Protein name:
Probable DNA dC->dU-editing enzyme APOBEC-3A (A3A) ;
Alternative:
Phorbolin-1 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Single-stranded DNA cytidine deaminase involved in foreign DNA clearance. May trigger C-to-U hypermutation in exogenous DNA leading to its degradation. Provides cellular innate resistance to a specific panel of genetic invaders including endogenous retroelements and a subset of viruses. May have a preference for cytidines in a C-C sequence context. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Subcellular Location:
Nucleus
Cytoplasm
Protein Attributes:
50:
MEASPASGPR | HLMDPHIFTS | NFNNGIGRHK | TYLCYEVERL | DNGTSVKMDQ |
100:
HRGFLHNQAK | NLLCGFYGRH | AELRFLDLVP | SLQLDPAQIY | RVTWFISWSP |
150:
CFSWGCAGEV | RAFLQENTHV | RLRIFAARIY | DYDPLYKEAL | QMLRDAGAQV |
199:
SIMTYDEFKH | CWDTFVDHQG | CPFQPWDGLD | EHSQALSGRL | RAILQNQGN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Polyclonal Antibody for Human A3A
Monoclonal Antibody for Human A3A
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
"Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1."
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Celis J.E.
J. Invest. Dermatol.113:162-169(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 19-27; 31-35; 53-60; 112-123; 129-137 AND 192-198;FUNCTION
tissue :
Keratinocyte .
2.
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Genome Biol.5:R84.1-R84.11(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
3.
"The DNA sequence of human chromosome 22."
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more...
Nature402:489-495(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 53-60; 112-121 AND 129-137
tissue :
Keratinocyte .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GENE FAMILY ORGANIZATION;TISSUE SPECIFICITY
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON APOBEC FAMILIES
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN HOST DEFENSE
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN HOST DEFENSE;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;MUTAGENESIS OF HIS-70; GLU-72 AND CYS-106;TISSUE SPECIFICITY
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN AAV INHIBITION;SUBCELLULAR LOCATION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CATALYTIC ACTIVITY;INDUCTION;ALTERNATIVE SPLICING (ISOFORMS 1 AND 2)
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN FOREIGN DNA CLEARANCE;CATALYTIC ACTIVITY;TISSUE SPECIFICITY;INDUCTION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN DNA DEMETHYLATION
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
17.
"Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities."
Bulliard Y.
,
Narvaiza I.
,
Bertero A.
,
Peddi S.
,
Roehrig U.F.
,
Ortiz M.
,
Zoete V.
,
Castro-Diaz N.
,
Turelli P.
,
Telenti A.
,
Michielin O.
,
Weitzman M.D.
,
Trono D.
J. Virol.85:1765-1776(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN HOST DEFENSE;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;MUTAGENESIS OF ARG-28; HIS-29; LYS-30; ASN-57; LYS-60; ARG-69; GLU-72; TRP-98; ARG-128; TYR-130; ASP-131; ASP-133 AND TYR-136
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
19.
"Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism."
Suspene R.
,
Aynaud M.M.
,
Guetard D.
,
Henry M.
,
Eckhoff G.
,
Marchio A.
,
Pineau P.
,
Dejean A.
,
Vartanian J.P.
,
Wain-Hobson S.
Proc. Natl. Acad. Sci. U.S.A.108:4858-4863(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
22.
"Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A."
Carpenter M.A.
,
Li M.
,
Rathore A.
,
Lackey L.
,
Law E.K.
,
Land A.M.
,
Leonard B.
,
Shandilya S.M.
,
Bohn M.F.
,
Schiffer C.A.
,
Brown W.L.
,
Harris R.S.
J. Biol. Chem.287:34801-34808(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TRIB3;SUBCELLULAR LOCATION
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN HTLV-1 RESTRICTION
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH AGO2
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW