Protein name:
5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2;AMPK subunit gamma-2) ;
Alternative:
H91620p ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
Function:
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
Subcellular Location:
N/A
Protein Attributes:
50:
MGSAVMDTKK | KKDVSSPGGS | GGKKNASQKR | RSLRVHIPDL | SSFAMPLLDG |
100:
DLEGSGKHSS | RKVDSPFGPG | SPSKGFFSRG | PQPRPSSPMS | APVRPKTSPG |
150:
SPKTVFPFSY | QESPPRSPRR | MSFSGIFRSS | SKESSPNSNP | ATSPGGIRFF |
200:
SRSRKTSGLS | SSPSTPTQVT | KQHTFPLESY | KHEPERLENR | IYASSSPPDT |
250:
GQRFCPSSFQ | SPTRPPLASP | THYAPSKAAA | LAAALGPAEA | GMLEKLEFED |
300:
EAVEDSESGV | YMRFMRSHKC | YDIVPTSSKL | VVFDTTLQVK | KAFFALVANG |
350:
VRAAPLWESK | KQSFVGMLTI | TDFINILHRY | YKSPMVQIYE | LEEHKIETWR |
400:
ELYLQETFKP | LVNISPDASL | FDAVYSLIKN | KIHRLPVIDP | ISGNALYILT |
450:
HKRILKFLQL | FMSDMPKPAF | MKQNLDELGI | GTYHNIAFIH | PDTPIIKALN |
500:
IFVERRISAL | PVVDESGKVV | DIYSKFDVIN | LAAEKTYNNL | DITVTQALQH |
550:
RSQYFEGVVK | CNKLEILETI | VDRIVRAEVH | RLVVVNEADS | IVGIISLSDI |
569:
LQALILTPAG | AKQKETETE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human AMPK gamma2
ELISA Kit for Human AMPK gamma2
CLIA Kit for Human AMPK gamma2
CLIA Kit for Human AMPK gamma2
Polyclonal Antibody for Human AMPK gamma2
Polyclonal Antibody for Human AMPK gamma2
Monoclonal Antibody for Human AMPK gamma2
Monoclonal Antibody for Human AMPK gamma2
Protein for Human AMPK gamma2
Protein for Human AMPK gamma2
R&D Technical Data
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Precision
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Recovery
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Linearity
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS B AND C)
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Brain .
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Liver .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DOMAIN CBS;AMP-BINDING;ATP-BINDING;CHARACTERIZATION OF VARIANTS WPWS GLN-302; ARG-383 AND ASN-400;CHARACTERIZATION OF VARIANT WPWS GLY-531;FUNCTION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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20.
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Tang A.S.-L.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CMH6 GLN-302; ASN-400 AND ILE-488
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT GSDH GLN-531;CHARACTERIZATION OF VARIANT GSDH GLN-531