Gene name:
AATF (HSPC277;CHE1;DED) ;
Protein name:
Protein AATF ;
Alternative:
Rb-binding protein Che-1 ;Apoptosis-antagonizing transcription factor ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT.
Function:
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Subcellular Location:
Nucleus
nucleolus
Protein Attributes:
50:
MAGPQPLALQ | LEQLLNPRPS | EADPEADPEE | ATAARVIDRF | DEGEDGEGDF |
100:
LVVGSIRKLA | SASLLDTDKR | YCGKTTSRKA | WNEDHWEQTL | PGSSDEEISD |
150:
EEGSGDEDSE | GLGLEEYDED | DLGAAEEQEC | GDHRESKKSR | SHSAKTPGFS |
200:
VQSISDFEKF | TKGMDDLGSS | EEEEDEESGM | EEGDDAEDSQ | GESEEDRAGD |
250:
RNSEDDGVVM | TFSSVKVSEE | VEKGRAVKNQ | IALWDQLLEG | RIKLQKALLT |
300:
TNQLPQPDVF | PLFKDKGGPE | FSSALKNSHK | ALKALLRSLV | GLQEELLFQY |
350:
PDTRYLVDGT | KPNAGSEEIS | SEDDELVEEK | KQQRRRVPAK | RKLEMEDYPS |
400:
FMAKRFADFT | VYRNRTLQKW | HDKTKLASGK | LGKGFGAFER | SILTQIDHIL |
450:
MDKERLLRRT | QTKRSVYRVL | GKPEPAAQPV | PESLPGEPEI | LPQAPANAHL |
500:
KDLDEEIFDD | DDFYHQLLRE | LIERKTSSLD | PNDQVAMGRQ | WLAIQKLRSK |
550:
IHKKVDRKAS | KGRKLRFHVL | SKLLSFMAPI | DHTTMNDDAR | TELYRSLFGQ |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Chicken
Rat
Mouse
Human
ELISA Kit for Human Protein AATF
ELISA Kit for Human Protein AATF
ELISA Kit for Human Protein AATF
ELISA Kit for Human Protein AATF
CLIA Kit for Human Protein AATF
CLIA Kit for Human Protein AATF
CLIA Kit for Human Protein AATF
CLIA Kit for Human Protein AATF
Polyclonal Antibody for Human Protein AATF
Polyclonal Antibody for Human Protein AATF
Polyclonal Antibody for Human Protein AATF
Polyclonal Antibody for Human Protein AATF
Monoclonal Antibody for Human Protein AATF
Monoclonal Antibody for Human Protein AATF
Monoclonal Antibody for Human Protein AATF
Monoclonal Antibody for Human Protein AATF
Protein for Human Protein AATF
Protein for Human Protein AATF
Protein for Human Protein AATF
Protein for Human Protein AATF
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH POLR2J AND RB1;TISSUE SPECIFICITY
tissue :
Skeletal muscle .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Testis .
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Skin .
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Submitted (1999-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 361-560
tissue :
Umbilical cord blood .
8.
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Cancer Cell2:387-399(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PHOSPHORYLATION AT THE G1/S TRANSITION;INTERACTION WITH RB1; RBL1 AND RBL2
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
10.
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PubMed ]
[
Europe PMC ]
[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH SP1
11.
"Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis."
Barbato C.
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Mol. Cell. Neurosci.24:1038-1050(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MAPT
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH PAWR
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316; SER-320 AND SER-321;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316; SER-320 AND SER-321;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
17.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
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Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; SER-316; SER-320 AND SER-321;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
18.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; SER-316; SER-320 AND SER-321;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]