Prkab2 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comPrkab2 ELISA Kit for Rat(Rattus norvegicus)

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Prkab2 (Gene name),

5'-AMP-activated protein kinase subunit beta-2 (Protein name ), AAKB2_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Prkab2;

Protein name:

5'-AMP-activated protein kinase subunit beta-2(AMPK subunit beta-2);

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3).

Function:

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

271

Sequence:

50:

100:

150:

200:

250:

271:

VLSATHRYKK | KYVTTLLYKP | I

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF04739

SMR:

Q9QZH4

KEGG:

rno:64562

UniGene:

Rn.207202

String:

Q9QZH4

Uniprot:

Q9QZH4

FOR

ELISA Kit for Rat AMPK subunit beta-2

CLIA Kit for Rat AMPK subunit beta-2

Polyclonal Antibody for Rat AMPK subunit beta-2

Monoclonal Antibody for Rat AMPK subunit beta-2

Protein for Rat AMPK subunit beta-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle."
Chen Z. , Heierhorst J. , Mann R.J. , Mitchelhill K.I. , Michell B.J. , Witters L.A. , Lynch G.S. , Kemp B.E. , Stapleton D.
FEBS Lett.460:343-348(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PHOSPHORYLATION AT SER-183
strain: Sprague-Dawley.
tissue: Skeletal muscle.
2.

"Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop."
Loffler A.S. , Alers S. , Dieterle A.M. , Keppeler H. , Franz-Wachtel M. , Kundu M. , Campbell D.G. , Wesselborg S. , Alessi D.R. , Stork B.
Autophagy7:696-706(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY ULK1 AND ULK2;PHOSPHORYLATION AT SER-38; THR-39; SER-68 AND SER-173

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