Protein name:
DNA dC->dU-editing enzyme APOBEC-3F;
Alternative:
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F(A3F);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Forms heterodimers with APOBEC3G. Binds HIV-1 Vif. In the absence of Vif protein, specifically packaged into HIV-1 virions.
Function:
Host cellular restriction factor that may have antiviral activities against exogenous and endogenous viruses, as well as retrotransposons. After being packaged into HIV-1 virions, blocks productive infection by massively editing dC residues to dU on the DNA minus strand during reverse transcription. The editing of the minus strand DNA of HIV-1 during reverse transcription leads to G-to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MKPHFRNTVE | RMYRDTFSYN | FYNRPILSRR | NTVWLCYEVK | TKGPSRPRLD |
100:
AKIFRGQVYS | QPEHHAEMCF | LSWFCGNQLP | AYKCFQITWF | VSWTPCPDCV |
150:
AKLAEFLAEH | PNVTLTISAA | RLYYYWERDY | RRALCRLSQA | GARVKIMDDE |
200:
EFAYCWENFV | YSEGQPFMPW | YKFDDNYAFL | HRTLKEILRN | PMEAMYPHIF |
250:
YFHFKNLRKA | YGRNESWLCF | TMEVVKHHSP | VSWKRGVFRN | QVDPETHCHA |
300:
ERCFLSWFCD | DILSPNTNYE | VTWYTSWSPC | PECAGEVAEF | LARHSNVNLT |
350:
IFTARLYYFW | DTDYQEGLRS | LSQEGASVEI | MGYKDFKYCW | ENFVYNDDEP |
373:
FKPWKGLKYN | FLFLDSKLQE | ILE
Vaild Sequence:
Related Databases
Uniprot:
