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Index > Protein center > AATF(Gene name) > Human
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  • AATF (Gene name),
  • Protein AATF (Protein name ),  AATF_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    AATF(HSPC277;CHE1;DED);
    Protein name:
    Protein AATF;
    Alternative:
    Rb-binding protein Che-1;Apoptosis-antagonizing transcription factor;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT.
    Function:
    May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
    Subcellular Location:
    Nucleus nucleolus
    Protein Attributes:
    Sequence length:
    560
    Sequence:
    50:
    MAGPQPLALQ | LEQLLNPRPS | EADPEADPEE | ATAARVIDRF | DEGEDGEGDF | 
    100:
    LVVGSIRKLA | SASLLDTDKR | YCGKTTSRKA | WNEDHWEQTL | PGSSDEEISD | 
    150:
    EEGSGDEDSE | GLGLEEYDED | DLGAAEEQEC | GDHRESKKSR | SHSAKTPGFS | 
    200:
    VQSISDFEKF | TKGMDDLGSS | EEEEDEESGM | EEGDDAEDSQ | GESEEDRAGD | 
    250:
    RNSEDDGVVM | TFSSVKVSEE | VEKGRAVKNQ | IALWDQLLEG | RIKLQKALLT | 
    300:
    TNQLPQPDVF | PLFKDKGGPE | FSSALKNSHK | ALKALLRSLV | GLQEELLFQY | 
    350:
    PDTRYLVDGT | KPNAGSEEIS | SEDDELVEEK | KQQRRRVPAK | RKLEMEDYPS | 
    400:
    FMAKRFADFT | VYRNRTLQKW | HDKTKLASGK | LGKGFGAFER | SILTQIDHIL | 
    450:
    MDKERLLRRT | QTKRSVYRVL | GKPEPAAQPV | PESLPGEPEI | LPQAPANAHL | 
    500:
    KDLDEEIFDD | DDFYHQLLRE | LIERKTSSLD | PNDQVAMGRQ | WLAIQKLRSK | 
    550:
    IHKKVDRKAS | KGRKLRFHVL | SKLLSFMAPI | DHTTMNDDAR | TELYRSLFGQ | 
    560:
    LHPPDEGHGD | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    MIM:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein AATF
    ELISA Kit for Human Protein AATF
    ELISA Kit for Human Protein AATF
    ELISA Kit for Human Protein AATF
    CLIA Kit for Human Protein AATF
    CLIA Kit for Human Protein AATF
    CLIA Kit for Human Protein AATF
    CLIA Kit for Human Protein AATF
    Polyclonal Antibody for Human Protein AATF
    Polyclonal Antibody for Human Protein AATF
    Polyclonal Antibody for Human Protein AATF
    Polyclonal Antibody for Human Protein AATF
    Monoclonal Antibody for Human Protein AATF
    Monoclonal Antibody for Human Protein AATF
    Monoclonal Antibody for Human Protein AATF
    Monoclonal Antibody for Human Protein AATF
    Protein for Human Protein AATF
    Protein for Human Protein AATF
    Protein for Human Protein AATF
    Protein for Human Protein AATF

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification of novel transcription factor-like gene from human intestinal cells."
      Lindfors K. , Halttunen T. , Huotari P. , Nupponen N. , Vihinen M. , Visakorpi T. , Maki M. , Kainulainen H.
      Biochem. Biophys. Res. Commun.276:660-666(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
    2. 2.
      "Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb."
      Fanciulli M. , Bruno T. , Di Padova M. , De Angelis R. , Iezzi S. , Iacobini C. , Floridi A. , Passananti C.
      FASEB J.14:904-912(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH POLR2J AND RB1;TISSUE SPECIFICITY
      tissue: Skeletal muscle.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    4. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Skin.
    6. 7.
      "Human partial CDS from CD34+ stem cells."
      Ye M. , Zhang Q.-H. , Zhou J. , Shen Y. , Wu X.-Y. , Guan Z.Q. , Wang L. , Fan H.-Y. , Mao Y.-F. , Dai M. , Huang Q.-H. , Chen S.-J. , Chen Z.
      Submitted (1999-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 361-560
      tissue: Umbilical cord blood.
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT THE G1/S TRANSITION;INTERACTION WITH RB1; RBL1 AND RBL2
    8. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 10.
      "Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter."
      Di Padova M. , Bruno T. , De Nicola F. , Iezzi S. , D'Angelo C. , Gallo R. , Nicosia D. , Corbi N. , Biroccio A. , Floridi A. , Passananti C. , Fanciulli M.
      J. Biol. Chem.278:36496-36504(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SP1
    10. 11.
      "Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis."
      Barbato C. , Corbi N. , Canu N. , Fanciulli M. , Serafino A. , Ciotti M. , Libri V. , Bruno T. , Amadoro G. , De Angelis R. , Calissano P. , Passananti C.
      Mol. Cell. Neurosci.24:1038-1050(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPT
    11. 12.
      "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4."
      Guo Q. , Xie J.
      J. Biol. Chem.279:4596-4603(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PAWR
    12. 13.
      "AATF protects neural cells against oxidative damage induced by amyloid beta-peptide."
      Xie J. , Guo Q.
      Neurobiol. Dis.16:150-157(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316; SER-320 AND SER-321;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 15.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    15. 16.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316; SER-320 AND SER-321;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    16. 17.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; SER-316; SER-320 AND SER-321;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 18.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; SER-316; SER-320 AND SER-321;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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