Abi1 ELISA Kit for Mouse(Mus musculus) | EIAab.comAbi1 ELISA Kit for Mouse(Mus musculus) | EIAab.com

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Abi1 (Gene name),

Abl interactor 1 (Protein name ), ABI1_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

Abi1(Ssh3bp1);

Protein name:

Abl interactor 1;

Alternative:

Ablphilin-1;Abelson interactor 1(Abi-1);Spectrin SH3 domain-binding protein 1;Eps8 SH3 domain-binding protein(Eps8-binding protein);e3B1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with ENAH, Abelson murine leukemia virus V-ABL, ABL1, STX1A, SNAP25, VAMP2, and through its N-terminus with WASF1. Part of a complex consisting of ABI1, STX1A and SNAP25. Part of a complex consisting of ABI1, EPS8 and SOS1. Interacts with EPS8, SOS1, SOS2, GRB2, SPTA1, and the first SH3 domain of NCK1 (By similarity). Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2.

Function:

May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH (By similarity). Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level.

Subcellular Location:

Cytoplasm Nucleus Cell projection lamellipodium Cell projection filopodium Cell projection growth cone Cell junction synapse synaptosome Cytoplasm cytoskeleton Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes.

Protein Attributes:

Sequence length:

481

Sequence:

50:

MAELQMLLEE | EIPSGKRALI | ESYQNLTRVA | DYCENNYIQA | TDKRKALEET |

100:

KAYTTQSLAS | VAYQINALAN | NVLQLLDIQA | SQLRRMESSI | NHISQTVDIH |

150:

KEKVARREIG | ILTTNKNTSR | THKIIAPANM | ERPVRYIRKP | IDYTVLDDVG |

200:

HGVKWLKAKH | GNNQPARTGT | LSRTNPPTQK | PPSPPVSGRG | TLGRNTPYKT |

250:

LEPVKPPTVP | NDYMTSPARL | GSQHSPGRTA | SLNQRPRTHS | GSSGGSGSRE |

300:

NSGSSSIGIP | IAVPTPSPPT | AGPAAPGAAP | GSQYGTMTRQ | ISRHNSTTSS |

350:

TSSGGYRRTP | SVAAQFSAQP | HVNGGPLYSQ | NSISVAPPPP | PMPQLTPQIP |

400:

LTGFVARVQE | NIADSPTPPP | PPPPDDIPMF | DDSPPPPPPP | PVDYEDEEAA |

450:

VVQYSDPYAD | GDPAWAPKNY | IEKVVAIYDY | TKDKDDELSF | KEGAIIYVIK |

481:

KNDDGWFEGV | CNRVTGLFPG | NYVESIMHYT | D

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

KEGG:

Pfam:

SMR:

String:

Uniprot:

FOR

ELISA Kit for Mouse Abl interactor 1

ELISA Kit for Mouse Abl interactor 1

ELISA Kit for Mouse Abl interactor 1

CLIA Kit for Mouse Abl interactor 1

CLIA Kit for Mouse Abl interactor 1

CLIA Kit for Mouse Abl interactor 1

Polyclonal Antibody for Mouse Abl interactor 1

Polyclonal Antibody for Mouse Abl interactor 1

Polyclonal Antibody for Mouse Abl interactor 1

Monoclonal Antibody for Mouse Abl interactor 1

Monoclonal Antibody for Mouse Abl interactor 1

Monoclonal Antibody for Mouse Abl interactor 1

Protein for Mouse Abl interactor 1

Protein for Mouse Abl interactor 1

Protein for Mouse Abl interactor 1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Inhibition of v-Abl transformation in 3T3 cells overexpressing different forms of the Abelson interactor protein Abi-1."
Ikeguchi A. , Yang H.-Y. , Gao G. , Goff S.P.
Oncogene20:4926-4934(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);ALTERNATIVE SPLICING (ISOFORM 2);FUNCTION
strain: BALB/c.
2.

"t(10;11)-acute leukemias with MLL-AF10 and MLL-ABI1 chimeric transcripts: specific expression patterns of ABI1 gene in leukemia and solid tumor cell lines."
Shibuya N. , Taki T. , Mugishima H. , Chin M. , Tsuchida M. , Sako M. , Kawa K. , Ishii E. , Miura I. , Yanagisawa M. , Hayashi Y.
Genes Chromosomes Cancer32:1-10(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5)
strain: C57BL/6J.
tissue: Bone marrow.
tissue: Diencephalon.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
5.

"Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity."
Shi Y. , Alin K. , Goff S.P.
Genes Dev.9:2583-2597(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 70-360 (ISOFORM 4);FUNCTION;PHOSPHORYLATION;TISSUE SPECIFICITY;INTERACTION WITH ABL1 AND V-ABL
6.

"EPS8 and E3B1 transduce signals from Ras to Rac."
Scita G. , Nordstrom J. , Carbone R. , Tenca P. , Giardina G. , Gutkind S. , Bjarnegard M. , Betsholtz C. , Di Fiore P.P.
Nature401:290-293(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN A COMPLEX WITH EPS8 AND SOS1
7.

"Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase."
Tani K. , Sato S. , Sukezane T. , Kojima H. , Hirose H. , Hanafusa H. , Shishido T.
J. Biol. Chem.278:21685-21692(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ENAH
8.

"Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels."
Echarri A. , Lai M.J. , Robinson M.R. , Pendergast A.M.
Mol. Cell. Biol.24:4979-4993(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH STX1A; SNAP25; VAMP2 AND WASF1
9.

"Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system."
Courtney K.D. , Grove M. , Vandongen H. , Vandongen A. , LaMantia A.-S. , Pendergast A.M.
Mol. Cell. Neurosci.16:244-257(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
10.

"The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia."
Stradal T.E.B. , Courtney K.D. , Rottner K. , Hahne P. , Small J.V. , Pendergast A.M.
Curr. Biol.11:891-895(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
11.

"Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation."
Steffen A. , Rottner K. , Ehinger J. , Innocenti M. , Scita G. , Wehland J. , Stradal T.E.B.
EMBO J.23:749-759(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COMPONENT OF WAVE2 COMPLEX
strain: C57BL/6.
tissue: Brain.
12.

"Eps8 controls actin-based motility by capping the barbed ends of actin filaments."
Disanza A. , Carlier M.F. , Stradal T.E. , Didry D. , Frittoli E. , Confalonieri S. , Croce A. , Wehland J. , Di Fiore P.P. , Scita G.
Nat. Cell Biol.6:1180-1188(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EPS8
13.

"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-428;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
14.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183 AND TYR-213;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.

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