ABCG8 ELISA Kit for Human(Homo sapiens) | EIAab.comABCG8 ELISA Kit for Human(Homo sapiens)

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ABCG8 (Gene name),

ATP-binding cassette sub-family G member 8 (Protein name ), ABCG8_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ABCG8;

Protein name:

ATP-binding cassette sub-family G member 8;

Alternative:

Sterolin-2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

May form heterodimers with ABCG5 or be tightly coupled to ABCG5 along a pathway regulating diatery-sterol absorption and excretion.

Function:

Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

673

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

673:

SGGFMVLYYV | SLRFIKQKPS | QDW

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF01061

KEGG:

hsa:64241

MIM:

210250

STRING:

9606.ENSP00000272286

UniGene:

Hs.413931

SMR:

Q9H221

String:

Q9H221

Uniprot:

Q9H221

FOR

ELISA Kit for Human ATP-binding cassette sub-family G member 8

CLIA Kit for Human ATP-binding cassette sub-family G member 8

Polyclonal Antibody for Human ATP-binding cassette sub-family G member 8

Monoclonal Antibody for Human ATP-binding cassette sub-family G member 8

Protein for Human ATP-binding cassette sub-family G member 8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters."
Berge K.E. , Tian H. , Graf G.A. , Yu L. , Grishin N.V. , Schultz J. , Kwiterovich P. , Shan B. , Barnes R. , Hobbs H.H.
Science290:1771-1775(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS STSL THR-231; GLN-263; ARG-574 AND ARG-596;VARIANT CYS-54
2.

"Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively."
Lu K. , Lee M.-H. , Hazard S. , Brooks-Wilson A. , Hidaka H. , Kojima H. , Ose L. , Stalenhoef A.F.H. , Mietinnen T. , Bjorkhem I. , Bruckert E. , Pandya A. , Brewer H.B. Jr. , Salen G. , Dean M. , Srivastava A.K. , Patel S.B.
Am. J. Hum. Genet.69:278-290(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2);VARIANTS STSL HIS-184; THR-231; GLN-263; HIS-405; PRO-501; SER-543; PHE-570 DEL; PRO-572; ARG-574; GLU-574 AND ARG-596;VARIANTS HIS-19; CYS-54; LYS-238; VAL-259; LYS-400; ARG-575 AND ALA-632
tissue: Liver.
3.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"Role of ABCG1 and other ABCG family members in lipid metabolism."
Schmitz G. , Langmann T. , Heimerl S.
J. Lipid Res.42:1513-1520(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
5.

"Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia."
Hubacek J.A. , Berge K.E. , Cohen J.C. , Hobbs H.H.
Hum. Mutat.18:359-360(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-19; CYS-54; LYS-400; ALA-632 AND PHE-641
6.

"Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8."
Iida A. , Saito S. , Sekine A. , Mishima C. , Kitamura Y. , Kondo K. , Harigae S. , Osawa S. , Nakamura Y.
J. Hum. Genet.47:285-310(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-54 AND LYS-400
7.

"A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease."
Buch S. , Schafmayer C. , Voelzke H. , Becker C. , Franke A. , von Eller-Eberstein H. , Kluck C. , Baessmann I. , Brosch M. , Lammert F. , Miquel J.F. , Nervi F. , Wittig M. , Rosskopf D. , Timm B. , Hoell C. , Seeger M. , ElSharawy A. , more...
Nat. Genet.39:995-999(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-19;ASSOCIATION WITH GBD4

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