ABCA7 ELISA Kit for Human(Homo sapiens) | EIAab.comABCA7 ELISA Kit for Human(Homo sapiens)

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ABCA7 (Gene name),

ATP-binding cassette sub-family A member 7 (Protein name ), ABCA7_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ABCA7;

Protein name:

ATP-binding cassette sub-family A member 7;

Alternative:

Autoantigen SS-N;ABCA-SSN;Macrophage ABC transporter;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.

Subcellular Location:

Cell membrane Multi-pass membrane protein Golgi apparatus membrane Multi-pass membrane protein Endosome membrane Multi-pass membrane protein Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney. Isoform 2 may localize to the endoplasmic reticulum.

Protein Attributes:

Sequence length:

2146

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2146:

SKDQGKDEDT | EEQKEAGVGV | DPAPGLQHPK | RVSQFLDDPS | TAETVL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q8IZY2

KEGG:

hsa:10347

UniGene:

Hs.134514

STRING:

9606.ENSP00000263094

Pfam:

PF00005

SMR:

Q8IZY2

MIM:

605414

Uniprot:

Q8IZY2

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ELISA Kit for Human ATP-binding cassette sub-family A member 7

Cat.:

E15004h

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96T

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ELISA Kit for Human ATP-binding cassette sub-family A member 7

Cat.:

E15004m

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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ELISA Kit for Human ATP-binding cassette sub-family A member 7

MSDS:

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CLIA Kit for Human ATP-binding cassette sub-family A member 7

MSDS:

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CLIA Kit for Human ATP-binding cassette sub-family A member 7

Cat.:

U15004h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human ATP-binding cassette sub-family A member 7

Cat.:

U15004m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human ATP-binding cassette sub-family A member 7

Monoclonal Antibody for Human ATP-binding cassette sub-family A member 7

Protein for Human ATP-binding cassette sub-family A member 7

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7)."
Kaminski W.E. , Orso E. , Diederich W. , Klucken J. , Drobnik W. , Schmitz G.
Biochem. Biophys. Res. Commun.273:532-538(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS GLN-1349; ALA-1527 AND SER-2045;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INDUCTION
tissue: Macrophage.
2.

"Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene."
Kaminski W.E. , Piehler A. , Schmitz G.
Biochem. Biophys. Res. Commun.278:782-789(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ALA-1527
3.

"Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjogren's Syndrome."
Tanaka A.R. , Ikeda Y. , Abe-Dohmae S. , Arakawa R. , Sadanami K. , Kidera A. , Nakagawa S. , Nagase T. , Aoki R. , Kioka N. , Amachi T. , Yokoyama S. , Ueda K.
Biochem. Biophys. Res. Commun.283:1019-1025(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANTS GLN-1349; ALA-1527 AND SER-2045
tissue: Thymus.
4.

"Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter."
Broccardo C. , Osorio J. , Luciani M.-F. , Schriml L.M. , Prades C. , Shulenin S. , Arnould I. , Naudin L. , Lafargue C. , Rosier M. , Jordan B. , Mattei M.-G. , Dean M. , Denefle P. , Chimini G.
Cytogenet. Cell Genet.92:264-270(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS GLY-188; ALA-1527 AND SER-2045;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
tissue: Spleen.
5.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"Isolation of autoantigen cDNAs by lambda phage surface display."
Niwa M. , Maruyama M. , Fujimoto T. , Dohi K. , Maruyama I.N.
Submitted (1999-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 195-352 (ISOFORMS 1/2)
tissue: Cervix carcinoma.
7.

"Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release."
Ikeda Y. , Abe-Dohmae S. , Munehira Y. , Aoki R. , Kawamoto S. , Furuya A. , Shitara K. , Amachi T. , Kioka N. , Matsuo M. , Yokoyama S. , Ueda K.
Biochem. Biophys. Res. Commun.311:313-318(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
8.

"ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux."
Wang N. , Lan D. , Gerbod-Giannone M. , Linsel-Nitschke P. , Jehle A.W. , Chen W. , Martinez L.O. , Tall A.R.
J. Biol. Chem.278:42906-42912(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
9.

"Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization."
Kielar D. , Kaminski W.E. , Liebisch G. , Piehler A. , Wenzel J.J. , Moehle C. , Heimerl S. , Langmann T. , Friedrich S.O. , Boettcher A. , Barlage S. , Drobnik W. , Schmitz G.
J. Invest. Dermatol.121:465-474(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
10.

"Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein."
Abe-Dohmae S. , Ikeda Y. , Matsuo M. , Hayashi M. , Okuhira K. , Ueda K. , Yokoyama S.
J. Biol. Chem.279:604-611(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
11.

"Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8."
Iida A. , Saito S. , Sekine A. , Mishima C. , Kitamura Y. , Kondo K. , Harigae S. , Osawa S. , Nakamura Y.
J. Hum. Genet.47:285-310(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLY-188; ALA-319; ARG-395; HIS-463; THR-718; GLN-1349; ARG-1686 AND SER-2045

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