Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells.

Protein Attributes:

Sequence length:

968

Sequence:

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968:

SLPNLARSLL | LVDQLIDL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00069

Uniprot:

F1SPM8

FOR

ELISA Kit for Pig AP2-associated protein kinase 1

CLIA Kit for Pig AP2-associated protein kinase 1

Polyclonal Antibody for Pig AP2-associated protein kinase 1

Monoclonal Antibody for Pig AP2-associated protein kinase 1

Protein for Pig AP2-associated protein kinase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

Porcine genome sequencing project
Submitted (2009-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
2.

"Porcine ESTs using full-length-enriched cDNA libraries."
Uenishi H. , Morozumi T. , Toki D. , Eguchi-Ogawa T. , Tanaka-Matsuda M.
Submitted (2010-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-54
3.

"Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals."
Ricotta D. , Conner S.D. , Schmid S.L. , von Figura K. , Honing S.
J. Cell Biol.156:791-795(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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