5'-AMP-activated protein kinase subunit beta-1 (Protein name
), AAKB1_MOUSE from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
Prkab1;
Protein name:
5'-AMP-activated protein kinase subunit beta-1(AMPK subunit beta-1;AMPKb);
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
Function:
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
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Precision
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Recovery
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Linearity
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References
1.
"5'-AMP-activated protein kinase subunit beta interacts with the p42 subunit of translation initiation factor eIF3." Valentijn L.J.
,
Hoff E.I.
,
Baas F.
Submitted (1998-11) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-201;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]