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Index > Protein center > APOBEC3A(Gene name) > Human
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  • APOBEC3A (Gene name),
  • Probable DNA dC->dU-editing enzyme APOBEC-3A (Protein name ),  ABC3A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    APOBEC3A;
    Protein name:
    Probable DNA dC->dU-editing enzyme APOBEC-3A(A3A);
    Alternative:
    Phorbolin-1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Single-stranded DNA cytidine deaminase involved in foreign DNA clearance. May trigger C-to-U hypermutation in exogenous DNA leading to its degradation. Provides cellular innate resistance to a specific panel of genetic invaders including endogenous retroelements and a subset of viruses. May have a preference for cytidines in a C-C sequence context. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
    Subcellular Location:
    Nucleus Cytoplasm
    Protein Attributes:
    Sequence length:
    199
    Sequence:
    50:
    MEASPASGPR | HLMDPHIFTS | NFNNGIGRHK | TYLCYEVERL | DNGTSVKMDQ | 
    100:
    HRGFLHNQAK | NLLCGFYGRH | AELRFLDLVP | SLQLDPAQIY | RVTWFISWSP | 
    150:
    CFSWGCAGEV | RAFLQENTHV | RLRIFAARIY | DYDPLYKEAL | QMLRDAGAQV | 
    199:
    SIMTYDEFKH | CWDTFVDHQG | CPFQPWDGLD | EHSQALSGRL | RAILQNQGN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human A3A
    CLIA Kit for Human A3A
    Polyclonal Antibody for Human A3A
    Monoclonal Antibody for Human A3A
    Protein for Human A3A

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1."
      Madsen P.P. , Anant S. , Rasmussen H.H. , Gromov P. , Vorum H. , Dumanski J.P. , Tommerup N. , Collins J.E. , Wright C.L. , Dunham I. , Macginnitie A.J. , Davidson N.O. , Celis J.E.
      J. Invest. Dermatol.113:162-169(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 19-27; 31-35; 53-60; 112-123; 129-137 AND 192-198;FUNCTION
      tissue: Keratinocyte.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    5. 5.
      "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
      Rasmussen H.H. , van Damme J. , Puype M. , Gesser B. , Celis J.E. , Vandekerckhove J.
      Electrophoresis13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 53-60; 112-121 AND 129-137
      tissue: Keratinocyte.
    6. 6.
      "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22."
      Jarmuz A. , Chester A. , Bayliss J. , Gisbourne J. , Dunham I. , Scott J. , Navaratnam N.
      Genomics79:285-296(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GENE FAMILY ORGANIZATION;TISSUE SPECIFICITY
    7. 7.
      "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business."
      Wedekind J.E. , Dance G.S.C. , Sowden M.P. , Smith H.C.
      Trends Genet.19:207-216(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON APOBEC FAMILIES
    8. 8.
      "Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif."
      Mariani R. , Chen D. , Schroefelbauer B. , Navarro F. , Koenig R. , Bollman B. , Muenk C. , Nymark-McMahon H. , Landau N.R.
      Cell114:21-31(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HOST DEFENSE
    9. 9.
      "APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons."
      Chen H. , Lilley C.E. , Yu Q. , Lee D.V. , Chou J. , Narvaiza I. , Landau N.R. , Weitzman M.D.
      Curr. Biol.16:480-485(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HOST DEFENSE;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;MUTAGENESIS OF HIS-70; GLU-72 AND CYS-106;TISSUE SPECIFICITY
    10. 10.
      "The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements."
      Chiu Y.L. , Greene W.C.
      Annu. Rev. Immunol.26:317-353(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    11. 11.
      "Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase."
      Narvaiza I. , Linfesty D.C. , Greener B.N. , Hakata Y. , Pintel D.J. , Logue E. , Landau N.R. , Weitzman M.D.
      PLoS Pathog.5:E1000439-E1000439(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN AAV INHIBITION;SUBCELLULAR LOCATION
    12. 12.
      "Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms."
      Thielen B.K. , McNevin J.P. , McElrath M.J. , Hunt B.V. , Klein K.C. , Lingappa J.R.
