APBB1IP ELISA Kit for Human(Homo sapiens) | EIAab.comAPBB1IP ELISA Kit for Human(Homo sapiens)

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APBB1IP (Gene name),

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (Protein name ), AB1IP_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

APBB1IP(PREL1;RARP1;RIAM);

Protein name:

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein;

Alternative:

Proline-rich EVH1 ligand 1(PREL-1);APBB1-interacting protein 1;Rap1-GTP-interacting adapter molecule(RIAM);Proline-rich protein 73;Retinoic acid-responsive proline-rich protein 1(RARP-1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1, VASP and ENAH.

Function:

Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.

Subcellular Location:

Cell membrane Peripheral membrane protein Cell projection lamellipodium Cell junction focal adhesion Cytoplasm cytoskeleton Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases.

Protein Attributes:

Sequence length:

666

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

666:

MSDLMKALQK | KRGNVS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q7Z5R6

UniGene:

Hs.310421

KEGG:

hsa:54518

Pfam:

PF00169

MIM:

609036

String:

Q7Z5R6

STRING:

9606.ENSP00000365411

Uniprot:

Q7Z5R6

FOR

ELISA Kit for Human Amyloid beta A4 precursor protein-binding family B member 1-interacting protein

CLIA Kit for Human Amyloid beta A4 precursor protein-binding family B member 1-interacting protein

Polyclonal Antibody for Human Amyloid beta A4 precursor protein-binding family B member 1-interacting protein

Monoclonal Antibody for Human Amyloid beta A4 precursor protein-binding family B member 1-interacting protein

Protein for Human Amyloid beta A4 precursor protein-binding family B member 1-interacting protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells."
Inagaki T. , Suzuki S. , Miyamoto T. , Takeda T. , Yamashita K. , Komatsu A. , Yamauchi K. , Hashizume K.
J. Biol. Chem.278:51685-51692(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
tissue: Thymus.
2.

"RIAM, an Ena/VASP and profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion."
Lafuente E.M. , van Puijenbroek A.A. , Krause M. , Carman C.V. , Freeman G.J. , Berezovskaya A. , Constantine E. , Springer T.A. , Gertler F.B. , Boussiotis V.A.
Dev. Cell7:585-595(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH RAP1A; PFN1; VASP AND ENAH
tissue: T-cell.
3.

"PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins."
Jenzora A. , Behrendt B. , Small J.V. , Wehland J. , Stradal T.E.
FEBS Lett.579:455-463(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Cervix carcinoma.
4.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Blood.
7.

"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
Carrascal M. , Ovelleiro D. , Casas V. , Gay M. , Abian J.
J. Proteome Res.7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: T-cell.
8.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55 AND SER-526;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
9.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover."
Goult B.T. , Zacharchenko T. , Bate N. , Tsang R. , Hey F. , Gingras A.R. , Elliott P.R. , Roberts G.C. , Ballestrem C. , Critchley D.R. , Barsukov I.L.
J. Biol. Chem.288:8238-8249(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1-31 IN COMPLEX WITH VCL;INTERACTION WITH VCL AND TLN1

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