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Index > Protein center > Prkab1(Gene name) > Mouse
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  • Prkab1 (Gene name),
  • 5'-AMP-activated protein kinase subunit beta-1 (Protein name ),  AAKB1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Prkab1;
    Protein name:
    5'-AMP-activated protein kinase subunit beta-1(AMPK subunit beta-1;AMPKb);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
    Function:
    Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    270
    Sequence:
    50:
    MGNTSSERAA | LERQAGHKTP | RRDSSGGAKD | GDRPKILMDS | PEDADIFHSE | 
    100:
    EIKAPEKEEF | LAWQHDLEAN | DKAPAQARPT | VFRWTGGGKE | VYLSGSFNNW | 
    150:
    SKLPLTRSQN | NFVAILDLPE | GEHQYKFFVD | GQWTHDPSEP | IVTSQLGTVN | 
    200:
    NIIQVKKTDF | EVFDALMVDS | QKCSDVSELS | SSPPGPYHQE | PYMSKPEERF | 
    250:
    KAPPILPPHL | LQVILNKDTG | ISCDPALLPE | PNHVMLNHLY | ALSIKDGVMV | 
    270:
    LSATHRYKKK | YVTTLLYKPI | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    KEGG:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse AMPK subunit beta-1
    Cat.:
    E1671h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse AMPK subunit beta-1
    Cat.:
    E1671r
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    Packing:
    96T
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    ELISA Kit for Mouse AMPK subunit beta-1
    MSDS:
    Please sign in first.
    ELISA Kit for Mouse AMPK subunit beta-1
    Cat.:
    E1671b
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    MSDS:
    Please sign in first.
    Packing:
    96T
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    ELISA Kit for Mouse AMPK subunit beta-1
    Cat.:
    E1671m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse AMPK subunit beta-1
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse AMPK subunit beta-1
    Cat.:
    U1671h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse AMPK subunit beta-1
    Cat.:
    U1671m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse AMPK subunit beta-1
    Cat.:
    U1671r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse AMPK subunit beta-1
    Cat.:
    U1671b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse AMPK subunit beta-1
    Cat.:
    P1671Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse AMPK subunit beta-1
    Cat.:
    P1671Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse AMPK subunit beta-1
    Polyclonal Antibody for Mouse AMPK subunit beta-1
    Cat.:
    P1671Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse AMPK subunit beta-1
    Monoclonal Antibody for Mouse AMPK subunit beta-1
    Monoclonal Antibody for Mouse AMPK subunit beta-1
    Monoclonal Antibody for Mouse AMPK subunit beta-1
    Monoclonal Antibody for Mouse AMPK subunit beta-1
    Monoclonal Antibody for Mouse AMPK subunit beta-1
    Protein for Mouse AMPK subunit beta-1
    Protein for Mouse AMPK subunit beta-1
    Protein for Mouse AMPK subunit beta-1
    Protein for Mouse AMPK subunit beta-1
    Protein for Mouse AMPK subunit beta-1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "5'-AMP-activated protein kinase subunit beta interacts with the p42 subunit of translation initiation factor eIF3."
      Valentijn L.J. , Hoff E.I. , Baas F.
      Submitted (1998-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: CD-1.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    4. 4.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    5. 5.
      "Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop."
      Loffler A.S. , Alers S. , Dieterle A.M. , Keppeler H. , Franz-Wachtel M. , Kundu M. , Campbell D.G. , Wesselborg S. , Alessi D.R. , Stork B.
      Autophagy7:696-706(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY ULK1
    6. 6.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-201;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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