      J. Biol. Chem.285:27753-27766(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;INDUCTION;ALTERNATIVE SPLICING (ISOFORMS 1 AND 2)
    13. 13.
      "APOBEC3 proteins mediate the clearance of foreign DNA from human cells."
      Stenglein M.D. , Burns M.B. , Li M. , Lengyel J. , Harris R.S.
      Nat. Struct. Mol. Biol.17:222-229(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN FOREIGN DNA CLEARANCE;CATALYTIC ACTIVITY;TISSUE SPECIFICITY;INDUCTION
    14. 14.
      "Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction."
      Refsland E.W. , Stenglein M.D. , Shindo K. , Albin J.S. , Brown W.L. , Harris R.S.
      Nucleic Acids Res.38:4274-4284(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    15. 15.
      "Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain."
      Guo J.U. , Su Y. , Zhong C. , Ming G.L. , Song H.
      Cell145:423-434(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN DNA DEMETHYLATION
    16. 16.
      "APOBEC3A can activate the DNA damage response and cause cell-cycle arrest."
      Landry S. , Narvaiza I. , Linfesty D.C. , Weitzman M.D.
      EMBO Rep.12:444-450(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 17.
      "Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities."
      Bulliard Y. , Narvaiza I. , Bertero A. , Peddi S. , Roehrig U.F. , Ortiz M. , Zoete V. , Castro-Diaz N. , Turelli P. , Telenti A. , Michielin O. , Weitzman M.D. , Trono D.
      J. Virol.85:1765-1776(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HOST DEFENSE;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;MUTAGENESIS OF ARG-28; HIS-29; LYS-30; ASN-57; LYS-60; ARG-69; GLU-72; TRP-98; ARG-128; TYR-130; ASP-131; ASP-133 AND TYR-136
    18. 18.
      "Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."
      Hultquist J.F. , Lengyel J.A. , Refsland E.W. , LaRue R.S. , Lackey L. , Brown W.L. , Harris R.S.
      J. Virol.85:11220-11234(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    19. 19.
      "Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism."
      Suspene R. , Aynaud M.M. , Guetard D. , Henry M. , Eckhoff G. , Marchio A. , Pineau P. , Dejean A. , Vartanian J.P. , Wain-Hobson S.
      Proc. Natl. Acad. Sci. U.S.A.108:4858-4863(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    20. 20.
      "Cytosine deaminases APOBEC3A, APOBEC3C, and APOBEC3H: Current understanding of their functional roles."
      Love R.
      Student Perspec. Contemp. Virol.0:0-0(2011)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    21. 21.
      "Retroelements versus APOBEC3 family members: No great escape from the magnificent seven."
      Arias J.F. , Koyama T. , Kinomoto M. , Tokunaga K.
      Front. Microbiol.3:275-275(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    22. 22.
      "Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A."
      Carpenter M.A. , Li M. , Rathore A. , Lackey L. , Law E.K. , Land A.M. , Leonard B. , Shandilya S.M. , Bohn M.F. , Schiffer C.A. , Brown W.L. , Harris R.S.
      J. Biol. Chem.287:34801-34808(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    23. 23.
      "Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A."
      Aynaud M.M. , Suspene R. , Vidalain P.O. , Mussil B. , Guetard D. , Tangy F. , Wain-Hobson S. , Vartanian J.P.
      J. Biol. Chem.287:39182-39192(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRIB3;SUBCELLULAR LOCATION
    24. 24.
      "APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1."
      Ooms M. , Krikoni A. , Kress A.K. , Simon V. , Muenk C.
      J. Virol.86:6097-6108(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HTLV-1 RESTRICTION
    25. 25.
      "HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."
      Phalora P.K. , Sherer N.M. , Wolinsky S.M. , Swanson C.M. , Malim M.H.
      J. Virol.86:11712-11724(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AGO2
    26. 26.
      "Functions and regulation of the APOBEC family of proteins."
      Smith H.C. , Bennett R.P. , Kizilyer A. , McDougall W.M. , Prohaska K.M.
      Semin. Cell Dev. Biol.23:258-268(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
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