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Index > Protein center > PRKAG2(Gene name) > Human
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  • PRKAG2 (Gene name),
  • 5'-AMP-activated protein kinase subunit gamma-2 (Protein name ),  AAKG2_HUMAN from NCBI database.
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  • Gene name:
    PRKAG2;
    Protein name:
    5'-AMP-activated protein kinase subunit gamma-2(AMPK gamma2;AMPK subunit gamma-2);
    Alternative:
    H91620p;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
    Function:
    AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    569
    Sequence:
    50:
    MGSAVMDTKK | KKDVSSPGGS | GGKKNASQKR | RSLRVHIPDL | SSFAMPLLDG | 
    100:
    DLEGSGKHSS | RKVDSPFGPG | SPSKGFFSRG | PQPRPSSPMS | APVRPKTSPG | 
    150:
    SPKTVFPFSY | QESPPRSPRR | MSFSGIFRSS | SKESSPNSNP | ATSPGGIRFF | 
    200:
    SRSRKTSGLS | SSPSTPTQVT | KQHTFPLESY | KHEPERLENR | IYASSSPPDT | 
    250:
    GQRFCPSSFQ | SPTRPPLASP | THYAPSKAAA | LAAALGPAEA | GMLEKLEFED | 
    300:
    EAVEDSESGV | YMRFMRSHKC | YDIVPTSSKL | VVFDTTLQVK | KAFFALVANG | 
    350:
    VRAAPLWESK | KQSFVGMLTI | TDFINILHRY | YKSPMVQIYE | LEEHKIETWR | 
    400:
    ELYLQETFKP | LVNISPDASL | FDAVYSLIKN | KIHRLPVIDP | ISGNALYILT | 
    450:
    HKRILKFLQL | FMSDMPKPAF | MKQNLDELGI | GTYHNIAFIH | PDTPIIKALN | 
    500:
    IFVERRISAL | PVVDESGKVV | DIYSKFDVIN | LAAEKTYNNL | DITVTQALQH | 
    550:
    RSQYFEGVVK | CNKLEILETI | VDRIVRAEVH | RLVVVNEADS | IVGIISLSDI | 
    569:
    LQALILTPAG | AKQKETETE
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    String:
    KEGG:
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human AMPK gamma2
    ELISA Kit for Human AMPK gamma2
    CLIA Kit for Human AMPK gamma2
    CLIA Kit for Human AMPK gamma2
    Polyclonal Antibody for Human AMPK gamma2
    Polyclonal Antibody for Human AMPK gamma2
    Monoclonal Antibody for Human AMPK gamma2
    Monoclonal Antibody for Human AMPK gamma2
    Protein for Human AMPK gamma2
    Protein for Human AMPK gamma2

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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Human homolog of AMPK gamma-1 chain."
      Hattori A. , Seki N. , Hayashi A. , Kozuma S. , Muramatsu M. , Saito T.
      Submitted (1999-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)
    2. 2.
      "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding."
      Cheung P.C.F. , Salt I.P. , Davies S.P. , Hardie D.G. , Carling D.
      Biochem. J.346:659-669(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)
    3. 3.
      "Molecular cloning, genomic organization, and mapping of PRKAG2, a heart abundant gamma-2 subunit of 5'-AMP-activated protein kinase, to human chromosome 7q36."
      Lang T.M. , Yu L. , Qiang T. , Jiang J.M. , Chen Z. , Xin Y.R. , Liu G.Y. , Zhao S.
      Genomics70:258-263(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B)
      tissue: Placenta.
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B)
    6. 6.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS B AND C)
      tissue: Brain.
      tissue: Liver.
    8. 8.
      "CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations."
      Scott J.W. , Hawley S.A. , Green K.A. , Anis M. , Stewart G. , Scullion G.A. , Norman D.G. , Hardie D.G.
      J. Clin. Invest.113:274-284(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN CBS;AMP-BINDING;ATP-BINDING;CHARACTERIZATION OF VARIANTS WPWS GLN-302; ARG-383 AND ASN-400;CHARACTERIZATION OF VARIANT WPWS GLY-531;FUNCTION
    9. 9.
      "Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit."
      Scott J.W. , Ross F.A. , Liu J.K. , Hardie D.G.
      EMBO J.26:806-815(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN AMPK PSEUDOSUBSTRATE;MUTAGENESIS OF VAL-387
    10. 10.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop."
      Loffler A.S. , Alers S. , Dieterle A.M. , Keppeler H. , Franz-Wachtel M. , Kundu M. , Campbell D.G. , Wesselborg S. , Alessi D.R. , Stork B.
      Autophagy7:696-706(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY ULK1
    14. 14.
      "AMP-activated protein kinase in metabolic control and insulin signaling."
      Towler M.C. , Hardie D.G.
      Circ. Res.100:328-341(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    15. 15.
      "AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy."
      Hardie D.G.
      Nat. Rev. Mol. Cell Biol.8:774-785(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    16. 16.
      "Novel PRKAG2 mutation responsible for the genetic syndrome of ventricular preexcitation and conduction system disease with childhood onset and absence of cardiac hypertrophy."
      Gollob M.H. , Seger J.J. , Gollob T.N. , Tapscott T. , Gonzales O. , Bachinski L. , Roberts R.
      Circulation104:3030-3033(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT WPWS GLY-531
    17. 17.
      "Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis."
      Blair E. , Redwood C. , Ashrafian H. , Oliveira M. , Broxholme J. , Kerr B. , Salmon A. , Oestman-Smith I. , Watkins H.
      Hum. Mol. Genet.10:1215-1220(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMH6 LEU-350 INS AND ARG-383
    18. 18.
      "Identification of a gene responsible for familial Wolff-Parkinson-White syndrome."
      Gollob M.H. , Green M.S. , Tang A.S.-L. , Gollob T. , Karibe A. , Al Sayegh A.H. , Ahmad F. , Lozado R. , Shah G. , Fananapazir L. , Bachinski L.L. , Roberts R.
      N. Engl. J. Med.344:1823-1831(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT WPWS GLN-302
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    21. 21.
      "Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy."
      Arad M. , Benson D.W. , Perez-Atayde A.R. , McKenna W.J. , Sparks E.A. , Kanter R.J. , McGarry K. , Seidman J.G. , Seidman C.E.
      J. Clin. Invest.109:357-362(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMH6 GLN-302; ASN-400 AND ILE-488
    22. 22.
      "Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency."
      Burwinkel B. , Scott J.W. , Buehrer C. , van Landeghem F.K.H. , Cox G.F. , Wilson C.J. , Grahame Hardie D. , Kilimann M.W.
      Am. J. Hum. Genet.76:1034-1049(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GSDH GLN-531;CHARACTERIZATION OF VARIANT GSDH GLN-531
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